ESRC IAA Workshop: Towards Maximising International PhD Students' Experience: Extended Summary

No abstract available

The surprising dual action of glucocorticoids = A glükokortikoidok meglepő kettős hatása

A glükokortikoid hormonok kettős hatást fejtenek ki a gyomorra: élettani gyomorvédő és kóros proulcerogén hatást. Élettani körülmények között, még akut stressz - helyzetben is, a glükokortikoidok adaptív hatást, ezáltal védelmet fejtenek ki a gyomorra. A most áttekintett eredmények azt mutatják, hogy az akut stressz során felszabaduló glükokortikoidok természetesen előforduló védőfaktorok, amelyek fontos szerepet játszanak a gyomornyálkahártya integritásának a fenntartásában

Enhancing the Experience of International Doctoral Researchers - Key Messages

No abstract available

How Does Fasting Affect Cognition? An Updated Systematic Review (2013–2020)

Purpose of Review: The goal of this review was to provide an update on the literature examining how voluntary, temporary abstention from eating impacts cognitive function. / Recent Findings: We evaluated peer-reviewed articles published between August 2013 and January 2021 that assessed adults, included a measure of cognitive functioning with neutral stimuli, and compared individuals in a fasted state to individuals in a fed state (either within- or between-subject designs). Nineteen articles (21 studies) met inclusion criteria. Sample sizes, fasting methods, and tasks varied across studies. Review of studies indicated that fasting was associated with deficits in cognitive functioning; few studies indicated a benefit in cognitive functioning following a single voluntary fast. / Summary: The heterogeneity and rarity of available studies limits the conclusions that can be drawn. Several crucial psychosocial and sociodemographic moderators remain unexplored. Recommendations for future work are discussed

Quantum dot-based multiphoton fluorescent pipettes for targeted neuronal electrophysiology

Targeting visually identified neurons for electrophysiological recording is a fundamental neuroscience technique; however, its potential is hampered by poor visualization of pipette tips in deep brain tissue. We describe quantum dot-coated glass pipettes that provide strong two-photon contrast at deeper penetration depths than those achievable with current methods. We demonstrated the pipettes' utility in targeted patch-clamp recording experiments and single-cell electroporation of identified rat and mouse neurons in vitro and in vivo

Detection of virulence factors in α-haemolytic Escherichia coli strains isolated from various clinical materials

ABSTRACTIn total, 201 α-haemolytic Escherichia coli isolates from various clinical materials (urine samples and vaginal and rectal swabs) were examined by PCR for the presence of genes for the virulence factors α-haemolysin (hly), cytotoxic necrotising factor type 1 (cnf1), P-fimbriae (pap), S/F1C-fimbriae (sfa/foc), aerobactin (aer) and afimbrial adhesin (afaI). Among vaginal isolates, 96% were positive for cnf1, compared with 80% of urine strains (p 0.02) and 63% of rectal strains (p 0.0001). Similarly, sfa/foc-specific DNA sequences were found in 97% of vaginal isolates compared with 75% of rectal strains (p 0.004). The afa1 and aer genes were associated more with rectal a-haemolytic E. coli strains than with extra-intestinal isolates. The results suggested that CNF1 and/or S/F1C-fimbriae contribute to colonisation and persistence of a-haemolytic E. coli strains in the vaginal environment

Surge recovery techniques for the Tevatron cold compressors

The Fermilab Tevatron cryogenic system utilizes high-speed centrifugal cold compressors, made by Ishikawajima-Harima Heavy Industries Co. Ltd. (IHI), for high-energy operations [1]. The compressor is designed to pump 60 g/s of 3.6 K saturated helium vapor at a pressure ratio of 2.8, with an off-design range of 40 to 70 g/s and operating speeds between 40 and 95 krpm. Since initial commissioning in 1993, Tevatron transient conditions such as quench recovery have led to multiple-location machine trips as a result of the cold compressors entering the surge regime. Historically, compressors operating at lower inlet pressures and higher speeds have been especially susceptible to these machine trips and it was not uncommon to have multiple compressor trips during large multiple-house quenches. In order to cope with these events and limit accelerator down time, surge recovery techniques have been implemented in an attempt to prevent the compressors from tripping once the machine entered this surge regime. This paper discusses the different methods of surge recovery that have been employed. Data from tests performed at the Cryogenic Test Facility at Fermilab as well as actual Tevatron operational data were utilized. In order to aid in the determination of the surge region, a full mapping study was undertaken to characterize the entire pressure field of the cold compressor. These techniques were then implemented and tested at several locations in the Tevatron with some success

A conceptual enquiry into communities of practice as praxis in international doctoral education

Undertaking a PhD entails diverse and multi-faceted challenges as doctoral researchers enter a distinct academic culture that requires transition to a new level and threshold of learning – with both knowledge acquisition and production at the core. While doctoral researchers are expected to secure different dimensions of knowledge, which necessitates meaningful ‘dialogue’ with experts, the colossal task is still ironically associated with isolated doctoral experience and somewhat limited postgraduate supervision provision. With the extra concerns typically confronting the international doctoral cohort, the pressure tends be intensified, and may lead to psychological well-being concerns. Nevertheless, there is evidence from the literature that highlights the often unacknowledged forms of learning opportunities and support mechanisms via community participation. By employing communities of practice as the main framework, this conceptual paper exemplifies the crucial role played by these communities – how these communities serve to scaffold doctoral researchers’ academic progress, support their psychological adjustments, and reinforce the crucial, but perhaps limited, formal doctoral support provision. By featuring effective examples of educational praxis via these communities, our paper offers a holistic understanding of formal and informal infrastructures as part of the wider doctoral ecology with a view to achieving a more holistic and meaningful doctoral experience

A conceptual enquiry into communities of practice as praxis in international doctoral education

Undertaking a PhD entails diverse and multi-faceted challenges as doctoral researchers enter a distinct academic culture that requires transition to a new level and threshold of learning – with both knowledge acquisition and production at the core. While doctoral researchers are expected to secure different dimensions of knowledge, which necessitates meaningful ‘dialogue’ with experts, the colossal task is still ironically associated with isolated doctoral experience and somewhat limited postgraduate supervision provision. With the extra concerns typically confronting the international doctoral cohort, the pressure tends be intensified, and may lead to psychological well-being concerns. Nevertheless, there is evidence from the literature that highlights the often unacknowledged forms of learning opportunities and support mechanisms via community participation. By employing communities of practice as the main framework, this conceptual paper exemplifies the crucial role played by these communities – how these communities serve to scaffold doctoral researchers’ academic progress, support their psychological adjustments, and reinforce the crucial, but perhaps limited, formal doctoral support provision. By featuring effective examples of educational praxis via these communities, our paper offers a holistic understanding of formal and informal infrastructures as part of the wider doctoral ecology with a view to achieving a more holistic and meaningful doctoral experience

Installation, commissioning, and testing of the HB650 CM at PIP2IT

The Proton Improvement Plan-II (PIP-II) is a major upgrade to the Fermilab accelerator complex, featuring a new 800-MeV Superconducting Radio-Frequency (SRF) linear accelerator (LINAC) powering the accelerator complex to provide the world's most intense high-energy neutrino beam. This paper describes the conversion of the PIP-II Injector Test Facility (PIP2IT) cryogenic system into a test stand for PIP-II High-Beta 650 MHz (HB650) cryomodules at Fermilab's Cryomodule Test Facility (CMTF). A description of the associated mechanical, electrical, and controls modifications necessary for testing HB650 cryomodules are provided. The cooldown and warmup requirements, procedures and associated controls logic is described.Comment: 2023 Cryogenic Engineering Conference and International Cryogenic Materials Conference (CEC/ICMC