9 research outputs found
Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression.
- Publication venue
- Cell Commun Signal
- Publication date
- 12/02/2022
- Field of study
AIM: The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought to determine the optimal in vitro chondrocyte co-culture condition that promotes infrapatellar fat pad-derived (IFPD) ASC chondrogenic gene expression in a novel co-culture combination. METHODS: In our study, we utilized an in vitro autologous co-culture of IFPD ASCs and articular chondrocytes derived from Kellgren-Lawrence Grade III/IV osteoarthritic human knee joints at ASC-to-chondrocyte seeding log ratios of 1:1, 10:1, and 100:1. Gene expression following in vitro co-culture was quantified by RT-qPCR with a panel comprising COL1A1, COL2A1, COL10A1, L-SOX5, SOX6, SOX9, ACAN, HSPG2, and COMP for chondrogenic gene expression. RESULTS: The chondrogenic gene expression profiles from co-cultures were greater than would be expected from an expression profile modeled from chondrocyte and ASC-only monocultures. Additionally, chondrogenic gene expression decreased with increasing ASC-to-chondrocyte seeding ratios. CONCLUSIONS: These findings provide insight into the mechanisms underlying clinical ASC therapies and signifies that IFPD ASCs pre-conditioned by chondrocyte co-culture may have improved chondrogenic potential for cartilage repair. This model can help further understand IFPD ASCs in chondral and osteochondral repair and the chondrogenic pathways involved. Video Abstract
Sexual Health and Well-being Among Older Men and Women in England: Findings from the English Longitudinal Study of Ageing
- Author
- A Karraker
- A Nicolosi
- A Steptoe
- AG Tristano
- CG Bacon
- CH Mercer
- Daryl B. O’Connor
- David M. Lee
- DE Steffick
- EA Impett
- FS Christopher
- IM Thompson
- J Bancroft
- J DeLamater
- J Hill
- James Nazroo
- JB McKinlay
- JE Morley
- JJ Sanchez-Cruz
- KA Fenton
- KR Mitchell
- L Tiefer
- LJ Waite
- Margaret Blake
- MH Blanker
- Neil Pendleton
- R Mak
- R Suzman
- RF Baumeister
- ST Lindau
- ST Lindau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
We describe levels of sexual activity, problems with sexual functioning, and concerns about sexual health among older adults in the English Longitudinal Study of Ageing (ELSA), and associations with age, health, and partnership factors. Specifically, a total of 6,201 core ELSA participants (56 % women) aged 50 to >90 completed a comprehensive Sexual Relationships and Activities questionnaire (SRA-Q) included in ELSA Wave 6 (2012/13). The prevalence of reporting any sexual activity in the last year declined with age, with women less likely than men at all ages to report being sexually active. Poorer health was associated with lower levels of sexual activity and a higher prevalence of problems with sexual functioning, particularly among men. Difficulties most frequently reported by sexually active women related to becoming sexually aroused (32 %) and achieving orgasm (27 %), while for men it was erectile function (39 %). Sexual health concerns most commonly reported by women related to their level of sexual desire (11 %) and frequency of sexual activities (8 %). Among men it was level of sexual desire (15 %) and erectile difficulties (14 %). While the likelihood of reporting sexual health concerns tended to decrease with age in women, the opposite was seen in men. Poor sexual functioning and disagreements with a partner about initiating and/or feeling obligated to have sex were associated with greater concerns about and dissatisfaction with overall sex life. Levels of sexual activity decline with increasing age, although a sizable minority of men and women remain sexually active until the eighth and ninth decades of life. Problems with sexual functioning were relatively common, but overall levels of sexual health concerns were much lower. Sexually active men reported higher levels of concern with their sexual health and sexual dissatisfaction than women at all ages. Older peoples’ sexual health should be managed, not just in the context of their age, gender, and general health, but also within their existing sexual relationship
Controversies in the Management of Vesicoureteral Reflux
- Author
- A Akhavan
- A Atala
- A Hoberman
- AJ Al-Sayyad
- AJ Kirsch
- AM Arlen
- AM Arlen
- Angela M. Arlen
- B O’Donnell
- C Peters
- CA Peters
- CA Peters
- CH Cheng
- Christopher S. Cooper
- CP Nelson
- CP Nelson
- CS Cooper
- CS Cooper
- CW Schwab
- DM Wheeler
- G Janetschek
- G Lackgren
- G Roussey-Kesler
- GM Grimsby
- GS Marchini
- HT Nguyen
- HT Nguyen
- I Stanasel
- J Sung
- J Wan
- JC Craig
- JC Routh
- JD Kaye
- JF Kalisvaart
- JS Elder
- JS Elder
- KB Roberts
- KY Lin
- M Koyle
- MA Sargent
- MJ Knudson
- MJ Knudson
- MS Gundeti
- N Shaikh
- P Brandstrom
- P Casale
- PP Dangle
- RH Mak
- RM Ehrlich
- RP Smith
- S Sjostrom
- SA Saadeh
- SE Alexander
- SJ Skoog
- TM Juliano
- TS Lendvay
- U Jodal
- ZM McMillian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Amnestic mild cognitive impairment in Parkinson’s disease: White matter structural changes and mechanisms
- Author
- A Cherubini
- A Garg
- A Hanganu
- AA Kehagia
- AJ Hughes
- AL Alexander
- AM Winkler
- American Psychiatric Association
- B Deng
- BH Zhang
- C Metzler-Baddeley
- C Randolph
- C. Beaulieu
- CG Goetz
- CG Koay
- CH Lin
- CP Weingarten
- D Aarsland
- DJ Madden
- E Kalbe
- E Mak
- F Agosta
- F Nieuwhof
- Fuyong Chen
- GE Alexander
- GM Halliday
- H Braak
- H Zhang
- Haobo Zhang
- HC Kraemer
- HJ Kim
- I Litvan
- J Prodoehl
- JE Lee
- JJ Tanner
- K Kantarci
- Kai Wang
- L Christopher
- MF Folstein
- MM Hoehn
- NI Bohnen
- NW Sterling
- O Lucas-Jimenez
- PJ Basser
- PJ Planetta
- Qing Guan
- RA Barker
- SL Collinson
- SM Smith
- SM Smith
- T Hattori
- T Nichols
- Tao Wu
- TL Pitcher
- TR Melzer
- V Douet
- W van Hecke
- Wei Tao
- Xianghong Meng
- Y Compta
- Yuejia Luo
- Z Zheng
- Zhihao Li
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation
- Author
- Adams
- Adey
- Adey
- Ahmed
- Alberts
- Antonsson
- Ashton
- Barnothy
- Becker
- Benjamin S. Harrison
- Bianco
- Bianco
- Bootman
- Borgens
- Buonanno
- Ceccarelli
- Charbord
- Chawla
- Chen CH
- Chim
- Christina L. Ross
- Christopher D. Porada
- D'Souza
- Day
- De Mattei
- Den Dekker
- Dolmetsch
- Ermakov
- Fini
- Fitzsimmons
- Foletti
- Fu
- Funk
- Funk
- Gartzke
- George J. Christ
- Graça Almeida-Porada
- Guzelsu
- Hartig
- Harzheim
- Hastings
- Hess
- Hille
- Hotary
- Hotary
- Ikehara
- Jacobson
- Jacobson
- Jansen
- Jones
- Kaivosoja
- Kim
- Kim
- Kim
- Komori
- Konrad
- Levin
- Levin
- Levin
- Levin
- Liboff
- Lisi
- Lisi
- Litovitz
- Liu
- Liu
- Lohmann
- Luben
- Luo
- Mak
- Mayer-Wagner
- McGaig
- McLeod
- McLeod
- Mellstrom
- Metcalf
- Mevan Siriwardane
- Mobbs
- Mousavi
- Ng
- Nuccitelli
- Ongaro
- Otter
- Panagopoulos
- Parekh
- Persinger
- Persinger
- Peter Brink
- Petersen
- Pilla
- Poon
- Sacchetti
- Saino
- Sandyk
- Schroeder
- Schwartz
- Schwartz
- Scotti
- Serafini
- Sherwood
- Sun
- Sun
- Sun
- Sun
- Sundelacruz
- Sundelacruz
- Sundelacruz
- Takada
- Tenforde
- Trock
- Trock DH
- Tsai
- Tsai
- Volpe
- Yamada
- Yang
- Yoshida
- Yun JH
- Zhong
- Zimmerman
- Zimmerman
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Urine biomarkers in juvenile-onset SLE nephritis
- Author
- A El-Shehaby
- A Mak
- A Matrat
- A Midgley
- A Podolskaya
- A Ravelli
- A Viau
- A Woolf
- A Yilmaz
- AA Jesus
- AB Sanz
- AM Hammad
- AO Hersh
- BH Rovin
- Biomarkers Definitions Working Group
- C Bombardier
- C Eriksson
- CC Szeto
- CH Hinze
- CM Florkowski
- D Askenazi
- D Erdener
- DA Isenberg
- DD Gladman
- DM Fine
- E Akhter
- E Tarabra
- EM Tan
- G Moroni
- G Wang
- GE Norby
- GJ Pons-Estel
- GJ Schwartz
- H Trachtman
- H Yokoyama
- HI Brunner
- HI Brunner
- I Kazyra
- J Lu
- JA Gwira
- JJ Weening
- JM Esdaile
- JM Gardner-Medwin
- JW Bauer
- K Matoba
- L Christopher-Stine
- L Watson
- LB Tucker
- LM Campos
- Louise Watson
- LT Hiraki
- M Haase
- M Levy
- M Suzuki
- M Suzuki
- M Suzuki
- ME Hollmen
- MI Abd-Elkareem
- Michael W. Beresford
- MJ Siedner
- N Dhaun
- N Hiramatsu
- N Kasitanon
- N Schwartz
- OE Ayodele
- Q Fu
- R Marini
- R Mina
- R Pepper
- R Sesso
- RA Cottiero
- RW Chan
- RW Chan
- S Hagelberg
- S Nasiri
- S Skalova
- SA Varghese
- SD Marks
- SD Marks
- SD Marks
- SD Marks
- SM Al-Mayouf
- T Rubinstein
- T Wada
- TR Welch
- X Zhang
- Y Avihingsanon
- Y Avihingsanon
- Y Katsumata
- Y Molad
- YY Leung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
- Author
- A Arias-Vasquez
- A Bellucci
- A Cagnin
- A Goris
- A Iranzo
- A Kapasi
- A Lenka
- A Rongve
- A Schneeberger
- A Stuendl
- A Thaler
- AD Korczyn
- AD Korczyn
- AE Elia
- AH Simonsen
- AJ Harding
- AL Bergstrom
- American Psychiatric Association
- Amos D. Korczyn
- AP Gatt
- AP Strafella
- AW Lemstra
- B Dubois
- B Mollenhauer
- B Spencer
- BF Boeve
- BF Boeve
- BN Dugger
- BP Boot
- BS Connolly
- C Ballard
- C Gaig
- C Kun-Rodrigues
- C Labbè
- C Marras
- C Nombela
- C Ruffmann
- C Sanchez-Castaneda
- C Seer
- C Stinton
- CF Lippa
- CG Goetz
- CG Goetz
- CH Lin
- CH Williams-Gray
- CH Williams-Gray
- CH Williams-Gray
- CM Muller
- D Aarsland
- D Aarsland
- D Aarsland
- D Aarsland
- D Aarsland
- D Aarsland
- D Berg
- D Galasko
- D Mengel
- D Tsuang
- DB Hogan
- DG Healy
- DH Ffytche
- DH Hepp
- DH Hepp
- DJ Brooks
- DJ Burn
- DJ Irwin
- DJ Irwin
- DJ Irwin
- DR Howlett
- DW Dickson
- E Ghebremedhin
- E Mak
- E Mori
- E Noe
- E Sidransky
- EJ Burton
- ER Foster
- F Blanc
- F Longhena
- F Sakamoto
- G FĂ©nelon
- G Halliday
- G Halliday
- G Liu
- GJ Elder
- GM Halliday
- GM Halliday
- GM Halliday
- GM Halliday
- H Braak
- H Braak
- H Braak
- H Fujishiro
- H Garn
- H Hall
- H Nakashima-Yasuda
- H Shimada
- HF Wang
- HP Vranova
- I Alafuzoff
- I Guella
- I Gungor
- I Johar
- I Litvan
- I McKeith
- I McKeith
- I Rektorova
- I van Steenoven
- IF Mata
- IF Mata
- IG McKeith
- IG McKeith
- IG McKeith
- IH Richard
- J De Reuck
- J Fuchs
- J Graff-Radford
- J Graff-Radford
- J Johnson
- J Meireles
- J Pagonabarraga
- J Pagonabarraga
- J Simon-Sanchez
- J Zaccai
- JA Fields
- JB Anang
- JC Klein
- JE Lee
- JF Gagnon
- JF Morley
- JG Goldman
- JG Goldman
- JH Friedman
- JH Somme
- JH Yoon
- JO Aasly
- JT Burchell
- JT Geiger
- JT Lamberts
- JT O'Brien
- K Bronnick
- K Del Tredici
- K Dujardin
- K Frei
- K Hodges
- K Kosaka
- K Marder
- K Nishioka
- K Nishioka
- K Obi
- K Seidel
- K Seppi
- K Stubendorff
- K Wu
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KA Jellinger
- KE McAleese
- KE Paleologou
- KG Prakash
- KS Hwang
- Kurt A. Jellinger
- KW Park
- L Bonanni
- L Bonanni
- L Burghaus
- L Christopher
- L Harper
- L Iaccarino
- L Li
- L Parkkinen
- L Sarro
- L Walker
- LA Hansen
- LJM Vergouw
- LM Chahine
- LM Collins
- LN Clark
- M Colom-Cadena
- M Colom-Cadena
- M Emre
- M Goedert
- M Ikeda
- M Marquie
- M Marquie
- M Oinas
- M Petrou
- M Sierra
- M Swirski
- M Takemoto
- M Yoshita
- M Zarei
- MA Hely
- MA Hely
- ME Kalaitzakis
- ME Kalaitzakis
- MJ Firbank
- MK Beyer
- MM Williams
- MW Kurz
- MW Kurz
- MY Davis
- N Aoki
- N Seto-Salvia
- N Seto-Salvia
- N Tsuno
- NE Fritz
- NI Bohnen
- NI Bohnen
- NK Archibald
- NL Rey
- NP Visanji
- O Hansson
- OP Almeida
- P Brundin
- P Edison
- P Eusebi
- P Garcia-Esparcia
- P Jokinen
- P Martinez-Martin
- P Svenningsson
- P Tiraboschi
- P Tiraboschi
- PA Kempster
- PC Donaghy
- PG Ince
- PJ Lockhart
- PT Francis
- PT Kotzbauer
- Q Zhang
- R Barber
- R Biundo
- R Dodel
- R Frigerio
- R Guerreiro
- R Guerreiro
- R Inzelberg
- R Savica
- R Savica
- R Watson
- R Watson
- RA Barker
- RB Postuma
- RB Postuma
- RE Burke
- RE Skogseth
- RL Walton
- RN Alcalay
- RS Akhtar
- RS Desikan
- RS Weil
- S Delli Pizzi
- S Garcia-Ptacek
- S Gazzina
- S Goldwurm
- S Karantzoulis
- S Lerche
- S Molloy
- S Srivatsal
- S Varanese
- SE Winder-Rhodes
- SE Winder-Rhodes
- SJ Colloby
- SJ Colloby
- SKL Darweesh
- SM Fereshtehnejad
- SN Gomperts
- SN Gomperts
- SN Gomperts
- SN Gomperts
- SW Kim
- SW Yong
- T Foltynie
- T Fukui
- T Homma
- T Ikeuchi
- T Konno
- T Lashley
- T Oeda
- T Sobow
- T Uchihara
- TG Beach
- TJ Ferman
- TL Spires-Jones
- U Saeed
- U Walter
- UP Mosimann
- UP Mosimann
- V Deramecourt
- V Shanker
- WC Nichols
- WJ Schulz-Schaeffer
- WS Kim
- X Huang
- Y Chiba
- Y Compta
- Y Compta
- Y Huang
- Y Tsuboi
- Y Tsuboi
- Z Liu
- Z Nedelska
- Z Walker
- Z Walker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Schottky Diodes
- Author
- A Anastassiou
- A Bohg
- A Bradshaw
- A Deneuville
- A Martinez
- A McLay
- A Morino
- A Morino
- A Moser
- A Rusu
- A Shepela
- A Thanailakis
- A Thanailakis
- A Thanailakis
- A Thanailakis
- A Wortmann
- A Yamashita
- A Zaklikiewicz
- AA Gutkin
- AA Lebedev
- AA Vilisov
- AB Almazov
- AC MacPherson
- AC Macpherson
- AC Macpherson
- AG Bert
- AG Milnes
- AH Wilson
- AHF Muggleton
- AI Lakatos
- AJ Learn
- AJ Tuzzolino
- AK Ghosh
- AK Sinha
- AK Sinha
- AK Sinha
- AK Tereshchenko
- AK Wortmann
- AM Cowley
- AM Cowley
- AM Cowley
- AM Cowley
- AM Goodman
- AM Goodman
- AM Goodman
- AM Goodman
- AM Goodman
- AM Patwari
- AN Chandorkar
- AN Daw
- AN Korol
- AN Korol
- AN Saxena
- AN Zyuganov
- Anon.
- Anon.
- Anon.
- AP Vyatkin
- AR Adams
- AR Banerjee
- AT Akobirova
- AV Walker
- AW Chang
- AW Livingstone
- AW Livingstone
- AY Cho
- AYC Yu
- AYC Yu
- AYC Yu
- AYC Yu
- AYC Yu
- B Glance
- B Griffiths
- B Hamilton
- B Hoeneisen
- B Kurz
- B Pellegrini
- B Pellegrini
- B Pellegrini
- B Pietoulet
- BA Bobylev
- BL Crowder
- BL Smith
- BL Smith
- BL Smith
- BL Smith
- BL Smith
- BL Smith
- BL Smith
- BL Smith
- BL Smith
- BL Weiss
- BR Gossick
- BR Gossick
- BR Pruniaux
- BR Pruniaux
- BR Sood
- BV Tsarenko
- BV Tsarenkov
- BV Tsarenkov
- BV Tsarenkov
- C Barret
- C Barret
- C Barret
- C Barret
- C Barret
- C Barret
- C Cavinaugh
- C Chao
- C Dragone
- C Guinet
- C Guinet
- C Hassayer
- C Kim
- C Opdorp van
- C Pickering
- C Yeh
- CA Licchti
- CA Liechti
- CA Liechti
- CA Mead
- CA Mead
- CA Mead
- CA Mead
- CA Mead
- CA Mead
- CA Mead
- CA Mead
- CA Stolte
- CA Stolte
- CAT Salama
- CB Duke
- CB Duke
- CB Duke
- CC Tseng
- CE Burton
- CG Fonstad
- CH Wei
- CI Huang
- CI Huang
- CI Huang
- CK Kim
- CL Anderson
- CL Bertin
- CR Crovell
- CR Crovell
- CR Crovell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Crowell
- CR Wronski
- CR Wronski
- CT Sah
- CT Sah
- CT Wang
- CW Scheffer
- CY Chang
- CY Chang
- D Bois
- D Jager
- D Jager
- D Kahng
- D Kahng
- D Kahng
- DA Hodges
- DA Neamen
- DA Neamen
- DE Cullen
- DE Eastman
- DE Fulkerson
- DG Puntenney
- DJ Bates
- DJ Coleman
- DJ Coleman Jr.
- DJ Page
- DK Donald
- DK Hohnke
- DK Jadus
- DL Losee
- DL Losee
- DL Losee
- DL Scharfetter
- DL White
- DM Bercha
- DP Kennedy
- DP Kennedy
- DR Decker
- DT Kan
- DT Young
- DU Geppert
- DV Geppert
- DW Moore
- E Courteas
- E Demoulin
- E Fabre
- E Kadrnka
- E Kohn
- E Kohn
- E Kohn
- E Munoz-Merino
- EG Melikyan
- EG Melikyan
- EH Rhoderick
- EH Rhoderick
- EL Murphy
- EL Wolf
- EL Wolf
- EL Wolf
- EM Logothetis
- EO Kane
- ES Artobolevskaya
- F Flores
- F Forlain
- F Forlani
- F Steinrisser
- F Yndurain
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FA Padovani
- FD Hughes
- FH Gaensslen
- FJ Landkammer
- FJ Landkammer
- FJ Landkammer
- FJ Walter
- FM Charbonnier
- FP Califano
- FW Hewlett Jr.
- G Baccarani
- G Binnig
- G Fuchs
- G Goto
- G Kano
- G Kano
- G Kano
- G Lubberts
- G Lubberts
- G Schreder
- G Schreder
- G Vincent
- G Zeidenbergs
- GA Armantrout
- GA Dussel
- GA May
- GB Abdullaev
- GB Seiranyan
- GB Seiranyan
- GB Seiranyan
- GB Seiranyan
- GB Seitanyan
- GD Mahan
- GD Mahan
- GD Mey
- GE Chaika
- GE Morris
- GE Stillman
- GE Stillman
- GF Guhman
- GH Glover
- GH Glover
- GH Glover
- GH Glover
- GH Parker
- GH Parker
- GH Swallow
- GI Roberts
- GI Roberts
- GI Roberts
- GJ Miller
- GL Pearson
- GM Semenov
- GP Peka
- GS Nadkarni
- GW Eimers
- GW Hughes
- GW Hughes
- GW Neudeck
- GW Neudeck
- GY Chaika
- GY Robinson
- H Diehl
- H Flietner
- H Fritzsche
- H Harreis
- H Heymann
- H Holloway
- H Hoshino
- H Iizuka
- H Jager
- H Jager
- H Klose
- H Klose
- H Klose
- H Kniepkamp
- H Matino
- H Okamoto
- H Sonomura
- H Statz
- H Teshima
- H Tippmann
- H Vogel
- H Yanai
- H Yanai
- HA Haus
- HA Lindsey
- HC Card
- HC Card
- HC Card
- HC Card
- HC Card
- HC Card
- HC Card
- HC Huang
- HE Elder
- HF Cooke
- HG White
- HH Berger
- HHJ Kanerva
- HJ Hovel
- HJ Kuno
- HJ Peppiatt
- HJ Strobel
- HJJ Man De
- HJJ Man De
- HK Bucher
- HK Henisch
- HL Malm
- HL Stover
- HM Day
- HM Day
- HM Day
- HM Olson
- HM Rein
- HN Yu
- HP Wagner
- HPD Lanyon
- HR Fetterman
- HR Fetterman
- HT Minden
- HT Minden
- I Ames
- I Drukier
- I Tatsuguchi
- IA Radzievskii
- IC Lim
- J Antula
- J Balazs
- J Bardeen
- J Basterfield
- J Cervenak
- J Cervenak
- J Cohen
- J Dorler
- J Dorler
- J Edrich
- J Graffeuil
- J Gu
- J Jahneke
- J Jehnicka
- J Jimenez
- J Karpinsky
- J Klamka
- J Klamka
- J Krempasky
- J Nakai
- J Narain
- J Ohura
- J Piqueras
- J Pokorny
- J Rattner
- J Touskova
- J Touskova
- J Touskova
- JA Assimos
- JA Copeland
- JA Copeland
- JA Grimshaw
- JA Love
- JA Pals
- JA Pals
- JA Scott-Monck
- JB Angell
- JC Inkson
- JC Inkson
- JC Inkson
- JC Irvin
- JC Irvin
- JC Phillips
- JC Phillips
- JC Phillips
- JD Buchs
- JD Buchs
- JD Buchs
- JD Levine
- JD Levine
- JE Carnes
- JE Carroll
- JE Christopher
- JG Gardiner
- JG Gardiner
- JG Gardiner
- JG Hogeboom
- JG Simmons
- JGAM Dries van den
- JGAM Dries van den
- JIB Wilson
- JJ Uebbing
- JK Toda
- JL Moll
- JM Andrews
- JM Andrews
- JM Caywood
- JM Lavine
- JM Pawlikowski
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- VV Makarov
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- VY Nishov
- W Anacker
- W Baechtold
- W Baechtold
- W Baechtold
- W Baechtold
- W Baechtold
- W Baechtold
- W Baechtold
- W Gwarek
- W Henne
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- WM Honig
- WM Sharpless
- WP Dumke
- WP Noble Jr.
- WR Wisseman
- WT Lindley
- WVT Rusch
- WW Siekanowicz
- Y Anand
- Y Anand
- Y Anand
- Y Anand
- Y Anand
- Y Anand
- Y Furukawa
- Y Furukawa
- Y Furukawa
- Y Itoh
- Y Itoh
- Y Nannichi
- Y Nannichi
- Y Sato
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- Y Zohta
- YA Goldberg
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- Z Majewski
- Z Sroubek
- Z Sroubek
- Z Sroubek
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1976
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
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- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
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- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
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- Balaguera J
- Balcells E
- Baldari D
- Baldus S
- Bali H
- Ballantyne C
- Ballmer P
- Banerjee S
- Bang-Hansen T
- Banikova A
- Bankowski D
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- Bansal M
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- Bartels GL
- Basilio E
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- Bassand J
- Bassand JP
- Bassand JP
- Basso V
- Bata I
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- Battin D
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- Bautista J
- Bayat J
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- Beloscar J
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- Beltrano MC
- Ben-Aharon J
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- Benetar J
- Bengtsson PO
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- Berezniakov I
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- Bergeron J
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- Bernardi D
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- Bhalla H
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- Bhargava R
- Bhargavi M
- Bhesania T
- Biasucci L
- Biedermann B
- Bikkina M
- Bilazarian S
- Bilodeau N
- Bin Ismail O
- Binaghi G
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- Bittel B
- Bitzer V
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- Blais D
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- Blazing M
- Blazing M
- Blazing Michael A.
- Blessing E
- Block D
- Bluguermann J
- Blumberg E
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- Brady A
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- Braunwald Eugene
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- Brussee H
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- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
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- Canto J
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- Christy L
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- Cubeddu L
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- Cyncar R
- D'Urso M
- da Costa FA
- da Cunha C
- Dagefoerde N
- Dahiya R
- Dalby A
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- Dale H
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- Damiano M
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- Dani S
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- Danse IY
- Darcel I
- Darius H
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- Darnell Z
- Dauber I
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- Dawson G
- De Andrade M
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- de Carvalho Moreira R
- De Caterina R
- De Clippel M
- De Feo S
- De Ferrari G
- De Ferrari G
- De Ferrari Gaetano M.
- De Ferrari GM
- De Gregorio M
- de la Guia F
- de la Guia F
- De Larochelliere R
- de Lemos J
- De Lemos J
- De Lucca Paul
- De Maria E
- de Sa E
- de Salazar D
- de Souza J
- de Teresa E
- de Valdecilla H
- De Velder L
- De Wolf L
- Debrouwer K
- Decker S
- DeFranco A
- Del Core M
- del Rio A
- Dela Cruz C
- Delahaye F
- Delgado J
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- Della Siega A
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- Dempsey K
- Den Hartog FR
- DeRaad R
- Desai V
- Desalca M
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- DeVault S
- Devlin G
- Dhooghe G
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- Diadema B
- Dias D
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- Dignen K
- Dijkshoorn-Giesen AH
- Dimenna J
- Diogo A
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- Dirkali A
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- Domingo D
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- Doughty A
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- Dourmap-Collas C
- Doux N
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- Drexel H
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- Escorihuela A
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- Esteban I
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- Fahdi I
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- Fielding M
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- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit