Dimensional Change Assessment Of Lyophilized Bovine Pericardium

[No abstract available]21141Maizato, M.J.S., Higa, O.Z., Mathor, M.B., Camillo, M.A.P., Spencer, P.J., Pitombo, R.N., Zavaglia, C.A.C., Leirner, A.A., Glutaraldehyde-treated bovine pericardium: Effects of lyophilization on citotoxicity and residual aldehydes (2003) Artificial Organs, 27, p. 69

Adherence And Growth Of Endothelial Cells On Silk Fibroin Dense Membranes

[No abstract available]2839Altman, G.H., Diaz, F., Jakuba, C., Calabro, T., Horan, R.L., Chen, J., Lu, H., Kaplan, D.L., Silkbased biomaterials (2003) Biomaterials, 24, p. 401Servoli, E., Maniglio, D., Motta, A., Predazzer, R., Migliaresi, C., Surface properties of silk fibroin films and their interaction with fibroblasts (2005) Macromol Biosci., 5, p. 1175Gupta, M.K., Khokhar, S.K., Phillips, D.M., Sowards, L.A., Drummy, L.F., Kadakia, M.P., Naik, R.R., Patterned silk films cast from ionic liquid solubilized fibroin as scaffolds for cell growth (2007) Langmuir, 23, p. 1315Fuchs, S., Motta, A., Migliaresi, C., Kirkpatrick, C.J., Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells as a potential source of autologous cells for endothelialization of silk fibroin biomaterials (2006) Biomaterials, 27, p. 5399Feugier, P., Black, R.A., Hunt, J.A., How, T.V., Attachment, morphology and adherence of human endothelial cells to vascular prosthesis materials under the action of shear stress (2005) Biomaterials, 26, p. 145

In Vivo Study Of Lyophilized Bioprostheses: 3 Month Follow-up In Young Sheep [estudo In Vivo Do Comportamento De Bioprótese Liofilizada: Seguimento De 3 Meses Em Carneiros Jovens]

Objective: Glutaraldehyde is currently used in bovine pericardium bioprosthesis to improve mechanical and immunogenic properties. Lyophilization is a process that may decrease aldehyde residues in the glutaraldehyde treated pericardium decreasing cytotoxicity and enhancing resistance to calcification. The aim of this study is to evaluate bioprosthetic heart valves calcification in adolescent sheep and to study the potential of lyophilization as a mechanism to protect calcification. Methods: Two groups were evaluated: a control group in which a bovine pericardium prosthetic valve was implanted in pulmonary position and a lyophilized group in which the bovine pericardium prosthetic valve was lyophilized and further implanted. Sixteen sheeps 6 months old were submitted to the operation procedure. After 3 months the sheeps were euthanized under full anesthesia. Results: Six animals of the control group reached 95.16 ± 3.55 days and six animals in the lyophilized group reached 91.66 ± 0.81 days of postoperative evolution. Two animals had endocarditis. Right ventricle/pulmonary artery (RV/PA) mean gradient, in the control group, at the implantation was 2.04 ± 1.56 mmHg, in the lyophilization group, the RV/PA mean gradient, at the implantation was 6.61 ± 4.03 mmHg. At the explantation it increased to 7.71 ± 3.92 mmHg and 8.24 ± 6.25 mmHg, respectively, in control and lyophilization group. The average calcium content, after 3 months, in the control group was 21.6 ± 39.12 μg Ca+2/mg dry weight, compared with an average content of 41.19 ± 46.85 μg Ca+2/mg dry weight in the lyophilization group (P=0.662). Conclusion: Freeze drying of the bovine pericardium prosthesis in the pulmonary position could not demonstrate calcification mitigation over a 3 month period although decreased inflammatory infiltration over the tissue.274592599Rahimtoola, S.H., Choice of prosthetic heart valve in adults an update (2010) J Am Coll Cardiol., 55 (22), pp. 2413-2426David, T.E., Armstrong, S., Maganti, M., Hancock II bioprosthesis for aortic valve replacement: The gold standard of bioprosthetic valves durability? (2010) Ann Thorac Surg., 90 (3), pp. 775-781Clark, J.N., Ogle, M.F., Ashworth, P., Bianco, R.W., Levy, R.J., Prevention of calcification of bioprosthetic heart valve cusp and aortic wall with ethanol and aluminum chloride (2005) Ann Thorac Surg., 79 (3), pp. 897-904Ruel, M., Kulik, A., Rubens, F.D., Bédard, P., Masters, R.G., Pipe, A.L., Late incidence and determinants of reoperation in patients with prosthetic heart valves (2004) Eur J Cardiothorac Surg., 25 (3), pp. 364-370Poirer, N.C., Pelletier, L.C., Pellerin, M., Carrier, M., 15-year experience with the Carpentier-Edwards pericardial bioprosthesis (1998) Ann Thorac Surg., 66 (6 SUPPL.), pp. S57-S61Duran, C.G., Gunning, A.J., Whitehead, R., Experimental aortic valve heterotransplantation (1967) Thorax., 22 (6), pp. 510-518Duran, C.M., Whitehead, R., Gunning, A.J., Implantation of homologous and heterologous aortic valves in prosthetic vascular tubes (1969) Thorax., 24 (2), pp. 142-147Borgognoni, C.F., Maizato, M.J., Leirner, A.A., Polakiewicz, B., Beppu, M.M., Higa, O.Z., Effect of freeze-drying on the mechanical, physical and morphological properties of glutaraldehyde-treated bovine pericardium: Evaluation of freeze-dried treated bovine pericardium properties (2010) J Appl Biomater Biomech., 8 (3), pp. 186-190Maizato, M.J., Higa, O.Z., Mathor, M.B., Camillo, M.A., Spencer, P.J., Pitombo, R.N., Glutaraldehyde-treated bovine pericardium: Effects of lyophilization on cytotoxicity and residual aldehydes (2003) Artif Organs., 27 (8), pp. 692-694Flameng, W., Meuris, B., Yperman, J., de Visscher, G., Herijgers, P., Verbeken, E., Factors influencing calcification of cardiac bioprostheses in adolescent sheep (2006) J Thorac Cardiovasc Surg., 132 (1), pp. 89-98Schoen, F.J., Levy, R.J., Calcification of tissue heart valve substitutes: Progress toward understanding and prevention (2005) Ann Thorac Surg., 79 (3), pp. 1072-1080McClure, R.S., Narayanasamy, N., Wiegerinck, E., Lipsitz, S., Maloney, A., Byrne, J.G., Late outcomes for aortic valve replacement with the Carpentier-Edwards pericardial bioprosthesis: Up to 17-year follow-up in 1,000 patients (2010) Ann Thorac Surg., 89 (5), pp. 1410-1416Jamieson, W.R., Lewis, C.T., Sakwa, M.P., Cooley, D.A., Kshettry, V.R., Jones, K.W., St Jude Medical Epic porcine bioprosthesis: Results of the regulatory evaluation (2011) J Thorac Cardiovasc Surg., 141 (6), pp. 1449e2-1454e2The Italian study on the Mitroflow postoperative results (ISTHMUS): A 20-year, multicentre evaluation of Mitroflow pericardial bioprosthesis (2011) Eur J Cardiothorac Surg., 39 (1), pp. 18-26. , ISTHMUS InvestigatorsBeauchamp Jr., R.O., St Clair, M.B., Fennell, T.R., Clarke, D.O., Morgan, K.T., Kari, F.W., A critical review of the toxicology of glutaraldehyde (1992) Crit Rev Toxicol., 22 (3-4), pp. 143-174Golomb, G., Schoen, F.J., Smith, M.S., Linden, J., Dixon, M., Levy, R.J., The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac valve bioprostheses (1987) Am J Pathol., 127 (1), pp. 122-130Guldner, N.W., Jasmund, I., Zimmermann, H., Heinlein, M., Girndt, B., Meier, V., Detoxification and endothelialization of glutaraldehyde-fixed bovine pericardium with titanium coating: A new technology for cardiovascular tissue engineering (2009) Circulation., 119 (12), pp. 1653-1660Clark, J.N., Ogle, M.F., Ashworth, P., Bianco, R.W., Levy, R.J., Prevention of calcification of bioprosthetic heart valve cusp and aortic wall with ethanol and aluminum chloride (2005) Ann Thorac Surg., 79 (3), pp. 897-904Hahn, S.K., Ohri, R., Giachelli, C.M., Anti-calcification of bovine pericardium for bioprosthetic heart valves after surface modi-fication with hyaluronic acid derivatives (2005) Biotechnol Bioprocess Eng., 10, pp. 218-224Zilla, P., Fullard, L., Trescony, P., Meinhart, J., Bezuidenhout, D., Gorlitzer, M., Glutaraldehyde detoxification of aortic wall tissue: A promising perspective for emerging bioprosthetic valve concepts (1997) J Heart Valve Dis., 6 (5), pp. 510-520Weissenstein, C., Human, P., Bezuidenhout, D., Zilla, P., Glutaraldehyde detoxification in addition to enhanced amine cross-linking dramatically reduces bioprosthetic tissue calcification in the rat model (2000) J Heart Valve Dis., 9 (2), pp. 230-240Santibáñez-Salgado, J.A., Olmos-Zúñiga, J.R., Pérez-López, M., Aboitiz-Rivera, C., Gaxiola-Gaxiola, M., Jasso-Victoria, R., Lyophilized glutaraldehyde-preserved bovine pericardium for experimental atrial septal defect closure (2010) Eur Cell Mater., 19, pp. 158-165Zilla, P., Brink, J., Human, P., Bezuidenhout, D., Prosthetic heart valvae: Catering for the few (2008) Biomaterials., 29 (4), pp. 385-40

Lyophilized Bovine Pericardium Coated With Silk Fibroin Solution As An Alternative To Prevent Calcification Of Cardiovascular Bioprosthesis: Preliminary Calcification Results

[No abstract available]1509Pettenazzo, E., Dynamic in vitro calcification of bioprosthetic porcine valves: Evidence of apatite crystallization (2001) The Journal of Thoracic and Cardiovascular Surgery, 121 (3), pp. 500-509Aimoli, C.G., Lyophilized bovine pericardium treated with a phenethylaminediepoxide as an alternative to preventing calcification of cardiovascular bioprosthesis: Preliminary calcification results (2007) Artificial Organs, 31 (4), pp. 278-28