Current status of research and application in vascular stents

Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years' development of vascular stents, revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged. In this review, the evolution of vascular stents is summarized, aiming to provide a glimpse into the future of vascular stents. Advanced designs, focusing on the investigations of new substrates, new platforms, new drugs and new biomolecules are currently under evaluation with promising clinical studies. The concept of "time sequence functional stent" has been raised in this paper. It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization. It also shows long-term inertness without release of toxic ions or toxic degradation products. The success of this concept is briefly presented with a clinical study in this model stents

Full thickness facial burns: outcomes following orofacial rehabilitation

Purpose: To document orofacial rehabilitation and outcomes after full thickness orofacial burn

„A szent ügy”

“The sacred affair”: Linguistic analysis of the propaganda disseminated in the dualistic era (1867–1918) concerning the Magyarization of names Official family name changes are often induced by practical, biographical causes. The fact that the original surname may become stigmatized by language and name ideology can also be observed as contributing to the phenomenon. This last case can be exemplified by the 19th century mass movement for the Magyarization of foreign names in Hungary, especially in communities whose members bore surnames of German origin. This movement could not have happened if linguistic nationalism, the dominant language ideology of the era, had not viewed family names as national symbols serving national-political purposes. This paper offers a critical discourse analysis of the propaganda for the Magyarization of names, which in the second half of the 19th century aimed at spreading and enacting the so-called “national name ideology”. The analysis primarily explores those discourse strategies (ideological contents and their linguistic representations) by which people bearing surnames of non Hungarian origin were made to accept the idea of national name ideology and convinced to Magyarize their family names

Teaching mechanics with individual exercise assignments and automated correction

Solving exercise problems by yourself is a vital part of developing a mechanical understanding. Yet, most mechanics lectures have more than 200 participants, so the workload for manually creating and correcting assignments limits the number of exercises. The resulting example pool is usually much smaller than the number of participants, making verifying whether students can solve problems themselves considerably harder. At the same time, unreflected copying of tasks already solved does not foster the understanding of the subject and leads to a false self-assessment. We address these issues by providing a scalable approach for creating, distributing, and correcting exercise assignments for problems related to statics, strength of materials, dynamics, and hydrostatics. The overall concept allows us to provide individual exercise assignments for each student. A quantitative survey among students of our recent statics lecture assesses the acceptance of our teaching tool. The feedback indicates a clear added value for the lecture, which fosters self-directed and reflective learning

Severity of symptoms of European stone fruit yellows on different apricot varieties

Apricot is an important fruit crop in Hungary. There are large growing areas consisted of orchards of different sizes. These orchards are highly affected by a disease complex the so cold apoplexy with its characteristic symptoms. In this study, the effect of rootstocks and scion varieties on the severity of symptoms was investigated in an apricot orchard near Budapest. Symptoms were assessed in autumn at their most characteristic appearance on the combinations of 5 different scion varieties and 3 different rootstocks in 3 consecutive growing seasons. According to the results of the assessments in most cases, symptoms proved to be more frequent and stronger on trees grown on wild apricot rootstock than on plum intergrafted or myrobalan rootstocks. The variety Mandulakajszi proved to be consistently the least affected variety particularly on plum intergrafted rootstocks. Severity of symptoms observed on other investigated varieties deviated depending on the different rootstocks and growing seasons. To reduce the effect of growing seasons monitoring should be continued. &nbsp

Bio-responsive polymer hydrogels homeostatically regulate blood coagulation

Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which - in turn - becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches blood coagulation over several hours in the presence of pro-coagulant stimuli and during repeated incubation with fresh, non-anticoagulated blood. These features enable the introduced material to provide sustainable, autoregulated anticoagulation, addressing a key challenge of many medical therapies. Beyond that, the explored concept may facilitate the development of materials that allow the effective and controlled application of drugs and biomolecules