491 research outputs found
Entanglement of a Mesoscopic Field with an Atom induced by Photon Graininess in a Cavity
We observe that a mesoscopic field made of several tens of microwave photons
exhibits quantum features when interacting with a single Rydberg atom in a
high-Q cavity. The field is split into two components whose phases differ by an
angle inversely proportional to the square root of the average photon number.
The field and the atomic dipole are phase-entangled. These manifestations of
photon graininess vanish at the classical limit. This experiment opens the way
to studies of large Schrodinger cat states at the quantum-classical boundary
Stem cells and physical energies: can we really drive stem cell fate?
Adult stem cells are undifferentiated elements able to self-renew or differentiate to maintain tissue integrity. Within this context, stem cells are able to divide in a symmetric fashion, feature characterising all the somatic cells, or in an asymmetric way, which leads daughter cells to different fates. It is worth highlighting that cell polarity have a critical role in regulating stem cell asymmetric division and the proper control of cell division depends on different proteins involved in cell development, differentiation and maintenance of tissue homeostasis. Moreover, the interaction between cells and the extracellular matrix are crucial in influencing cell behavior, included in terms of mechanical properties as cytoskeleton plasticity and remodelling, and membrane tension. Finally, the activation of specific transcriptional program and epigenetic modifications contributes to cell fate determination, through modulation of cellular signalling cascades. It is well known that physical and mechanical stimuli are able to influence biological systems, and in this context, the effects of electromagnetic fields (EMFs) have already shown a considerable role, even though there is a lack of knowledge and much remains to be done around this topic. In this review, we summarize the historical background of EMFs applications and the main molecular mechanism involved in cellular remodelling, with particular attention to cytoskeleton elasticity and cell polarity, required for driving stem cell behavior
Risk-Informed design process of the IRIS reactor
Westinghouse is currently conducting the pre-application licensing of the International Reactor Innovative and
Secure (IRIS). The design philosophy of the IRIS has been based on the concept of Safety-by-DesignTM and within this
framework the PSA is being used as an integral part of the design process. The basis for the PSA contribution to the design
phase of the reactor is the close iteration between the PSA team and the design and safety analysis team. In this process the
design team is not only involved in the initial phase of providing system information to the PSA team, allowing in this way the
identification of the high risk scenarios, but it is also receiving feedback from the PSA team that suggests design modification
aimed at reaching risk-related goals.
During the first iteration of this process, the design modifications proposed by the PSA team allowed reducing the initial
estimate of Core Damage Frequency (CDF) due to internal events from 2E-6/ry to 2E-8/ry. Since the IRIS design is still in a
development phase, a number of assumptions have to be confirmed when the design is finalized.
Among key assumptions are the success criteria for both the accident sequences analyzed and the systems involved in the
mitigation strategies. The PSA team developed the initial accident sequence event trees according to the information from
the preliminary analysis and feasibility studies. A recent coupling between the RELAP and GOTHIC codes made possible the
actual simulation of all LOCA sequences identified in the first draft of the Event Trees. Working in close coordination, the
PSA and the safety analysis teams developed a matrix case of sequences not only with the purpose of testing the assumed
success criteria, but also with the perspective of identifying alternative sequences developed mainly by relaxing the extremely
conservative assumptions previously made.
The results of these simulations, bounded themselves with conservative assumptions on the Core Damage definition,
suggested two new versions of the LOCA Event Tree with two possible configurations of the Automatic Depressurization
System. The new CDF has been evaluated for both configurations and the design team has been provided with an additional
and risk-related perspective that will help choosing the design alternative to be implemented
Unravelling cellular mechanisms of stem cell senescence: An aid from natural bioactive molecules
Cellular senescence plays a role in the onset of age-related pathologies and in the loss of tissue homeostasis. Natural compounds of food or plants exert an important antioxidant activity, counteracting the formation of harmful free radicals. In the presence of an intense stressing event, cells activate specific responses to counteract senescence or cell death. In the present paper, we aimed at evaluating the levels of expression of specific markers of senescence, in order to demonstrate that extracts from Myrtus Communis L. can prevent premature senescence in ADSCs exposed to oxidative stress. Cells were cultured in the presence of Myrtus extracts for 12â24 and 48 h and then incubated with H2O2 to induce senescence. We then evaluated the expression of senescence-related markers p16, p19, p21, p53, TERT, c-Myc, and the senescence-associated ÎČ-Galactoidase activity. Our results showed that pre-treatment with Myrtus extracts protects cells from premature senescence, by regulating the cell cycle, and inducing the expression of TERT and c-Myc. These findings suggest a potential application of these natural compounds in the prevention and treatment of various diseases, counteracting premature senescence and preserving tissue functions
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