Multiple tidal disruption flares in the active galaxy IC 3599

Tidal disruption events occur when a star passes too close to a massive black hole and it is totally ripped apart by tidal forces. It may also happen that the star is not close enough to the black hole to be totally disrupted and a less dramatic event might happen. If the stellar orbit is bound and highly eccentric, just like some stars in the centre of our own Galaxy, repeated flares should occur. When the star approaches the black hole tidal radius at periastron, matter might be stripped resulting in lower intensity outbursts recurring once every orbital period. We report on Swift observations of a recent bright flare from the galaxy IC 3599 hosting a middle-weight black hole, where a possible tidal disruption event was observed in the early 1990s. By light curve modelling and spectral fitting we can consistently account for the events as the non-disruptive tidal stripping of a star into a highly eccentric orbit. The recurrence time is 9.5 yr. IC 3599 is also known to host a low-luminosity active galactic nucleus. Tidal stripping from this star over several orbital passages might be able to spoon-feed also this activity.Comment: Accepted for publication to Astronomy & Astrophysic

Impact of RFID and EPCglobal on Critical Processes of the Pharmaceutical Supply Chain

The need to implement and guarantee effective item-level tracing systems is becoming more and more important for a wide range of business applications, such as manufacturing, logistics, healthcare, and anti-counterfeiting. Among these, the pharmaceutical supply chain, with millions of medicines moving around the world and needing to be traced at item level, represents a very interesting reference scenario. Furthermore, the growing counterfeiting problem raises a significant threat within the supply chain system. Recently, several international institutions (e.g. Food and Drug Administration, European Medicines Agency, European Federation of Pharmaceutical Industries and Associations, GS1) are encouraging the use of innovative solutions in healthcare and in the pharmaceutical supply chain, to improve patient safety and enhance the efficiency of the pharmaceutical supply chain, with better worldwide drug traceability

Hand Rehabilitation and Telemonitoring through Smart Toys

We describe here a platform for autonomous hand rehabilitation and telemonitoring of young patients. A toy embedding the electronics required to sense fingers pressure in different grasping modalities is the core element of this platform. The system has been realized following the user-centered design methodology taking into account stakeholder needs from start: clinicians require reliable measurements and the ability to get a picture remotely on rehabilitation progression; children have asked to interact with a pleasant and comfortable object that is easy to use, safe, and rewarding. These requirements are not antithetic, and considering both since the design phase has allowed the realization of a platform reliable to clinicians and keen to be used by young children

Using Virtual Reality to Rehabilitate Neglect

Purpose: Virtual Reality (VR) platforms gained a lot of attention in the rehabilitation field due to their ability to engage patients and the opportunity they offer to use real world scenarios. As neglect is characterized by an impairment in exploring space that greatly affects daily living, VR could be a powerful tool compared to classical paper and pencil tasks and computer training. Nevertheless, available platforms are costly and obstructive. Here we describe a low cost platform for neglect rehabilitation, that using consumer equipments allows the patient to train at home in an intensive fashion. Method: We tested the platform on IB, a chronic neglect patient, who did not benefit from classical rehabilitation. Results: Our results show that IB improved both in terms of neglect and attention. Importantly, these ameliorations lasted at a follow up evaluation 5 months after the last treatment session and generalized to everyday life activities. Conclusions: VR platforms built using equipment technology and following theoretical principles on brain functioning may induce greater ameliorations in visuo-spatial deficits than classical paradigms possibly thanks to the real world scenarios in association with the "visual feedback" of the patient's own body operating in the virtual environmen

A Cloud Telemedicine Platform Based on Workflow Management System: A Review of an Italian Case Study

The paper aims to describe a new technological and organizational approach in order to manage teleconsultation and telemonitoring processes involving a Physician, who remotely interacts with one or more Specialists, in order to evaluate and discuss the specific clinical conditions of a patient, based primarily on the sharing of digital clinical data, reports and diagnostic images. In the HINT project (Healthcare INtegration in Telemedicine), a teleconsultation and telemonitoring cloud platform has been developed using a Hub and Spoke architecture, based on a Business Process Management System (BPMS). The specialized clinical centres (Hubs) operate in connection with the territorial hospital centres (Spokes), which receive specific diagnostic consultations and telemonitoring data from the appropriate Specialist, supported by advanced AI systems. The developed platform overcomes the concepts of a traditional and fragmented teleconsultation and consequently the static organization of Hubs and Spokes, evolving towards an integrated clinical workflow management. The project platform adopts international healthcare standards, such as HL7 FHIR, IHE (XDS and XDW) and DICOM for the acquisition and management of healthcare data and diagnostic images. A Workflow Management System implemented in the platform allows to manage multiple and contemporaneous processes through a single platform, correctly associating the tasks to the Physicians responsible for their execution, monitoring the status of the health activities and managing possible clinical issues