USING BAYESIAN STATISTICAL POSTPROCESSING METHODS TO IMPROVE LOCAL WIND FORECASTS

This thesis explores the use of Bayesian statistical postprocessing to rapidly train a highly accurate forecast from a 1 km resolution gridded WRF model forecast over a 100 km by 100 km area. These methods leverage three modeled forecast variables—10 m winds, sea-level pressure, and terrain elevation—in conjunction with downstream observations and prior model runs to identify model inaccuracies. Using only three days of data, a Bayesian corrected forecast is produced and analyzed for accuracy and improvement over the original model run relative to real-world observations. Over 90% of the resulting forecasts saw improvement over the raw model forecasts in root mean squared error, and over 87% of the forecasts saw improvement in mean error over the raw model forecasts. Extreme circumstances saw improvements in accuracy of over 9 knots while overall improvements were reliably seen both in accuracy and precision among Bayesian corrected forecasts. These findings are significant as they suggest that Bayesian statistical postprocessing methods work and should be both employable at rapid rates, and result in more accurate forecasts.First Lieutenant, United States Air ForceApproved for public release. distribution is unlimite

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele