A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging

An electronically active and spectral sensitive fluorescent “turn-on” chemosensor (BTP-1) based on the benzo-thiazolo-pyrimidine unit was designed and synthesized for the highly selective and sensitive detection of Fe³⁺ from aqueous medium. With Fe³⁺, the sensor BTP-1 showed a remarkable fluorescence enhancement at 554 nm (λex=314 nm) due to the inhibition of photo-induced electron transfer. The sensor formed a host-guest complex in 1:1 stoichiometry with the detection limit down to 0.74 nM. Further, the sensor was successfully utilized for the qualitative and quantitative intracellular detection of Fe³⁺ in two liver cell lines i.e., HepG2 cells (human hepatocellular liver carcinoma cell line) and HL-7701 cells (human normal liver cell line) by a confocal imaging technique

The amidine based colorimetric sensor for Fe³⁺, Fe²⁺, and Cu²⁺ in aqueous medium

An amidine based chemosensor AM-1 was synthesized and characterized by various spectroscopic (FT-IR, 1H-NMR and mass) data and elemental analyses. Sensor AM-1 exhibited high selectivity and sensitivity towards Fe³⁺, Fe²⁺ and Cu²⁺ in the presence of other surveyed ions (such as Sr²⁺, Cr³⁺, Co²⁺, Ni²⁺, Zn²⁺, Ag⁺, Al³⁺, Ba²⁺, Ca²⁺, Cd²⁺, Cs⁺, Hg²⁺, K⁺, Li⁺, Mg²⁺, Mn²⁺, Na⁺ and Pb²⁺) with a distinct naked-eye detectable color change and a shift in the absorption band. Moreover, the emission of AM-1 was quenched selectively only in the presence of Fe³⁺

<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">Eco-friendly Pest Management Using Monoterpenoids-III: Antibacterial Efficacy of Carvacrol Derivatives^#</span>

1086-1089<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:black;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Monoterpenoids are the natural products having pest management potency against different agricultural as well as public health pests. Ether and ester derivatives of carvacrol, [2-methyl-5- (1-methyl ethyl) phenol], a natural phenolic monoterpenoid, were synthesized and evaluated for their antibacterial activity against B.megaterium, B.japonicum ,B.polymyxa and B. substilits to establish structure-activity relationships. In overall studies, carvacrol esters exhibited better antibacterial potency and efficacy than ethers. An introduction of aliphatic side chains with increasing methylene group and olefine double bond reflected least effect on activity. However, aromatic moiety, additional olefinic bond and also carboxylic group in the side chain resulted in the compounds with improved and better antibacterial potency over the parent molecule.</span

Synthesis of 4-(2-(substituted phenyl)diazenyl)-1-phenylpyrazolidine-3,5-dione catalyzed by <img src='http://www.niscair.res.in/jinfo/small.gif' border=0>-proline and their biological activity

1208-1212-Proline as an efficient and eco-friendly catalyst has been employed for the synthesis of 4-(2-(substitutedphenyl)-diazenyl)-1-phenylpyrazolidine-3,5-dione from diethyl 2-(2-(substitutedphenyl)-hydrazono)malonate and phenyl hydrazine. This protocol exhibits advantages like high catalytic efficiency, shorter reaction time and easy isolation of products. The synthesized compounds have been structurally characterized on the basis of IR, 1H and 13C NMR, mass spectroscopy and elemental analyses. All of the newly isolated compounds have been tested for their antibacterial activities. The antibacterial screening using the agar well diffusion method reveals that the fluro derivative 3e is the most active one

Eco-friendly Pest Management Using Monoterpenoids II—Antifungal Efficacy of Menthol Derivatives

990-995<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:black;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Ether and ester derivatives of menthol, [5-methyl-2-(1-methylethyl) cyc1o hexanol] , a natural monoterpenoid are synthesized and evaluated for antifungal potency against Aspergillus niger, Aspergillus oryzae, Fusarium oxysporum , and Alternaria alternata to study structure activity relationships. Ethylene dimer ether derivative is observed to be the most potent against all fungal species. Benzyl ether derivative is found to be more active than allyl ether derivative. In simple esters, cinnamate derivative is more activity enhancing against Aspergillus oryz, Alternaria alternala and Fusarium oxysporum, while benzoate is better against Aspergillus niger. Among diesters, malonate is more active against all the test fungi except F. oxysporum. Against A. alternata , coupling of monoterpenoid molecules through diester bridge containing one methylene group (malonate) is more active. Among simple ethers and esters, respectively, menthyl benzyl ether and menthyl cinnamate reflects the highest activity against F. oxysporum.</span

An Improved and Scalable Synthesis of Insensitive High Explosive 4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX)

4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX), a well-known nitramine category explosive, is much less sensitive to impact and friction stimuli as compared to the familiar explosives, RDX and HMX. TEX is currently produced on pilot plant scale and is being pursued as an insensitive explosive. Herein a newer, improved, efficient, and high yielding protocol is developed for the synthesis of TEX by using solid acidic silica sulfuric acid as an efficient and recyclable catalyst. Sequentially for process parameters optimization, a study was carried out with variation of catalyst loading, nitric acid, and mole ratio of reactants. The process scale-up is also achieved successfully

Novel Polyurea Microcapsules Using Dendritic Functional Monomer: Synthesis, Characterization, and Its Use in Self-healing and Anticorrosive Polyurethane Coatings

Polyamidoamine (PAMAM) dendrimer of zero generation was synthesized and characterized by Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopic techniques. A novel chemistry has been developed to synthesize polyurea microcapsules containing solvent and linseed oil as the active healing agent by interfacial polymerization of commercial methylene diphenyl diisocyanate (MDI) and dendritic 0.0 G PAMAM capable of cross-linking to form a shell material. Spherical with some irregular shape microcapsules were observed with average diameter from 20 to 270 μm at different agitation rates (3000–8000 rpm). Interfacial interaction between polyurea microcapsules and polyurethane (PU) coating were studied by FTIR, and this showed that chemical bonds were formed by the reaction between isocyanates and the amine groups present on the wall of microcapsules. The thermal stability of the microcapsules showed that prepared microcapsules experienced excellent stability up to 380 °C. The anticorrosive performance of PU coatingd loaded with different percentages of microcapsules was carried out in 5% NaCl aqueous solution. The results showed that the composite provides satisfactory anticorrosive properties at 5% capsule loading under an accelerated corrosion process. The idea and approach presented in this work have the potential to fabricate microcapsules which could provide better anticorrosive and mechanical properties to coating composites

Novel Polyurea Microcapsules Using Dendritic Functional Monomer: Synthesis, Characterization, and Its Use in Self-healing and Anticorrosive Polyurethane Coatings

Polyamidoamine (PAMAM) dendrimer of zero generation was synthesized and characterized by Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopic techniques. A novel chemistry has been developed to synthesize polyurea microcapsules containing solvent and linseed oil as the active healing agent by interfacial polymerization of commercial methylene diphenyl diisocyanate (MDI) and dendritic 0.0 G PAMAM capable of cross-linking to form a shell material. Spherical with some irregular shape microcapsules were observed with average diameter from 20 to 270 μm at different agitation rates (3000–8000 rpm). Interfacial interaction between polyurea microcapsules and polyurethane (PU) coating were studied by FTIR, and this showed that chemical bonds were formed by the reaction between isocyanates and the amine groups present on the wall of microcapsules. The thermal stability of the microcapsules showed that prepared microcapsules experienced excellent stability up to 380 °C. The anticorrosive performance of PU coatingd loaded with different percentages of microcapsules was carried out in 5% NaCl aqueous solution. The results showed that the composite provides satisfactory anticorrosive properties at 5% capsule loading under an accelerated corrosion process. The idea and approach presented in this work have the potential to fabricate microcapsules which could provide better anticorrosive and mechanical properties to coating composites