Penerapan Model Pembelajaran Kooperatif Tipe Think Pair Share (Tps) Untuk Meningkatkan Hasil Belajar IPA Siswa Kelas IV Sdn 24 Kuala Penaso Kecamatan Pinggir

This research aims to improve the learning process and improve learning outcomes sains of fourth grade students of SDN 24 Kuala Penaso Kecamatan Pinggir by implementing cooperative learning model Think Pair Share (TPS). The research subjects were fourth grade students who have the heterogeneous academic ability. This research is a class act with two cycles. Each cycle consisted of two meetings learning process and one-time Daily Deuteronomy (UH) which was held at the end of each cycle. This study also consists of four stages, namely planning, implementation, observation and reflection. This research presents the results obtained each before the implementation an improve in base score sycle with the average being 65, In the first cycle improve an average of 75,31 with increase as 15.86% and an impove in the second with an average of 84,69 with increase as 30,29%. The results of this study indicate that the implementing of cooperative learning model TPS can improve the process of learning sains and improve learning outcomes of fourth grade students of SDN 24 Kuala Penaso Kecamatan Pinggir of the full semester of the academic year 2015/2016

Upaya Peningkatan Hasil Belajar Matematika melalui Model Pembelajaran Kooperatif Tipe Team Assisted Individualization (Tai) Siswa Kelas Va SD Negeri 27 Negeri Sebangar Kecamatan Mandau Kabupaten Bengkalis

This research was conducted because of the result of learning Mathematic class VA SD Negeri 27 Sebangar. From 18 student who achieve KKM just 8 student (44,44%) while student who did'nt complete 11 student (55,56 %) with an average of 55,83. This research aims to increase learn result mathematic year school 2015-2016. This reaserch subject are student class V SD Negeri 27 Sebangar Kecamatan Mandau kabupaten Bengkalis. This matter can prove with the acquisition score teacher activity experience increase one cycle first appointment teacher activity presentation are 62,5% with the good caregory grow up to 12,5% to 75% with the good category. And than 2 cycle on the first appointment increase again 8,3% to 88,3 with the excellent category and the second appointment increase again 8,4% to 91,7%with the excellent category. So do with the student activity one cycle first appointment student presentation are 54,2% with the enough category grow up 8,3 to 62,5 with the good category. On the second appointment and than 2 cycle first appointment 12,5% to 75% with the excellent category the second appointment increase again 12,5% to 87,5% with the excellent category. With the increased teacher and student activity each appointment positive effect to increased study result student. It can see from the acquisition average basic 56,88 increase to daily exam one cycle average 88,05 and can increase again daily II, 2 cycle average 89,53. Therefore can conculuded that hypothesis in this research can applied to leaning model cooperative type TAI can increased study result Mathematic student class V SD Negeri 27 Sebangar Kecamatan Mandau Kabupaten Bengkalis

Penerapan Model Pembelajaran Berbasis Masalah untuk Meningkatkan Hasil Belajar Matematika Siswa Kelas Ivd SD Negeri 59 Boncah Mahang

This study was carried out because of low learning outcomes Mathematics fourth grade students of SD Negeri 59 Boncah Mahang. Of the 32 students who achieve KKM many as 17 people (53.12%) while students who did not complete (46.87%) with an average of 59.06. the purpose of this research is to improve learning outcomes Mathematical IVD grade students of SD Negeri 59 Boncah Mahang denganp Problem Based Learning model. The results of this study showed the average value of 59.06 Basic Scores increased in the first cycle of 3.70% to 61.25. the second cycle of the average value of students also increased by 26.35% to 74.62% on a base score completeness result of learning mathematics students only 53.12% (Action Completed) after application of the model teacher PBM in the first cycle classical completeness obtained are increased to increase to 74.62% , Activity Cycle I teacher at the first meeting of 74.37% with both categories. The second meeting increased to 80% in both categories. At the first meeting of the second cycle at 85% with the category very well, at the second meeting increased to 90% with very good category. Activities of students in the first cycle of the first meeting obtain sufficient percentage of 60% category. The second meeting 75% with very good category. In the second cycle at the first meeting of student activity increased to 80% with very good category. And at the second meeting increased to 85% with very good category

Penerapan Model Pembelajaran Berdasarkan Masalah untuk Meningkatkan Hasil Belajar IPA Siswa Kelas V SD Negeri 8 Duri Barat Kecamatan Mandau Kabupaten Bengkalis

This research was carried out because of low learning value of fifth grader students in Science subject of SD Negeri 8 Duri Barat District of Mandau Kabupaten Bengkalis . Among 20 Students, 7 students (35%) reached the standard of completeness while the students could not reach the standard is 13 students ( 35%) with average 58,5. The purpose of this study is to increase the fifth grader students' value in Science subject of SD Negeri 8 Duri Barat Kabupaten Bengkalis with the application of Problem Based Learning. The results obtained by the average value of the basic score of 58.5 in the first cycle increased by 10.5% to 69. In the second cycle the average value of students also increased as much as 23.25% to 92.25. On the basis of completeness score of Science, student learning outcomes is only 35% (not complete). After the teacher was applying the Problem Based Learning in the first cycle the classical completeness increase becoming 50 % ( not complete), In the second cycle the classical completeness also increased becoming 95%. Teacher's activity at the first meeting is 60% in enough category level. The second meeting increased becoming 75% in good category level. In the second cycle increased up to 85% in very good category level. In the second meeting of second cycle, the student's activity increased becoming 100% in the very good category level. The students' activity in the cycle I of first meeting got 55% percentage in enough category level. The second meeting of the first cycle to 65% in good category. At the first meeting of the second cycle of student activity increased to 75% in good category, and the second meeting of the second cycle increased again to 100% with a very good category

Spatial assessment on ambient air quality status: a case study in Klang, Selangor

Klang as the center of economic and industrial zone in Malaysia has been exposed to poor air quality condition over the years. This study was conducted to evaluate the spatial variation pattern of air quality status in Klang, Selangor by using a four years (2010-2013) secondary database from the Malaysian Department of Environment (DOE). The finding shows that carbon monoxide (CO) had a strong correlation with nitrogen dioxide (NO2) (r = 0.76, p < 0.001), while Air Pollutant Index (API) had moderate correlation with particulate matter (PM10) (r = 0.64, p < 0.001). Principal Component Analysis (PCA) indicates that the most significant air pollutants were NO2, CO and PM10. Statistical Process Control (SPC) reveals that several PM10 data beyond the limitations of SPC and the national guidelines. This study shows that active collaboration among all relevant environmental departments and agencies should be implemented for the effective management of air quality.Keywords: air quality; correlation; principal component analysis; statistical process control

Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells

The major impediment to effective cancer therapy has been the development of drug resistance. The tumour suppressive transcription factor FOXO3 promotes cell cycle arrest, senescence and cell death, and mediates the cytotoxic and cytostatic functions of cancer therapeutics. In consequence, FOXO3 is often downregulated as an adaptive response in cancer and particularly in chemotherapeutic drug-resistant cells. Consistently, we find that FOXO3 expression is attenuated in the drug-resistant MCF-7-EpiR and MCF-7-TaxR compared to the parental MCF-7 breast cancer cells. Using ChIP, short-interfering RNA (siRNA) knockdown, and overexpression assays as well as Foxo1/3/4−/− MEFs, we establish the endoplasmic reticulum (ER)-stress defence modulator PERK (eIF2AK3) as a direct downstream transcriptional target of FOXO3. In agreement, there is also a positive correlation between FOXO3 and PERK expression at the protein and RNA levels in breast cancer patient samples. We uncover that PERK expression is downregulated but its activity constitutively elevated in the drug-resistant cells. With this in mind, we exploit this adaptive response of low FOXO3 and PERK expression, and high PERK activity in drug-resistant breast cancer cells and show that these drug-resistant cells are specifically sensitive to PERK inhibition. In support of this finding, we show that ectopic overexpression of FOXO3 can reduce the sensitivity of the resistant cells to the PERK inhibitor GSK2606414, while the Foxo1/3/4−/− MEFs expressing lower levels of PERK are more sensitive to PERK inhibition compared to wild-type MEFs. PERK inhibitor-titration and -time course experiments showed that the drug-resistant cells, which express lower expression and higher activity levels of PERK, are more sensitive to the increasing concentrations of PERK inhibitor compared to parental MCF-7 cells. Our present work thus reveals a chemotherapeutic drug-resistant cancer cell vulnerability in PERK and suggests PERK as a potential target for cancer therapy, specifically in the context of drug-resistant cancers

Characterization of FOXO acetylation

FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes. Its inactivation is closely associated with tumorigenesis and cancer progression. On the other hand, sirtuin proteins have been demonstrated to be able to deacetylate, thus causing FOXO3 inactivation at the posttranslational level. Therefore, targeting sirtuin proteins renders new avenues for breast cancer treatment. Here, we describe three procedures for studying FOXO3 posttranslational modifications controlled by sirtuin proteins in cancer cells