228 research outputs found

    Globalisation as a legal problematic: balancing legal efficiency against legal principle: the case of money laundering

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    PhdOver the relatively short period of the last three decades, an extensive body of law, both penal and regulatory, has developed in order to prevent and to control th1s seemingly burgeoning phenomenon of money laundering. Initial examination of this body of law immediately reveals that it is a legal order that pushes against the traditional frameworks of criminal justice. For example, this new legal order persistently rings "alarm bells" regarding its compatibility with such fundamental principles as the presumption of innocence, the principle of legality, the immunity against double jeopardy, and the rights to privacy especially financial privacy. It also blurs the public nature of policing, the prosecutorial burden of proof and the jurisdictional territoriality of criminal law. Its formation at the international level shows strong signs of supranationalism that challenges State sovereignty and the principle of consent in international law. This tension between money laundering law and traditional legal principles poses two related questions: (1) What is the reason for this apparent exceptionality of money laundering law?; and (2) How could the tension between law and principle be resolved? As conventional wisdom has it, understanding the law can-not be disassociated from its social context. Certainly, understanding money laundering law is only possible through an understanding of the process of social change that shaped it. During these past three decades "globalisation" characterised the process of social change that has been gathering momentum. It is this context that has instigated and shaped money laundering law. Globalisation has been propelled by both rapid technological innovation that rendered massive instantaneous communication possible as well as extensive processes of de-regulation and liberalisation. The combined effect of these developments was the emergence of non-state actors that operate across national borders and master substantial economic and informational power. Meanwhile, the State, as the primary agency of governance, has remained jurisdictionally territorial while becoming less dominantly powerful. Both features have resulted in a "governance crisis" and has turned globalisation into a "legal problematic. " The core thesis that emerges from this contextual analysis is that money laundering law is a response to globalisation as a legal problematic. As a solution, it employs six modalities of governance: de- glob alisation, extraterritorialisation, harmonisation, co-operation, privatisation and supranatinl-ql--,] -iq---ti,o, n, which are characterised by deviation from traditional legal principles. In terms of its modalities and their characteristics, money laundering law is not a unique response to the legal problematic. It is part of a current and general trend in legal governance. Resolving the tension between this trend and traditional legal principles is a two-way process that involves revising both the law and the principles. In presenting this thesis, the volume will be organised into seven chapters. Following ail introductory Chapter, Chapters Two and Three will analyse the legislative policy underlying money laundering law by conducting contextual and historical analysis. Chapters Four, Five and Six will expound upon the six modalities utilised by money laundering law to address the governance problem posed by globalisation. Finally, Chapter Seven will sum up the argument and suggest some direction for the future

    Study the Inhibition Effect of Amoxicillin Drug for Corrosion of Carbon Steel in Saline Media

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              تم استخدام طرق الاستقطاب المجهادي الساكن وفقدان الوزن لدراسة سلوك تآكل الفولاذ الكربوني في محلول كلوريد الصوديوم بتراكيز مختلفة (0.1 و 0.4 و 0.6) مولاري تحت تأثير درجات الحرارة (293 و 298 و 303 و 308 و 313) كلفن. كذلك تم دراسة كفاءة تثبيط دواء الأموكسيسيلين على تآكل  الفولاذ الكربوني في  محلول كلوريد الصوديوم بتركيز 0,6 مولاري على أساس التركيز ودرجة الحرارة. أظهرت النتائج المستحصل عليها  ان كل تراكيز الملح (محلول كلوريد الصوديوم) أدت إلى   تآكل الفولاذ الكربوني بنسب متفاوتة وكان معدل التآكل عند تركيز 0.6 مولاري من محلول الملح هو الاعلى (50.46 جم / م 2 د). تشير النتائج أيضًا إلى أن معدل التآكل لكل تراكيز الملح  يزداد عند درجة حرارة 313 كلفن. أظهرت دراسات الاستقطاب المجهادي أن المثبط يقلل كل من العمليات الأنودية و الكاثودية ويتصرف كمثبط من النوع المختلط. وجد ان  امتزاز ألاموكسيسيلين يخضع لنموذج  لانكماير متساوي الحرارة. تم استخدام معادلة ارينيوس ونظرية الحالة الانتقالية لحساب  المعاملات الحركية والديناميكية الحرارية. أظهرت النتائج التي تم الحصول عليها أن تفاعل تآكل الفولاذ الكربوني في كلوريد الصوديوم هو تلقائي وهناك اتفاق جيد بين النتائج التي تم الحصول عليها من كلتا التقنيتين المستخدمتين. تم إجراء تحليلات بالمجهر الالكتروني الماسح ((SEM لدراسة ثبات الطبقة الواقية للمثبط.          Potentiostatic polarization and weight loss methods have been used to investigate the corrosion behavior of carbon steel in sodium chloride solution at different concentrations (0.1, 0.4 and 0.6) M under the influence of temperatures ( 293, 298, 303, 308 and 313) K. The inhibition efficiency of the amoxicillin drug on carbon steel in 0.6 M NaCl has also been studied based on concentration and temperature. The corrosion rate showed that all salt concentrations ( NaCl solution) resulted in corrosion of carbon steel in varying ratio and 0.6 M of salt solution  was the highest rate (50.46 g/m².d). The results also indicate that the rate of corrosion increases at a temperature of 313 K.. Potentiodynamic polarization studies showed that the examined inhibitor suppress both anodic and cathodic process and behave as mixed type inhibitor. The adsorption of amoxicillin was found to obey Langmuir isotherm model. Arrhenius equation and transition state theory were used to calculate kinetic and thermodynamic parameter. Results obtained showed that corrosion reaction of carbon steel in NaCl is spontaneous and there is a good agreement between the data got from the both techniques employed. SEM analysis was performed to study the film persistency of the inhibitor

    Ruling on Zakat on Digital Currencies Rooted in the Noble Qur'an and the Prophet's Sunnah

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    Praise be to God, Lord of the worlds, who guided us and brought us out of darkness into light, and prayers and peace be upon the messenger as a mercy to the worlds, who delivered the message and advised the nation, and all his family and companions. Digital currencies are one of the modern calamities that many people wonder about, some are confused about, and many wonder how to deal with them. Is it an illusion or reality? Most of the dealers of digital currencies wonder about its legal ruling and whether the provisions that apply to money issued by official state banks also apply to it. Therefore, the research aims to clarify the ruling on zakat on digital currencies from the perspective of the Noble Qur'an and the purified Sunnah of the Prophet. Keywords: digital currencies, zakat

    Comparison of Serum Zinc and Copper levels in Children and adolescents with Intractable and Controlled Epilepsy

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    How to Cite This Article: Kheradmand Z, Yarali B, Zare A, Pourpak Z, Shams S, Ashrafi MR. Comparison of Serum Zinc and Copper levels in Children and adolescents with Intractable and Controlled Epilepsy. Iran J Child Neurol. 2014; 8(3):49-54. AbstractObjectiveTrace elements such as zinc and copper have physiological effects on neuronal excitability that may play a role in the etiology of intractable epilepsy. This topic has been rarely discussed in Iranian epileptic patients.This study with the analysis of serum zinc and copper levels of children and adolescents with intractable and controlled epilepsy may identifies the potential role of these two trace elements in the development of epilepsy and intractabilityto antiepileptic drug treatment. Materials & MethodsSeventy patients between the ages of 6 months to 15 years that referred to Children’s Medical Center with the diagnosis of epilepsy, either controlled or intractable to treatment enrolled in the study. After informed parental consent the levels of serum zinc and copper were measured with atomic absorptionspectrophotometer and analyzed with SPSS version 11.Results35 patients were enrolled in each group of intractable (IE) and controlled epilepsy (CE). 71.45% of the IE and 25.72% of the CE group had zinc deficiency that was statistically significant. 48.58% of the IE and 45.72 of the CE group were copper deficient, which was not statistically significant.ConclusionOur findings showed significant low serum zinc levels of patients with intractable epilepsy in comparison with controlled epilepsy group. We recommend that serum zinc level may play a role in the etiology of epilepsy and intractable epilepsy therefore its measurement and prescription may be regarded in the treatment of intractable epilepsy.ReferencesMikati MA. Seizures in childhood. In: Kliegman RM, Stanton BF, Schor NF, Geme JWS, Behrman R (eds). Nelson textbook of pediatrics. 19th ed. Elsevier:Saunders; 2011. Pp.2013-2033.Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342: 314-9.Patrick Kwan, Alexis Arzimanoglou, Anne T. Berg, et al.  Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010;51(6):1069-1077.Berg AT, Shinnar S, Levy SR, Testa F, Smith-Rapaport S, Beckerman B. Early development of intractableepilepsy in children: a prospective study. Neurology 2001;56:1445-1452.Haoa XT, Wong ISM, Kwan P. Interrater reliability of the international consensus definition of drug-resistant epilepsy: A pilot study. Epilepsy & Behavior 2011;22;388-390. Ashrafi MR, Mohseni M, Shams S, Shabanian R, Yekaninejad MS, et al. A Probable Causative Factor for an Old Problem: Selenium and Glutathione Peroxidase Appear to Play Important Roles in Epilepsy pathogenesis. Epilepsia 2007;48(9):1750-1755.Liochev SI, Fridovich, I. Copper- and zinc-containing superoxide dismutase can act as a superoxide reductase and a superoxide oxidase. J Biol Chem 2000; 275: 38482-38485.Jacob RA. Trace Elements in textbook of Clinical Chemistry. WB Saunders, 1986. pp. 965-985.Salwen MJ. Vitamis and Trace Elements. In: Pherson RA, Pincus MR (eds). Henry’s Clinical Diagnosis and Management By Laboratory Methods Tweny-First Edition. Saunders; 2007. Pp. 379-389.Rokgauerj M, Klein J Kruse-Jarres J. D. Reference Values for the Trace Elements Copper, Manganese, Selenium, and Zinc in the Serum/ Plasma of Children, Adolescents, and Adults. J Trace Element Med Biol. 1997;11: 92-98.Volpe SL, Schall JI, Gallagher PR, Stallings VA, Bergqvist AGC. Nutrient intake of children with intractable epilepsy compared with healthy children. Journal of the American Dietetic Association 2007;107(6):1014-8. Epub 2007/05/26.Wojciak RW, Mojs E, Stanislawska-Kubiak M, Samborski W. The serum zinc, copper, iron, and chromium concentrations in epileptic children. Epilepsy Research 2013;104:40-44.Hamed SA, Abdellah MM, El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stress/antioxidant systems in epileptic patients. J Pharmacol Sci 2004;96:465-473.Dudek FE. Zinc and epileptogenesis. Epilepsy Curr 2001; 1:66-70.Mathie A, Sutton GL, Clarke CE, Veale EL. Zinc and copper: pharmacological probes and endogenous  modulators of neuronal excitability. Pharmacol Ther. 2006;111(3):567-83. Epub 2006/01/18.Schrauzer GN. Selenomethionine and Selenium Yeast: Appropriate Forms of Selenium for Use in Infant Formulas and Nutritional Supplements. Journal of medicinal food 1998;1(3):201-6.Seven M, Basaran SY, Cengiz M, Unal S. Deficiency of selenium and zinc as a causative factor For idiopathic intractable epilepsy. Epilepsy Research 2013;104 :35-39

    The Status of Natural Radioactivity and Heavy Metals Pollution on Marine Sediments Red Sea Coast, At Safaga, Egypt

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    Natural 226Ra, 232Th and 40K radio nuclides concentration in beach Sediments along Safaga coast of Red sea, Egypt has been carried out using a NaI (Tl) gamma ray spectrometric technique. The total average concentrations of radionuclides ± uncertainty of 226Ra, 232Th and 40K were 22.2 ± 1.7, 19.2 ± 2.5, and 477.6 ± 27.6 Bqkg-1, respectively. The total average absorbed dose rate is found to be 41.4 nGyh-1, whereas the annual effective dose rate has an average value of 54 μSvy-1. The total organic matter (TOC), carbonates (CaCo3) and Heavy metals distribution have been measured at some locations, the concentration for the investigated heavy metals overtake the allowable limits recommended by the Canadian Environmental Quality Guidelines, this assigned to the ratio of metals pollution is caused by anthropogenic activities (phosphate shipment as in Abu Tartour harbor and navigation as in Touristic harbor) and or by natural impacts such in mangrove interment. Statistical analyses were carried out between the parameters obtained from the radioactivity to know the existing relations and to study the spatial distribution of radionuclide

    Immunological Markers in Children with Genetic Disorders and Recurrent Respiratory Tract Infections

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    BACKGROUND: Recurrent respiratory tract infections (RRI) are one of the extremely high common reasons for pediatric visits and hospitalization. Immunodeficiencies are considered as important conditions that may increase the probability of occurrence of RRI. Mannose-binding lectin (MBL2) is a protein of the innate immune system involved in the opsonization and the complement activation. MBL2 deficiency is associated with infectious diseases mainly chest infections; however, subnormal MBL2 levels are also seen in healthy subjects. Primary immunedeficiencies are associated with recurrent infections which mainly appear in early childhood. AIM: The aim of the study was to estimate T and B and natural killer cells percentage and to investigate the MBL2 and immunoglobulins (Igs) serum levels in children with recurrent RRIs in different genetic disorders compared to normal control. METHODS: This study included 50 children having a history of recurrent RRIs. All patients had genetic disorders and referred to National Research Centre for follow-up, in addition to, 25 children, age- and sex-matched as a healthy control group. They were subjected to full clinical examination and laboratory investigations including complete blood count (CBC), CD3, CD4, CD8, CD16, and CD19 by flow cytometry, MBL2 by enzyme-linked immunosorbent assay (ELISA), and Igs serum concentrations by nephelometry. RESULTS: CD16 showed a non-statistical significant difference between both patient groups. Serum levels of IgA in patient groups showed a significant decrease compared to the control group. Moreover, the serum level of IgM results shows a highly significant decrease when compared with the control group. There was no statistically significant difference in MBL2 and IgG serum levels between patient groups and control group. CONCLUSION: Children with genetic disorders and recurrent RRIs showed a statistically significant decrease of IgA and IgM serum levels as compared to the control group, while the serum level of MBL2 did not show significant results

    Immunophenotyping of chronic B-cell neoplasms: flow cytometry versus immunohistochemistry

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    Morphological differentiation between benign and malignant lymphoproliferative disorders (LPDs) can be challenging. Immunophenotyping (IPT) by either technique, flow cytometry or immunohistochemistry (IHC), is an important step in solving such difficulty. Thirty-five newly diagnosed patients with chronic B-cell neoplasms (11 chronic lymphocytic leukemia, 22 non Hodgkin lymphoma and 2 hairy cell leukemia) were included in this study with age range from 20 to 70 years. Monoclonal antibodies surface expression using lymphoproliferative disorders panel (CD45, CD19, CD5, CD10, CD11c, CD20, CD22, CD23, CD38, CD79b, FMC7, CD103, CD25, kappa and lambda light chains) by flow cytometry was done on bone marrow samples. CD20, CD5, CD23, Bcl-2, Bcl-6, kappa and lambda light chain immunostaining were performed on fixed bone marrow trephine biopsy specimen. The sensitivity of IHC was 81.8% in chronic lymphocytic leukemia (CLL) and 100% in non Hodgkin lymphoma (NHL) as regards CD20, 100% in both groups as regards CD5, 46% in CLL and 66.7% in NHL as regards CD23, 33.3% in CLL and 50% in NHL as regards kappa chain, 20% in CLL and 33.3% in NHL as regards lambda chain. We found that IHC and flow cytometry are equally effective in diagnosing CLL; however, IHC might be slightly more sensitive than flow cytometry in detecting bone marrow infiltration in NHL and hairy cell leukemia (HCL)

    The effect of using software on the production processes of smart factory ceramic tiles case study

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    The research discussed the impact of applying some concepts in engineering and design of scheduling tool and modeling software, in solving general ceramic tile production problems, especially in smart factory process systems, by making use of software volume and scheduling models. We hope to expand its application and implementation in the ceramic industry sector in Egypt, and to spread the experience of its applications. Presenting a model of the production process, then describing in detail the great development in the systems of smart ceramic tile production processes as a case study for one of the international companies in the industry and the ceramic sector. We focus on development in the ceramic tiles sector by making use of developed scheduling systems, to model problems to find solutions digitally using computer programs. The research clarified the importance of applying software and manufacturing scheduling systems to improve the quality of the ceramic product with the provision of scheduling models, and a case study of a smart factory for ceramic production that uses the digital approach and applies smart programs on all its lines to produce ceramic tiles with all variables. The research dealt with Industry 4.0 and its most important characteristics and benefits for making improvements in the industrial process, and managing the product life cycle in smart factories through a smart powder factory for the ceramic body and innovations designed to improve process efficiency and a smart production line that ensures formation, drying, decoration and fire lines for ceramic tiles and plates in the best possible conditions to achieve the highest levels possible Quality, Productivity and Operational Flexibility The innovative large hydraulic presses, combined with Deep Digital decoration technology, are state of the art in the industry. The new thermal machines (dryers and ovens) guarantee high quality standards and at the same time, reduce energy consumption and environmental impact. And smart warehousing allows production to be organized in batches, facilitating product changeover and increasing the efficiency of ceramic production, depending on the work order. Offers a wide range of tile and large slab sorting and packing machines as well as smart supply chains
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