Comparative Study on Serum Enzyme Levels in Cirrhosis of Liver and Alcoholic Liver Disease

Patients with chronic liver diseases are asymptomatic or have only vague non-specific symptoms. Effective medical treatments for chronic liver disease (before cirrhosis is established) are becoming increasingly available and since abnormal LFTs may be the only indication of this diseases. Aims: comparative study on serum Enzyme levels in various liver diseases. Discussion: serum Alkaline phosphatase(ALP), Gamma Glutamyl transferase (Gamma GT), Alanine and Aspartate amino transferases were estimated in viral Hepatitis, Alcoholic liver diseases, Obstructive jaundice, cirrhosis of the liver. It was observed that obstructive jaundice shows higher levels of ALP levels followed by alcoholic liver disease, viral hepatitis, cirrhosis of liver. Viral hepatitis shows higher rise of SGOT, SGPT levels, followed by alcoholic liver disease, obstructive jaundice, and cirrhosis of liver. Gamma Glutamyl transferase enzymes highest levels are seen in alcoholic liver disease. Conclusion: These enzymatic variations are useful to diagnose the disease and classify them according to etiology

To study the organization of LDL-C/HDL-C ratio and inflammatory marker CRP in acute myocardial infarction

There is an increasing incidence of coronary artery disease in India. We therefore need a tool to evaluate the severity and prognosis of this acute myocardial infarction. In acute myocardial infarction, the function of plaque rupture and inflammation has already been identified. Aim: To study the organization of LDL-C/HDL-C ratio and inflammatory marker CRP in acute myocardial infarction. Methods and Material: Patients who have been diagnosed as acute myocardial infarction (ST Elevation Acute myocardial Infarction or Unstable angina/Non ST Elevation Myocardial Infarction) and admitted to ICCU of Rajiv Gandhi institute of Medical Sciences, Kadapa, AP. are the subjects. Sample consists of 100 cases of acute myocardial infarction. Case history was taken from the patients, and studied according to proforma. Conclusion: Elevated levels of CRP are independent indicators of adverse effects. When contrast with the LDL / HDL ratio, CRP is used for risk stratification and as a prognostic predictor. These findings suggest that in patients with acute myocardial infarction, raised CRP Levels is significant as compared to LDL/HDL ratio

A Comparative study of oxidant and Anti-oxidant parameters in Chronic Renal Failure, Haemodialysis (Pre &Post) and Controls

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Aim of our study is comparison of oxidant and anti oxidant parameters in chronic renal failure, Hemodialysis (pre and post) and control subjects. Materials and Methods: The present study was conducted on a patient group comprising of 50 patients diagnosed with CRF, 50 were pre hemodialysis, 50 were post hemodialysis (MHD). This patient group was compared to a healthy group including 100 controls. All the study participants were admitted in the department of Medicine [Nephrology department] at “Fathima Institute of Medical Sciences”, Kadapa. Andhra Pradesh. India. The obtained serum samples were used for biochemical analysis for estimating MDA, vitamin A and Glutathione Peroxidase (GPx). Conclusion: Our results reflects the primary mechanisms of oxidative stress and inflammation during hemodialysis which may cause of CVD development in hemodialysed patients

To analyze how LDL-C/HDL-C ratio and inflammatory marker CRP are organized in acute myocardial infarction

There is an increasing incidence of coronary artery disease in India. We therefore need a tool to evaluate the severity and prognosis of this acute myocardial infarction. In acute myocardial infarction, the function of plaque rupture and inflammation has already been identified. Aim: To study the organization of LDL-C/HDL-C ratio and inflammatory marker CRP in acute myocardial infarction. Methods and Material: Patients  who  have  been  diagnosed  as  acute  myocardial  infarction (ST Elevation  Acute  myocardial  Infarction  or  Unstable  angina/Non  ST  Elevation Myocardial Infarction) and admitted to ICCU of Government of medical sciences, Kadapa, AP. July 2021 to December 2021, are the subjects. Sample consists of 100 cases of acute myocardial infarction. Case history was taken from the patients, and studied according to proforma. Conclusion: Elevated levels of CRP are independent indicators of adverse effects. When contrast with the LDL / HDL ratio, CRP is used for risk stratification and as a prognostic predictor. These findings suggest that in patients with acute myocardial infarction, raised CRP Levels is significant as compared to LDL/HDL ratio

A comparative study of oxidant and anti-oxidant parameters in chronic renal failure, haemodialysis (pre & post) and controls

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Aim of our study is comparison of oxidant and anti oxidant parameters in chronic renal failure, Hemodialysis (pre and post) and control subjects. Materials and Methods: The present study was conducted on a patient group comprising of 50 patients diagnosed with CRF, 50 were pre hemodialysis, 50 were post hemodialysis (MHD). This patient group was compared to a healthy group including 100 controls. All the study participants were admitted in the department of Medicine [Nephrology department] at “Rajiv Gandhi Institute Of Medical Sciences”, Kadapa. Andhra Pradesh. India. Study Period : July 2020 to December 2020 ,The obtained serum samples were used for biochemical analysis for estimating MDA, vitamin A and Glutathione Peroxidase (GPx).&nbsp

To study an elderly people's abnormal electrocardiographic changes at government hospital

Population aging is one of the demographic characteristics of the 21st century. This process is necessarily accompanied by an increase in the prevalence of cardiovascular diseases that may have expression on the electrocardiogram (ECG). Aim: to study an elderly people's abnormal electrocardiograph at government hospital. Material and Methods:All the Patients were admitted in the department of Medicine at  Government medical college, Kadapa, Andhra Pradesh, India. Study period January 2021 to june 2021These participants were then clinically examined and studied in accordance with the study's guidelines to generate the necessary data, which was then categorised, tabulated, and classed before being subjected to analysis. Total 300 persons should taken in the study.150 were healthy one and 150 were patients. The age of the persons should be 65 years and above, both the sex were included. Conclusion: Atrial fibril-lation was the most prevalent rhythm abnormality. With no association to sex or skin tone, ventricular repolarization changes outweighed ventricular depolarization changes. There were a sizable number of instances with extended QT, left ventricular hypertrophy, and anomalous left atrium

A study of blood stream infesctions in intensive care units, government hospital, Ambikapur

Any bacterial cells found in the blood should raise concern because it is sterile. Bacteremia is the term used to describe the presence of live, transitory bacteria in the blood. However, in the majority of bacteremic conditions, only a tiny number of bacterial cells enter, and no symptoms appear because the transients are quickly eliminated. immune blood cells eliminate. Aim: a study of blood stream infesctions in intensive care units, government hospital,ambikapur. MATERIALS AND METHODS :The study was carried out in the department of microbiology, central laboratory RSDKSGMC and Hospital, Ambikapur, CG. STUDY PERIOD: Oct 2021 to Dec 2021.Total 150 Number of patients. The study was approved by the ethical committee of RSDKS GMC, Ambikapur, Surguja, C.G. with reference number 2388A/GMC/2021/06-04-2021. CONCLUSION: To enhance the clinical outcome of BSIs in the ICU setting, several techniques should be put into practise. An immediate start to an investigation is still crucial.effective antibiotic therapy that should be personalized. Depending on the source of the illness in each individual patient,the likelihood of antibiotic resistance as well as the most frequently isolated bacteria

Evaluate the liver injury in COVID-19 patients at government medical college and hospital, Ambikapur

A pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or novel coronavirus disease (COVID-19) began in December 2019 in China's Wuhan region and spread worldwide by April 2020, affecting 187 of the world's 192 countries with varied degrees of severity. When alanine aminotransferase (ALT) was > 55 U/l or total bilirubin was > 1.6 mg/dl, a patient was regarded to have liver damage. For laboratory data, the Spearman correlation coefficient was calculated, and bivariable analysis for mortality and/or the need for intensive care was performed. Aim: To evaluate the liver injury in covid-19  patients at government medical college and hospital. Methods and Materials: All the Patients were admitted in Covid ward at Govt. medical college and hospital, Ambikapur, Chhattisgarh. India. Present study were divided into two groups. Group-I: Female COVID Positive Patients -20, Group-II –Male COVID positive Patients -20.Conclusion: To summarise, patients with COVID-19 in Ambikapur, Chattisgarh, had a significant rate of abnormal liver function tests, which was linked to poorer outcomes when they developed severe acute respiratory distress syndrome

Bacteriological profile of osteomyelitis patients in government hospital, Ambikapur

Osteomyelitis is an infection and inflammation of the bone. Bacteria are the primary cause of osteomyelitis. Infections with fungi and viruses can also cause it.It usually affects children and others who are immunocompromised. Although bacteria cannot colonise bone ordinarily, events such as trauma, ischemia, surgery, the presence of foreign particles, or the insertion of prostheses can disrupt bone integration, eventually leading to infection.AIM :  To study Bacteriological profile of osteomyelitis patients in Government Hospital, Ambikapur. Material And Material: During the study period of April2021 to Oct 2021 for this study 30 patients who were diagnosed clinically and radiologically as a case of Chronic Osteomyelitis are participating  in this study. The risk factors for Chronic Osteomyelitis were obtained from patient case sheets with the help of orthopedic surgeons in the department of orthopedic RSDKSGMC and Hospital.In this study, the total number of cases Chronic Osteomyelitis considered was 30.with age group of 1-60 years and both the sexs. Conclusion: Chronic osteomyelitis is a chronic disease that affects the long bones, particularly the femur and tibia, and is most common in adults. Haematogenous Osteomyelitis is becoming less common as antibiotics become more widely available and children's growing bones have a higher vascular metaphysis.&nbsp