744 research outputs found
Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities. To get a better understanding of the cardiac cell cycle and its regulation, the effect of functional recovery of the mitosis-promoting factor (MPF) consisting of cyclin B1 and the cyclin-dependent kinase Cdc2 was assessed in primary cultures of postmitotic ventricular adult rat cardiomyocytes ( ARC). Gene transfer into ARC was achieved using the adenovirus-enhanced transferrinfection system that was characterized by the absence of cytotoxic events. Simultaneous ectopic expression of wild-type versions of cyclin B1 and Cdc2 was sufficient to induce MPF activity. Reestablished MPF resulted in a mitotic phenotype, marked by an abnormal condensation of the nuclei, histone H3 phosphorylation and variable degree of decay of the contractile apparatus. Although a complete cell division was not observed, the results provided conclusive evidence that cell cycle-related events in postmitotic cardiomyocytes could be triggered by genetic intervention downstream of the G1/S checkpoint. This will be of importance to design novel strategies to overcome the proliferation arrest in adult cardiomyocytes
Two-photon interference with two independent pseudo-thermal sources
The nature of two-photon interference is a subject that has aroused renewed
interest in recent years and is still under debate. In this paper we report the
first observation of two-photon interference with independent pseudo-thermal
sources in which sub-wavelength interference is observed. The phenomenon may be
described in terms of the classical statistical distribution of the two sources
and their optical transfer functions.Comment: Phys. Rev. A 74, 053807 (2006
Book reviews
Foods, nutrients and food ingredients with authorised EU health claims.
M.J. SADLER (Ed.).
Woodhead Publishing is an imprint of Elsevier, Cambridge, UK, Waltham, US, Kidlington, UK, Series in Food
Science, Technology and Nutrition: Number 263, 2014
ISBN 978-0-85709-842-9 (print), ISBN 978-0-85709-848-1 (e-book), 397 page
Semi-invariants of symmetric quivers of finite type
Let be a symmetric quiver, where is a finite
quiver without oriented cycles and is a contravariant involution on
. The involution allows us to define a nondegenerate bilinear
form on a representation $V$ of $Q$. We shall call the representation
orthogonal if is symmetric and symplectic if is skew-symmetric.
Moreover we can define an action of products of classical groups on the space
of orthogonal representations and on the space of symplectic representations.
For symmetric quivers of finite type, we prove that the rings of
semi-invariants for this action are spanned by the semi-invariants of
determinantal type and, in the case when matrix defining is
skew-symmetric, by the Pfaffians
Exact-exchange density-functional calculations for noble-gas solids
The electronic structure of noble-gas solids is calculated within density
functional theory's exact-exchange method (EXX) and compared with the results
from the local-density approximation (LDA). It is shown that the EXX method
does not reproduce the fundamental energy gaps as well as has been reported for
semiconductors. However, the EXX-Kohn-Sham energy gaps for these materials
reproduce about 80 % of the experimental optical gaps. The structural
properties of noble-gas solids are described by the EXX method as poorly as by
the LDA one. This is due to missing Van der Waals interactions in both, LDA and
EXX functionals.Comment: 4 Fig
Semi-invariants of symmetric quivers of tame type
A symmetric quiver is a finite quiver without oriented cycles
equipped with a contravariant involution on . The involution allows us to define a nondegenerate bilinear form on
a representation $V$ of $Q$. We shall say that $V$ is orthogonal if is
symmetric and symplectic if is skew-symmetric. Moreover, we define an
action of products of classical groups on the space of orthogonal
representations and on the space of symplectic representations. So we prove
that if is a symmetric quiver of tame type then the rings of
semi-invariants for this action are spanned by the semi-invariants of
determinantal type and, when matrix defining is skew-symmetric, by
the Pfaffians . To prove it, moreover, we describe the symplectic and
orthogonal generic decomposition of a symmetric dimension vector
Zero-one Schubert polynomials
We prove that if σ∈Sm is a pattern of w∈Sn, then we can express the Schubert polynomial w as a monomial times σ (in reindexed variables) plus a polynomial with nonnegative coefficients. This implies that the set of permutations whose Schubert polynomials have all their coefficients equal to either 0 or 1 is closed under pattern containment. Using Magyar's orthodontia, we characterize this class by a list of twelve avoided patterns. We also give other equivalent conditions on w being zero-one. In this case, the Schubert polynomial w is equal to the integer point transform of a generalized permutahedron
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