Relations among higher order values around the world

The circular structure of basic human values is the core element of the Schwartz value theory. The structure demonstrated high robustness across cultures. However, the specific correlations between values and the differences in these correlations across countries have received little attention. The current research investigated the within-country correlations between the four higher order values. We estimated the correlations with meta-analytical mixed-effects models based on 10 surveys, on different value instruments, and on data from 104 countries. Analyses revealed theoretically expected negative relations between openness to change and conservation values and between self-transcendence and self-enhancement values. More interestingly, openness to change and self-transcendence values related negatively with each other, as did conservation and self-enhancement. Openness to change and self-enhancement values related predominantly positively, as did conservation and self-transcendence values. Correlations between the adjacent values were weaker in more economically developed countries, revealing higher value complexity of these societies. These findings were consistent across multiple surveys and after controlling for levels of education and income inequality. We concluded that, across most countries, values tend to be organized predominantly in line with the Social versus Person Focus opposition, whereas the Growth versus Self-Protection opposition is pronounced only in more economically developed countries.info:eu-repo/semantics/acceptedVersio

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis (HC) is lacking. One of the obstacles to understanding the role of Shiga toxins to STEC-mediated intestinal pathology is a deficit in small animal models that perfectly mimic human disease. Infant rabbits have been previously used to study STEC and/or Shiga toxin-mediated intestinal inflammation and diarrhea. We demonstrate using infant rabbits that Shiga toxin-mediated intestinal damage requires A-subunit activity, and like the human colon, that of the infant rabbit expresses the Shiga toxin receptor Gb3. We also demonstrate that Shiga toxin treatment of the infant rabbit results in apoptosis and activation of p38 within colonic tissues. Finally we demonstrate that the infant rabbit model may be used to test candidate therapeutics against Shiga toxin-mediated intestinal damage. While the p38 inhibitor SB203580 and the ZAK inhibitor DHP-2 were ineffective at preventing Shiga toxin-mediated damage to the colon, pretreatment of infant rabbits with the drug imatinib resulted in a decrease of Shiga toxin-mediated heterophil infiltration of the colon. Therefore, we propose that this model may be useful in elucidating mechanisms by which Shiga toxins could contribute to intestinal damage in the human

1989 as a mimetic revolution: Russia and the challenge of post-communism

Various terms have been used to describe the momentous events of 1989, including Jürgen Habermas’s ‘rectifying revolution,’ and my own notion of 1989 as a type of ‘anti-revolution’: repudiating not only what had come before, but also denying the political logic of communist power, as well as the emancipatory potential of revolutionary socialism in its entirety. In the event, while the negative agenda of 1989 has been fulfilled, it failed in the end to transcend the political logic of the systems that collapsed at that time. This paper explores the unfulfilled potential of 1989. Finally, 1989 became more of a counter- rather than an anti-revolution, replicating in an inverted form the practices of the mature state socialist regimes. The paucity of institutional and intellectual innovation arising from 1989 is striking. The dominant motif was ‘returnism,’ the attempt to join an established enterprise rather than transforming it. Thus, 1989 can be seen as mimetic revolution, in the sense that it emulated systems that were not organically developed in the societies in which they were implanted. For Eastern Europe ‘returning’ to Europe appeared natural, but for Russia the civilizational challenge of post-communism was of an entirely different order. There could be no return, and instead of a linear transition outlined by the classic transitological literature, Russia’s post-communism demonstrated that the history of others could not be mechanically transplanted from one society to another

A Concerted Kinase Interplay Identifies PPARγ as a Molecular Target of Ghrelin Signaling in Macrophages

The peroxisome proliferator-activator receptor PPARγ plays an essential role in vascular biology, modulating macrophage function and atherosclerosis progression. Recently, we have described the beneficial effect of combined activation of the ghrelin/GHS-R1a receptor and the scavenger receptor CD36 to induce macrophage cholesterol release through transcriptional activation of PPARγ. Although the interplay between CD36 and PPARγ in atherogenesis is well recognized, the contribution of the ghrelin receptor to regulate PPARγ remains unknown. Here, we demonstrate that ghrelin triggers PPARγ activation through a concerted signaling cascade involving Erk1/2 and Akt kinases, resulting in enhanced expression of downstream effectors LXRα and ABC sterol transporters in human macrophages. These effects were associated with enhanced PPARγ phosphorylation independently of the inhibitory conserved serine-84. Src tyrosine kinase Fyn was identified as being recruited to GHS-R1a in response to ghrelin, but failure of activated Fyn to enhance PPARγ Ser-84 specific phosphorylation relied on the concomitant recruitment of docking protein Dok-1, which prevented optimal activation of the Erk1/2 pathway. Also, substitution of Ser-84 preserved the ghrelin-induced PPARγ activity and responsiveness to Src inhibition, supporting a mechanism independent of Ser-84 in PPARγ response to ghrelin. Consistent with this, we found that ghrelin promoted the PI3-K/Akt pathway in a Gαq-dependent manner, resulting in Akt recruitment to PPARγ, enhanced PPARγ phosphorylation and activation independently of Ser-84, and increased expression of LXRα and ABCA1/G1. Collectively, these results illustrate a complex interplay involving Fyn/Dok-1/Erk and Gαq/PI3-K/Akt pathways to transduce in a concerted manner responsiveness of PPARγ to ghrelin in macrophages

Suppression of Ribosomal Function Triggers Innate Immune Signaling through Activation of the NLRP3 Inflammasome

Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium. Loss of cellular potassium is known to potently suppress protein synthesis, leading us to test whether the inhibition of protein synthesis itself serves as an activating signal for the NLRP3 inflammasome. Murine bone marrow-derived macrophages, either primed by LPS or unprimed, were exposed to a panel of inhibitors of ribosomal function: ricin, cycloheximide, puromycin, pactamycin, and anisomycin. Macrophages were also exposed to nigericin, ATP, monosodium urate (MSU), and poly I:C. Synthesis of pro-IL-ß and release of IL-1ß from cells in response to these agents was detected by immunoblotting and ELISA. Release of intracellular potassium was measured by mass spectrometry. Inhibition of translation by each of the tested translation inhibitors led to processing of IL-1ß, which was released from cells. Processing and release of IL-1ß was reduced or absent from cells deficient in NLRP3, ASC, or caspase-1, demonstrating the role of the NLRP3 inflammasome. Despite the inability of these inhibitors to trigger efflux of intracellular potassium, the addition of high extracellular potassium suppressed activation of the NLRP3 inflammasome. MSU and double-stranded RNA, which are known to activate the NLRP3 inflammasome, also substantially inhibited protein translation, supporting a close association between inhibition of translation and inflammasome activation. These data demonstrate that translational inhibition itself constitutes a heretofore-unrecognized mechanism underlying IL-1ß dependent inflammatory signaling and that other physical, chemical, or pathogen-associated agents that impair translation may lead to IL-1ß-dependent inflammation through activation of the NLRP3 inflammasome. For agents that inhibit translation through decreased cellular potassium, the application of high extracellular potassium restores protein translation and suppresses activation of the NLRP inflammasome. For agents that inhibit translation through mechanisms that do not involve loss of potassium, high extracellular potassium suppresses IL-1ß processing through a mechanism that remains undefined

The concept and the experience of revolution: France 1789--/Russia 1985--.

The historical meaning of the dissolution of the Soviet Union and of the subsequent post-communist transformation remains profoundly unclear. Most observers hesitate to designate these events as a revolution, building on a common-sense notion of revolution as a violent, radical change. My dissertation argues that the post-communist transformation was indeed a revolution and proves this claim by comparing it with the French Revolution, in its political, social, and anthropological aspects. In both historical cases, the quick and easy victory of society over the old regime was followed by a long period of internal struggle, threat of stagnation, and widespread melancholia. Based on this historical parallel, I turn to the theoretical analysis of the concept of revolution. Our recent historical experience allows for a new perspective on the history of this concept, as it has been developed in the Modern philosophy and political theory. The present study focuses primarily on two points in this history. The first is Immanuel Kant's treatment of the French Revolution in his late political texts, The Conflict of the Faculties and The Metaphysics of Morals. The second is Hannah Arendt's work On Revolution. The close reading of these texts allows me to outline the structure of the concept of revolution as centered around the logic of negativity. Kant interprets the French Revolution as an irreversible event. The revolution repeatedly returns to the imaginary, impossible point of self-foundation (which equals self-destruction) only to recoil again from the abyss it opens. Arendt also emphasizes the two sides of revolution, the infinite self-destruction and the new beginning. Although Arendt attempts to separate the positive American Revolution from the negative French Revolution, the dissertation shows that her conceptual reading of the two is identical and that it heavily depends on the narrative structure of tragedy. Revolution is the central concept of the Modern philosophy of history. It is far from being outdated but must be updated and renewed to provide meaning to our present historical situation. This dissertation makes a step towards this renewal.Ph.D.PhilosophyPhilosophy, Religion and TheologyPolitical scienceSocial SciencesUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/123441/2/3079495.pd

Beam profile determination by tomography of solar scans

Beam patterns of radio telescopes with moderate (arcmin) angular resolution in the millimeter and sub-millimeter range are difficult to measure as only weak sources are available in that spectral range. This limitation can be overcome with the deconvolution of radial scans over the knife edge of the solar limb which provides beam profiles down to secondary lobe levels. Numerous applications, such as quick adjustments and checkups of telescope optics, efficiency estimates and the reconstruction of partially unresolved structures such as active regions, become possible. We investigate here the inverse problem of the beam profile reconstruction from the beam convolution with the solar limb. With simple derivatives of solar radial scans we obtained line integrals of the beam profile under different scanning angles. Reconstruction methods used in tomography of filtered reverse projection allowed us then to obtain beam profiles down to the level of secondary lobes. Tests of the algorithm were carried out with simulated data and solar scans that are verified by planet observations and terrestrial beam pattern measurements

Powerful play: Using toys as tools in engineering education

As engineering education has changed to reflect less of a traditional teacher-centered classroom and more of a learner-centered environment, new instructional methodologies have also evolved. Many of these curricular modifications look startlingly different from traditional engineering education at first glance; however, a closer look reveals that some curricular modifications are able to glean the substance of the traditional lecture, mix it up with some learner-based, collaborative, hands-on activities, and integrate the new mandates for technical communication and presentation skills into existing engineering content. More and more frequently, toys are used as cognitive learning tools and manipulative models to aid students in grasping these new skills. But what do these toy-based modifications actually mean to students? Do toys in the classroom actually impact student learning? Our research presents examples of specific innovative curricular modifications ranging from elementary school classrooms to higher education classrooms with one shared finding: toys can be used successfully as teaching tools in this new era of engineering education. We offer examples from all levels of instruction with assessment instruments, pedagogical rationales, and templates for integrating toys as tools into existing engineering courses