Effect of daily consumption of Lactobacillus reuteri CRL 1098 on cholesterol reduction in hypercholesterolemic subjects

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo Controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (-7.86 g/dl) and LDL (-7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.Fil: Malpeli, Agustina. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; ArgentinaFil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Cravero, Ricardo C.. Sancor Cooperativas Unidas Limitada.; ArgentinaFil: Tavella, Marina. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; ArgentinaFil: Fasano, Maria Victoria. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; ArgentinaFil: Vicentin, Dimas. Sancor Cooperativas Unidas Limitada.; ArgentinaFil: Ferrari, Guillermina. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; ArgentinaFil: Magrini, Graciano. Sancor Cooperativas Unidas Limitada.; ArgentinaFil: Hebert, Elvira Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Varea, Ana María. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; ArgentinaFil: Tavella, Julio Marcelo. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; ArgentinaFil: González, Horacio F.. Ministerio de Salud. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri”. Hospital de Niños de La Plata; Argentin

Effect of Daily Consumption of Lactobacillus reuteri CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (−7.86 g/dl) and LDL (−7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.Facultad de Ciencias Médica