439 research outputs found
Methylmercury Contamination of Laboratory Animal Diets
In the midst of research focusing on the neurodevelopmental effects of mercury vapor in rats, we detected significant levels of mercury (30–60 ng/g) in the blood of nonexposed control subjects. We determined that the dominant form of the mercury was organic and that the standard laboratory chow we used in our vivarium was the source of the contamination. The dietary levels were deemed of potential biologic significance, even though they might have fallen below the limits of measurement specified by the supplier. All investigators employing animals in research must assess such potential contamination because dietary agents may alter a) conclusions based on intentionally administered doses, b) outcomes by interacting with other agents that are the primary focus of the research, and c) outcomes of research unrelated to the toxic effects of experimentally administered agents
Studies of Diffuse Interstellar Bands. V. Pairwise Correlations of Eight Strong DIBs and Neutral Hydrogen, Molecular Hydrogen, and Color Excess
We establish correlations between equivalent widths of eight diffuse
interstellar bands (DIBs), and examine their correlations with atomic hydrogen,
molecular hydrogen, and EB-V . The DIBs are centered at \lambda\lambda 5780.5,
6204.5, 6283.8, 6196.0, 6613.6, 5705.1, 5797.1, and 5487.7, in decreasing order
of Pearson\^as correlation coefficient with N(H) (here defined as the column
density of neutral hydrogen), ranging from 0.96 to 0.82. We find the equivalent
width of \lambda 5780.5 is better correlated with column densities of H than
with E(B-V) or H2, confirming earlier results based on smaller datasets. We
show the same is true for six of the seven other DIBs presented here. Despite
this similarity, the eight strong DIBs chosen are not well enough correlated
with each other to suggest they come from the same carrier. We further conclude
that these eight DIBs are more likely to be associated with H than with H2, and
hence are not preferentially located in the densest, most UV shielded parts of
interstellar clouds. We suggest they arise from different molecules found in
diffuse H regions with very little H (molecular fraction f<0.01). Of the 133
stars with available data in our study, there are three with significantly
weaker \lambda 5780.5 than our mean H-5780.5 relationship, all of which are in
regions of high radiation fields, as previously noted by Herbig. The
correlations will be useful in deriving interstellar parameters when direct
methods are not available. For instance, with care, the value of N(H) can be
derived from W{\lambda}(5780.5).Comment: Accepted for publication in The Astrophysical Journal; 37 pages, 11
figures, 6 table
Conjunctions of Among Constraints
Many existing global constraints can be encoded as a conjunction of among
constraints. An among constraint holds if the number of the variables in its
scope whose value belongs to a prespecified set, which we call its range, is
within some given bounds. It is known that domain filtering algorithms can
benefit from reasoning about the interaction of among constraints so that
values can be filtered out taking into consideration several among constraints
simultaneously. The present pa- per embarks into a systematic investigation on
the circumstances under which it is possible to obtain efficient and complete
domain filtering algorithms for conjunctions of among constraints. We start by
observing that restrictions on both the scope and the range of the among
constraints are necessary to obtain meaningful results. Then, we derive a
domain flow-based filtering algorithm and present several applications. In
particular, it is shown that the algorithm unifies and generalizes several
previous existing results.Comment: 15 pages plus appendi
Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment
BACKGROUND: Biomarkers for mercury (Hg) exposure have frequently been used to assess exposure and risk in various groups of the general population. We have evaluated the most frequently used biomarkers and the physiology on which they are based, to explore the inter-individual variations and their suitability for exposure assessment. METHODS: Concentrations of total Hg (THg), inorganic Hg (IHg) and organic Hg (OHg, assumed to be methylmercury; MeHg) were determined in whole blood, red blood cells, plasma, hair and urine from Swedish men and women. An automated multiple injection cold vapour atomic fluorescence spectrophotometry analytical system for Hg analysis was developed, which provided high sensitivity, accuracy, and precision. The distribution of the various mercury forms in the different biological media was explored. RESULTS: About 90% of the mercury found in the red blood cells was in the form of MeHg with small inter-individual variations, and part of the IHg found in the red blood cells could be attributed to demethylated MeHg. THg in plasma was associated with both IHg and MeHg, with large inter-individual variations in the distribution between red blood cells and plasma. THg in hair reflects MeHg exposure at all exposure levels, and not IHg exposure. The small fraction of IHg in hair is most probably emanating from demethylated MeHg. The inter-individual variation in the blood to hair ratio was very large. The variability seemed to decrease with increasing OHg in blood, most probably due to more frequent fish consumption and thereby blood concentrations approaching steady state. THg in urine reflected IHg exposure, also at very low IHg exposure levels. CONCLUSION: The use of THg concentration in whole blood as a proxy for MeHg exposure will give rise to an overestimation of the MeHg exposure depending on the degree of IHg exposure, why speciation of mercury forms is needed. THg in RBC and hair are suitable proxies for MeHg exposure. Using THg concentration in plasma as a measure of IHg exposure can lead to significant exposure misclassification. THg in urine is a suitable proxy for IHg exposure
Services of provincial irrigation offices to communal irrigation systems in Western Visayas, the Philippines
Irrigation management / Communal irrigation systems / Farmer-agency interactions / Maintenance / Farmers' associations / Institution building / Agricultural development / Training / Water distribution / Small-scale systems / Privatization / Philippines
Biobehavioral research on nicotine use in women
More American women are taking up smoking than men and fewer are quitting; if current trends continue, rates for women will surpass those for men by the mid-1990's. But ironically, much of what is known about the biobehavioural aspects of smoking is based on research using male subjects. The present paper reviews evidence suggesting that: (1) women may differ from men with regard to nicotine intake and/or effects; (2) nicotine intake and effects may be influenced by menstrual cycle phase; (3) oral contraceptive use and estrogen replacement therapy may affect intake and effects of nicotine; (4) the effects of chronic nicotine use on female reproductive endocrinology may have implications for the reinforcement of smoking; and (5) pharmacological agents used to treat smoking may have different effects in women than in men. Guidelines and suggestions are presented by future biobehavioural research in women, including standardization of assessment procedures, attention to the use of appropriate controls, and use of pharmacological probes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73978/1/j.1360-0443.1991.tb01802.x.pd
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