DISTRIBUCIÓN DE LAS ÁREAS VERDES, ÍNDICE DE MARGINACIÓN Y JUSTICIA AMBIENTAL EN LEÓN, GUANAJUATO

Las áreas verdes constituyen un elemento estratégico para la sostenibilidad de las ciudades, ya que poseen cualidades que derivan en la mejora de la calidad de vida y el bienestar social. No obstante, la ciudad de León, Guanajuato, muestra una distribución desigual y deficitaria en la dotación de áreas verdes, lo cual se manifiesta en una exclusión socio-espacial de los beneficios que estos espacios brindan a toda la población. El trabajo evidencia que las zonas con menor índice de áreas verdes coinciden con las zonas de mayor índice de marginación, especialmente en el caso de los siete polígonos de pobreza de ciudad. El reto que subyace para la ciudad es lograr una distribución justa y equitativa de las áreas verdes, mediante instrumentos de planificación que permitan lograr la sostenibilidad urbana, con justicia ambiental y correlacionarse positivamente con los índices de marginación

Hazard ratio of CRC risk defined by KRAS and BRAF mutation status in women.

<p>Adjusted for age, sex, level of education, smoking habits and alcohol consumption. * significant p for heterogeneity.</p

Hazard ratio of overall CRC risk defined by KRAS and BRAF mutation status

<p>Adjusted for age, sex, level of education, smoking habits and alcohol consumption. ¶ significant interaction with sex.</p

Distribution of risk factors in cases and rest of cohort

<p>Distribution of risk factors in cases and rest of cohort</p

Padhan BMC Cancer 2016 Supplemental Results

File contains the test statistic (T) for each possible combination of 1-3 features, including the constructed features (column 5 and 6). One combination is shown per row with the name of the feature combination in the first column and the header explaining the value in each column in the first row

Raw Protein RPAs Constructed features replicate corrected

File shows the relative peak area (RPA), i.e. peak area value of the measured protein after normalization to the HSP70 level analyzed in parallel in each sample (columns 2-24, 28-42). This file contains one sample per row and one protein per column with the sample name in the first column and the protein name in the first row. Column 25-27 contain the result of the mutation analysis of KRAS and BRAF. One in column 25 (MutationKRAS) indicate that KRAS is mutated in the sample, one in column 26 (MutationBRAF) indicates that BRAF is mutated, while one in column 27 (Wildtype) indicate that neither KRAS nor BRAF is mutated. Columns 28 to 42 contain the RPA values of the constructed features, i.e. features that are calculated based on the 23 different activity levels of the 7 signal transducers in column 2-24. The four replicates of each constructed feature contains the minimum, maximum, mean, and median value based on all possible ways to combine the replicates of the proteins used to construct the feature. A one in the binary variables in column 43-46 indicate the classification of each sample as normal mucosa, colorectal cancer (CRC) stage II, CRC stage IV, or metastasis. In the last column the classification is 1 = normal mucosa, 2 = colorectal cancer (CRC) stage II, 3 = CRC stage IV, or 5 = metastasis. NaN is used to indicate that no measurement was done

Additional file 1: of High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Figure S1. Validation of antibodies used in the study by conventional immunoblotting. All antibodies showed immunoreactivity with the expected molecular species, in conventional immunoblotting on endothelial lysates. Figure S2. Detection of MEK1/2 protein by isoelectric focusing. There was no significant difference in MEK protein expression between normal, CRCII and CRCIV tissues. Detailed description of computational analyses; “Characterization of the data set and errors”. Figure S3. Distribution function for data subsets by Monte Carlo simulation. (DOCX 1215 kb

Raw Protein RPAs

The relative peak area (RPA), i.e. peak area value of the 23 different activity levels of the 7 signal transducers after normalization to the HSP70 level analyzed in parallel in each sample (columns 2-24). This file contains one sample per row and one protein per column with the sample name in the first column and the protein name in the first row. Columns 25-27 contain the result of the mutation analysis of KRAS and BRAF. One in column 25 (MutationKRAS) indicate that KRAS is mutated in the sample, one in column 26 (MutationBRAF) indicates that BRAF is mutated, while one in column 27 (Wildtype) indicate that neither KRAS nor BRAF is mutated. A one in the binary variables in column 28-31 indicate the classification of each sample as normal mucosa, colorectal cancer (CRC) stage II, CRC stage IV, or metastasis. NaN is used to indicate that no measurement was done

MOESM2 of Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

Additional file 2. Comparison of EGFR protein expression in CRC assessed by two different antibodies in cohort 1

MOESM1 of Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

Additional file 1. Patient and tumour characteristics in the three cohorts