Professional Exposure to Goats Increases the Risk of Pneumonic-Type Lung Adenocarcinoma: Results of the IFCT-0504-Epidemio Study

Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR) = 3.23, 95% confidence interval (CI): 1.32–7.87, p = 0.010), never- smoker status (OR = 3.57, 95% CI: 1.27–10.00, p = 0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (OR = 3.43, 95% CI: 1.10–10.72, p = 0.034), and professional exposure to goats (OR = 5.09, 95% CI: 1.05–24.69, p = 0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC

La vaccination HPV (perception et pratique des médecins de la région Rhône-Alpes)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma. Results of the IFCT-0504-epidemio study

International audienc

Prevention of sexually transmitted infections among girls and young women in relation to their HPV vaccination status.

International audienceBACKGROUND: Having been vaccinated against the human papilloma virus (HPV) may affect other behaviours related to sexual health. This study assessed knowledge and behaviour relevant to the prevention of sexually transmitted infections (STIs) among girls/women aged 14-23 years in relation to their HPV vaccination status. METHODS: From November 2008 to February 2009, 328 girls/women from the Rhône-Alpes region were recruited by general practitioners and completed a self-administered questionnaire. RESULTS: In all, 316 of the 328 respondents provided information on their HPV vaccination status: 135 (42.7%) had been vaccinated (51.2% of girls aged 14-16 years, 44% of women aged 17-20 years and 18.9% of 21-23-year-olds). Knowledge about HPV and the Pap smear was poor overall but greater in those who had been vaccinated: vaccinated 14-16-year-olds were significantly more likely to know the aim of the Pap smear than those not vaccinated (72.7% vs. 41.3%, P 80% cited condoms as a means of STI prevention and >85% of those who were sexually active used them. No difference was observed between vaccinated and non-vaccinated groups regarding requests for HIV serology, history of abortions or emergency hormonal contraception. CONCLUSION: Knowledge about cervical cancer prevention was better among those who had been vaccinated against HPV than among those who had not. Knowledge and behaviour relevant to STI prevention seemed appropriate whatever the respondents' vaccination status

Disparities of Perceptions and Practices Related to Cervical Cancer Prevention and the Acceptability of HPV Vaccination According to Educational Level in a French Cross-Sectional Survey of 18–65 Years Old Women

<div><p>Introduction</p><p>We aimed to study the relationships between educational level, women's knowledge about cervical cancer (CC), and acceptance of HPV vaccination for their daughters.</p><p>Methods</p><p>We analysed data from a quantitative (self-administrated questionnaire) and qualitative (semi-structured interviews) cross-sectional study performed in 2008 among 1,229 French 18–65-year-old women recruited by general practitioners. Women were categorized into three educational level groups: low (LEL: 43.9%), medium (MEL: 33.4%) and high (HEL: 22.6%).</p><p>Results</p><p>Knowledge about CC and its prevention was lower among LEL women. In the 180 mothers of 14–18-year-old daughters (99 LEL, 54 MEL, 45 HEL), acceptance of HPV vaccine was higher in LEL (60.4%) and MEL (68.6%) than in HEL mothers (46.8%). Among LEL mothers, those who were favourable to HPV vaccination were more likely to be young (OR = 8.44 [2.10–34.00]), to be vaccinated against hepatitis B (OR = 4.59 [1.14–18.52]), to have vaccinated their children against pneumococcus (OR = 3.52 [0.99–12.48]) and to present a history of abnormal Pap smear (OR = 6.71 [0.70–64.01]).</p><p>Conclusion</p><p>Although LEL women had poorer knowledge about CC and its prevention, they were more likely to accept HPV vaccination than HEL mothers.</p></div

Sociodemographic characteristics and preventive health behaviours of survey participants according to educational level.

<p>LEL: Low education level, MEL: Medium education level, HEL: High education level, DTP: Diphtheria-tetanus-poliomyelitis.</p>1<p>Beneficiary of public free health insurance and/or minimal financial allocation for non workers.</p>2<p>N = 1,012 mothers: 467 LEL, 326 MEL and 219 HEL.</p><p>Sociodemographic characteristics and preventive health behaviours of survey participants according to educational level.</p

Acceptability of HPV vaccination: options presented in the self-administered questionnaire, and the coding of responses.

<p>Acceptability of HPV vaccination: options presented in the self-administered questionnaire, and the coding of responses.</p

Univariate analysis of factors associated with HPV vaccination acceptance among mothers with a low educational level (N = 91).

<p>Results are presented as N (%)/N(%) for number and percent for the tested category versus number and percent for the reference category.</p><p>OR: Odds ratio, CI: confidence interval, vs: versus, STI, Sexually transmitted infection.</p><p>Univariate analysis of factors associated with HPV vaccination acceptance among mothers with a low educational level (N = 91).</p

HPV vaccine acceptance among mothers of 14–18 year old daughters (N = 188).

<p>LEL: Low education level, MEL: Medium education level, HEL: High education level.</p><p>HPV vaccine acceptance among mothers of 14–18 year old daughters (N = 188).</p

Multivariate analysis of factors associated with HPV vaccination acceptance among mothers with a low educational level (N = 91).

†<p>: first model, output threshold = 0.05, ‡: second model, output threshold = 0.10, <i>OR: Odd ratio, CI: confidence interval, NS not significant</i>.</p><p>Multivariate analysis of factors associated with HPV vaccination acceptance among mothers with a low educational level (N = 91).</p