A physical activity program dedicated to adolescents

Adolescence is a life stage in which the development ofindividuality and self-identity occurs.The recent study of the SIP evaluated the life style inadolescents, highlighting thelow participation to conti-nuative sports programs and the high incidence tosports drop out, interesting more than 30% of adoles-cents. These problems are partially linked to low com-pliance of adolescents to coaches training, partially tothe request of a sport close to adolescents requirements.However sports participation is beneficial for physicaland psychological development of adolescents. Sports pro-grams promote responsible social behaviours and greateracademic success, confidence in personal physical abilities,appreciation of personal health and fitness and strongsocial bonds with individuals and institutions. Adolescentsinvolved in physical activities fare better academically,have higher relationship skills, are more team-orientedand are healthier as determined by fitness standards.For these reasons the program of the physical activitydedicated to the adolescent needs a personal evaluation ofown desires and personal abilities, with a daily promotionof an active life style, preferring group activities (to go toschool and to come back home by foot or by bike withfriends, to walk for familial needs, etc.). The sport choicemust be carried out together with them, in order to guar-antee a four times a week physical activity, in conformitywith scholastic needs. Once a week they need to have spe-cial physical activities in accordance to familial requests.The skills of this program are: the education to amaintained physical assignment; the prevention of socialdeviation and/or alcohol, smoke, drugs dependence; theeducation to roles and rules, responsibilities, loyalty,cooperation, friendship

Simbol-X capability of detecting the non-thermal emission of stellar flares

We investigate the capability of detecting, with Simbol-X, non-thermal emission during stellar flares, and distinguishing it from hot thermal emission. We find that flare non-thermal emission is detectable when at least ~20 cts are detected with the CZT detector in the 20-80 keV band. Therefore Simbol-X will detect the non-thermal emission from some of the X-ray brightest nearby stars, whether the thermal vs. non-thermal relation, derived for solar flares, holds.Comment: 2 pages, 2 postscript figures, proceedings of the workshop "Simbol-X: the hard X-ray universe in focus", to be published in "Memorie of the Italian Astronomical Society

Discrete-time dynamic modeling for software and services composition as an extension of the Markov chain approach

Discrete Time Markov Chains (DTMCs) and Continuous Time Markov Chains (CTMCs) are often used to model various types of phenomena, such as, for example, the behavior of software products. In that case, Markov chains are widely used to describe possible time-varying behavior of “self-adaptive” software systems, where the transition from one state to another represents alternative choices at the software code level, taken according to a certain probability distribution. From a control-theoretical standpoint, some of these probabilities can be interpreted as control signals and others can just be observed. However, the translation between a DTMC or CTMC model and a corresponding first principle model, that can be used to design a control system is not immediate. This paper investigates a possible solution for translating a CTMC model into a dynamic system, with focus on the control of computing systems components. Notice that DTMC models can be translated as well, providing additional information

Design and Implementation of Distributed Resource Management for Time Sensitive Applications

In this paper, we address distributed convergence to fair allocations of CPU resources for time-sensitive applications. We propose a novel resource management framework where a centralized objective for fair allocations is decomposed into a pair of performance-driven recursive processes for updating: (a) the allocation of computing bandwidth to the applications (resource adaptation), executed by the resource manager, and (b) the service level of each application (service-level adaptation), executed by each application independently. We provide conditions under which the distributed recursive scheme exhibits convergence to solutions of the centralized objective (i.e., fair allocations). Contrary to prior work on centralized optimization schemes, the proposed framework exhibits adaptivity and robustness to changes both in the number and nature of applications, while it assumes minimum information available to both applications and the resource manager. We finally validate our framework with simulations using the TrueTime toolbox in MATLAB/Simulink

Lack of Effect of Murine Norovirus Infection on a Mouse Model of Bacteria-Induced Colon Cancer

Murine norovirus (MNV) is endemic in mouse research facilities in the United States and Europe, with a prevalence as high as 58% to 64%. Because of MNV's orofecal route of infection, clinically silent persistent infections in some mouse strains, and proclivity for macrophage and dendritic cells, its presence in mouse colonies has potential to alter phenotypes in experimental mouse models, particularly those involving inflammation and immunologic responses. Although MNV is subclinical, not causing overt disease in immunocompetent mice, we found that MNV infection can accelerate bacteria-induced inflammatory bowel disease (IBD) progression in Mdr1a^(-/-) mice. The studies presented here examined whether MNV infection also affects the phenotype of a bacterially driven mouse model of inflammation-associated colon cancer in genetically susceptible Smad3^(-/-) mice. In vitro culture of bone-marrow—derived macrophages (BMDM) was used to determine whether MNV4 influenced macrophage cytokine production. For in vivo studies, Smad3-/- mice were infected with MNV4 one week prior to infection with Helicobacter. Mice were monitored for 17 to 32 wk for development of IBD and colon cancer, and tissues were analyzed histopathologically. Although in vitro infection of BMDM with MNV4 led to increased inflammatory cytokine production, infection with MNV4 in vivo did not result in any statistically significant differences in survival, IBD scores, tumor incidence, or tumor phenotype in Smad3^(-/-) mice. In addition, MNV infection alone did not result in IBD or colon cancer. Therefore MNV infection alone or in conjunction with Helicobacter does not alter the development or progression of IBD or colon cancer in Smad3^(-/-) mice

Kawasaki disease triggered by EBV virus in a child with Familial Mediterranean Fever

Familial Mediterranean Fever is a monogenic autoinflammatory disease, secondary to mutation of MEFV gene, and typically expressed with recurrent attacks of fever, serositis, rash, aphthous changes in lips and/or oral mucosa. Kawasaki Disease, an acute systemic vasculitis with persistent fever (5 or more days), rash, stomatitis, conjunctivitis, lymphadenopathy, changes in extremities, is currently considered a multifactorial autoinflammatory disease. An infection, as Epstein Barr virus, can be the trigger of Kawasaki Disease

Comment on ``Quasiparticle Spectra around a Single Vortex in a d-wave Superconductor''

In a recent Letter Morita, Kohmoto and Maki analyzed the structure of quasiparticle states near a single vortex in a d-wave superconductor using an approximate version of the Bogoliubov - de Gennes theory. Their principal result is the existence of a bound state within the core region at finite energy with full rotational symmetry, which they assert explains the recent scanning tunneling microscopy results on YBCO single crystals. Here we argue that the approximation used in this work is fundamentally inadequate for the description of a d-wave vortex and that the obtained circular symmetry of the local density of states is an unphysical artifact of this approximation.Comment: 1 page REVTeX, to appear in PR

Strong-coupling analysis of scanning tunneling spectra in Bi2_2Sr2_2Ca2_2Cu3_3O10+δ_{10+\delta}

We study a series of spectra measured in the superconducting state of optimally-doped Bi-2223 by scanning tunneling spectroscopy. Each spectrum, as well as the average of spectra presenting the same gap, is fitted using a strong-coupling model taking into account the band structure, the BCS gap, and the interaction of electrons with the spin resonance. After describing our measurements and the main characteristics of the strong-coupling model, we report the whole set of parameters determined from the fits, and we discuss trends as a function of the gap magnitude. We also simulate angle-resolved photoemission spectra, and compare with recent experimental results.Comment: Published versio

Familial Mediterranean Fever: An unusual cause of liver disease

Background Familial Mediterranean Fever is an autoinflammatory disease typically expressed with recurrent attacks of fever, serositis, aphthous stomatitis, rash. Only a few reports describe the association with hepatic involvement. Case presentation We describe the clinical case of a child affected, since the age of 1 year, by recurrent fever, aphthous stomatitis, rash, arthralgia, associated with abdominal pain, vomiting, lymphadenopathy. The diagnosis of Familial Mediterranean Fever was confirmed by the genetic study of MEFV gene; the homozygous mutation M694 V in exon was documented. A partial control of attacks was obtained with colchicine. The child continued to manifest only recurrent episodes of abdominal pain without fever, however serum amyloid A persisted high, in association with enhanced levels of CRP, AST and ALT (1.5 x n.v.). The dosage of colchicine was increased step by step and the patient achieved a better control of symptoms and biochemical parameters. However, the patient frequently needed an increase in the dose of colchicine, suggesting the possible usefulness of anti-interleukin-1 beta treatment. Conclusions The unusual presentation of Familial Mediterranean Fever with liver disease suggests the role of inflammasome in hepatic inflammation. Colchicine controls systemic inflammation in most of the patients; however, subclinical inflammation can persist in some of them and can manifest with increased levels of CRP, ESR, serum amyloid A also in attack-free intervals