Aerosol physical properties in the stratosphere (APPS) radiometer design

The measurement concepts and radiometer design developed to obtain earth-limb spectral radiance measurements for the Aerosol Physical Properties in the Stratosphere (APPS) measurement program are presented. The measurements made by a radiometer of this design can be inverted to yield vertical profiles of Rayleigh scatterers, ozone, nitrogen dioxide, aerosol extinction, and aerosol physical properties, including a Junge size-distribution parameter, and a real and imaginary index of refraction. The radiometer design provides the capacity for remote sensing of stratospheric constituents from space on platforms such as the space shuttle and satellites, and therefore provides for global measurements on a daily basis

Underuse of coronary revascularization procedures in patients considered appropriate candidates for revascularization.

Background: Ratings by an expert panel of the appropriateness of treatments may offer better guidance for clinical practice than the variable decisions of individual clinicians, yet there have been no prospective studies of clinical outcomes. We compared the clinical outcomes of patients treated medically after angiography with those of patients who underwent revascularization, within groups defined by ratings of the degree of appropriateness of revascularization in varying clinical circumstances.Methods: This was a prospective study of consecutive patients undergoing coronary angiography at three London hospitals. Before patients were recruited, a nine-member expert panel rated the appropriateness of percutaneous transluminal coronary angioplasty (PTCA) and coronary-artery bypass grafting (CABG) on a nine-point scale (with 1 denoting highly inappropriate and 9 denoting highly appropriate) for specific clinical indications. These ratings were then applied to a population of patients with coronary artery disease. However, the patients were treated without regard to the ratings. A total of 2552 patients were followed for a median of 30 months after angiography.Results: Of 908 patients with indications for which PTCA was rated appropriate (score, 7 to 9), 34 percent were treated medically; these patients were more likely to have angina at follow-up than those who underwent PTCA (odds ratio, 1.97; 95 percent confidence interval, 1.29 to 3.00). Of 1353 patients with indications for which CABG was considered appropriate, 26 percent were treated medically; they were more likely than those who underwent CABG to die or have a nonfatal myocardial infarction - the composite primary outcome (hazard ratio, 4.08; 95 percent confidence interval, 2.82 to 5.93) - and to have angina (odds ratio, 3.03; 95 percent confidence interval, 2.08 to 4.42). Furthermore, there was a graded relation between rating and outcome over the entire scale of appropriateness (P for linear trend = 0.002).Conclusions: On the basis of the ratings of the expert panel, we identified substantial underuse of coronary revascularization among patients who were considered appropriate candidates for these procedures. Underuse was associated with adverse clinical outcomes. (N Engl J Med 2001;344:645-54.) Copyright (C) 2001 Massachusetts Medical Society

Probing the Dawn of Galaxies at z~9-12: New Constraints from HUDF12/XDF and CANDELS Data

We present a comprehensive analysis of z>8 galaxies based on ultra-deep WFC3/IR data. We constrain the evolution of the UV luminosity function (LF) and luminosity densities from z~11 to z~8 by exploiting all the WFC3/IR data over the Hubble Ultra-Deep Field from the HUDF09 and the new HUDF12 program, in addition to the HUDF09 parallel field data, as well as wider area WFC3/IR imaging over GOODS-South. Galaxies are selected based on the Lyman Break Technique in three samples centered around z~9, z~10 and z~11, with seven z~9 galaxy candidates, and one each at z~10 and z~11. We confirm a new z~10 candidate (with z=9.8+-0.6) that was not convincingly identified in our first z~10 sample. The deeper data over the HUDF confirms all our previous z>~7.5 candidates as genuine high-redshift candidates, and extends our samples to higher redshift and fainter limits (H_160~29.8 mag). We perform one of the first estimates of the z~9 UV LF and improve our previous constraints at z~10. Extrapolating the lower redshift UV LF evolution should have revealed 17 z~9 and 9 z~10 sources, i.e., a factor ~3x and 9x larger than observed. The inferred star-formation rate density (SFRD) in galaxies above 0.7 M_sun/yr decreases by 0.6+-0.2 dex from z~8 to z~9, in good agreement with previous estimates. The low number of sources found at z>8 is consistent with a very rapid build-up of galaxies across z~10 to z~8. From a combination of all current measurements, we find a best estimate of a factor 10x decrease in the SFRD from z~8 to z~10, following (1+z)^(-11.4+-3.1). Our measurements thus confirm our previous finding of an accelerated evolution beyond z~8, and signify a rapid build-up of galaxies with M_UV<-17.7 within only ~200 Myr from z~10 to z~8, in the heart of cosmic reionization.Comment: 21 pages, 13 figures, 6 tables; submitted to Ap

HPV Vaccine Reminders at the Point of Service: Efficacy and Missed Opportunities. A Claims Based Study within One Health Plan

Introduction: Our objective is to assess HPV vaccine series completion rates, whether on-screen Point of Service reminders (POS) make a difference, and missed opportunities for reminders to have an effect. Methods: Retrospective, claims-based study of females aged 9-26 receiving an initial dose of HPV vaccine during 2 periods: before (period 1) and after (period 2) implementation of a POS reminder system in 1(“Change Group”) of 2 physician groups using EHRs for both periods. Completion rates, and missed opportunities during eligible periods were calculated for those with continuous enrollment in the health plan investigated. Results: Completion rates within 1 year of the 1st dose were Period 1: 47% Change Group vs. 46% Control Group (p=0.847). Period 2: 50% Change group vs. 57% Control Group (p=0.158). No significant improvement occurred between the 2 periods in either group. Differences in 1 year completion rates by specialty of initiating provider or age group (≥18) were not significant. During period 2, among those with continuous insurance plan enrollment in the Change Group, 43 patients received 1 dose and 46 received 2 doses. Of those receiving 1 dose, 30 (70%) had a visit to the same group within an eligible time period (median # visits: 2, range 1-20); of those completing 2 doses, 4 (9%) had a visit to the same group within an eligible period (median # visits: 1, range: 1-3). Among those receiving 1 dose, 25 (58%) had a visit to the same group and same specialty as the initial dose (median # visits: 1, range 1-8); for those having received 2 doses, 3 (6%) had a subsequent visit to same group and specialty (median # visits: 1, range 1-3). Conclusion: POS reminder systems was not associated with improved completion rates. POS reminders are limited by infrequent visits among non-completers in an eligible period

A Rest-frame Optical View on z~4 Galaxies I: Color and Age Distributions from Deep IRAC Photometry of the IUDF10 and GOODS Surveys

We present a study of rest-frame UV-to-optical color distributions for z~4 galaxies based on the combination of deep HST/ACS+WFC3/IR data with Spitzer/IRAC imaging. In particular, we use new, ultra-deep data from the IRAC Ultradeep Field program (IUDF10). Our sample contains a total of ~2600 galaxies selected as B-dropout Lyman Break Galaxies (LBGs) in the HUDF and one of its deep parallel fields, the HUDF09-2, as well as GOODS-North and South. This sample is used to investigate the UV continuum slopes beta and Balmer break colors (J_125-[4.5]) as a function of rest-frame optical luminosity. The [4.5] filter is chosen to avoid potential contamination by strong rest-frame optical emission lines. We find that galaxies at M_z<-21.5 (roughly corresponding to L*[z~4]) are significantly redder than their lower luminosity counterparts. The UV continuum slopes and the J_125-[4.5] colors are well correlated. The most simple explanation for this correlation is that the dust reddening at these redshifts is better described by an SMC-like extinction curve, rather than the typically assumed Calzetti reddening. After correcting for dust, we find that the galaxy population shows mean stellar population ages in the range 10^8.5 to 10^9 yr, with a dispersion of ~0.5 dex, and only weak trends as a function of luminosity. In contrast to some results from the literature, we find that only a small fraction of galaxies shows Balmer break colors which are consistent with extremely young ages, younger than 100 Myr. Under the assumption of smooth star-formation histories, this fraction is only 12-19% for galaxies at M_z<-19.75. Our results are consistent with a gradual build-up of stars and dust in galaxies at z>4, with only a small fraction of stars being formed in short, intense bursts of star-formation.Comment: 11 pages, 10 figures; submitted to Ap

Photometric Constraints on the Redshift of z~10 candidate UDFj-39546284 from deeper WFC3/IR+ACS+IRAC observations over the HUDF

Ultra-deep WFC3/IR observations on the HUDF from the HUDF09 program revealed just one plausible z~10 candidate UDFj-39546284. UDFj-39546284 had all the properties expected of a galaxy at z~10 showing (1) no detection in the deep ACS+WFC3 imaging data blueward of the F160W band, exhibiting (2) a blue spectral slope redward of the break, and showing (3) no prominent detection in deep IRAC observations. The new, similarly deep WFC3/IR HUDF12 F160W observations over the HUDF09/XDF allow us to further assess this candidate. These observations show that this candidate, previously only detected at ~5.9 sigma in a single band, clearly corresponds to a real source. It is detected at ~5.3 sigma in the new H-band data and at ~7.8 sigma in the full 85-orbit H-band stack. Interestingly, the non-detection of the source (<1 sigma) in the new F140W observations suggests a higher redshift. Formally, the best-fit redshift of the source utilizing all the WFC3+ACS (and IRAC+K-band) observations is 11.8+/-0.3. However, we consider the z~12 interpretation somewhat unlikely, since the source would either need to be ~20x more luminous than expected or show very high-EW Ly-alpha emission (which seems improbable given the extensive neutral gas prevalent early in the reionization epoch). Lower-redshift solutions fail if only continuum models are allowed. Plausible lower-redshift solutions require that the H-band flux be dominated by line emission such as Halpha or [OIII] with extreme EWs. The tentative detection of line emission at 1.6 microns in UDFj-39546284 in a companion paper suggests that such emission may have already been found.Comment: 6 pages, 4 figures, 1 table, accepted for publication in ApJ Letters, updated to match the version in pres

A Spectroscopic Redshift Measurement for a Luminous Lyman Break Galaxy at z=7.730 using Keck/MOSFIRE

We present a spectroscopic redshift measurement of a very bright Lyman break galaxy at z=7.7302+-0.0006 using Keck/MOSFIRE. The source was pre-selected photometrically in the EGS field as a robust z~8 candidate with H=25.0 mag based on optical non-detections and a very red Spitzer/IRAC [3.6]-[4.5] broad-band color driven by high equivalent width [OIII]+Hbeta line emission. The Lyalpha line is reliably detected at 6.1 sigma and shows an asymmetric profile as expected for a galaxy embedded in a relatively neutral inter-galactic medium near the Planck peak of cosmic reionization. The line has a rest-frame equivalent width of EW0=21+-4 A and is extended with V_FWHM=360+90-70 km/s. The source is perhaps the brightest and most massive z~8 Lyman break galaxy in the full CANDELS and BoRG/HIPPIES surveys, having assembled already 10^(9.9+-0.2) M_sol of stars at only 650 Myr after the Big Bang. The spectroscopic redshift measurement sets a new redshift record for galaxies. This enables reliable constraints on the stellar mass, star-formation rate, formation epoch, as well as combined [OIII]+Hbeta line equivalent widths. The redshift confirms that the IRAC [4.5] photometry is very likely dominated by line emission with EW0(OIII+Hbeta)= 720-150+180 A. This detection thus adds to the evidence that extreme rest-frame optical emission lines are a ubiquitous feature of early galaxies promising very efficient spectroscopic follow-up in the future with infrared spectroscopy using JWST and, later, ELTs.Comment: 6 pages, 4 figures, small updates to match ApJL accepted versio