Extensive lava flow fields on Venus: Preliminary investigation of source elevation and regional slope variations

Large-volume lava flow fields have been identified on Venus, the most areally extensive of which are known as fluctus and have been subdivided into six morphologic types. Sheetlike flow fields (Type 1) lack the numerous, closely spaced, discrete lava flow lobes that characterize digitate flow fields. Transitional flow fields (Type 2) are similar to sheetlike flow fields but contain one or more broad flow lobes. Digitate flow fields are divided further into divergent (Types 3-5) and subparallel (Type 6) classes on the basis of variations in the amount of downstream flow divergence. As a result of our previous analysis of the detailed morphology, stratigraphy, and tectonic associations of Mylitta Fluctus, we have formulated a number of questions to apply to all large flow fields on Venus. In particular, we would like to address the following: (1) eruption conditions and style of flow emplacement (effusion rate, eruption duration), (2) the nature of magma storage zones (presence of neutral buoyancy zones, deep or shallow crustal magma chambers), (3) the origin of melt and possible link to mantle plumes, and (4) the importance of large flow fields in plains evolution. To answer these questions we have begun to examine variations in flow field dimension and morphology; the distribution of large flow fields in terms of elevation above the mean planetary radius; links to regional tectonic or volcanic structures (e.g., associations with large shield edifices, coronae, or rift zones); statigraphic relationships between large flow fields, volcanic plains, shields, and coronae; and various models of flow emplacement in order to estimate eruption parameters. In this particular study, we have examined the proximal elevations and topographic slopes of 16 of the most distinctive flow fields that represent each of the 6 morphologic types

A geochemical investigation of regional sedimentary-hosted Pb-Zn mineralization in the Paleoproterozoic Karrat Group, West Greenland

Pb-Zn mineralization is hosted in two formations of the Karrat Group in arctic West Greenland: the Marmorilik Formation (carbonate-hosted, 12.3% Pb, 4.0% Zn, 29ppm Ag), home to the historical Black Angel Mine, and the recently defined Qaarsukassak Formation (shale-carbonate-hosted, ~20% Zn). These two sedimentary units were deposited directly on crystalline basement rocks and might have similar depositional timing, however, they are separated by a basement topographic high and are not observed in stratigraphic contact. The timing of their mineralization is also enigmatic. This study uses a combination of field and geochemical approaches to understand the origin of the Pb-Zn mineralization in both formations by using the following methods: field mapping, petrography, pyrite and ore sulfide sulfur isotope analysis, Pb isotopic analysis, and Re-Os analysis of pyrite grains associated with the mineralization. Marmorilik and Qaarsukassak mineralization textures suggest a late stage remobilization event after the emplacement of ore mineralization. Additionally, remobilized sulfides from both formations are linked to the regional D3 deformation, thus constraining the mineralization prior to D3 deformation. Sulfur isotope results from both traditional isotope-ratio mass spectrometry and secondary ion mass spectrometry show a range of 34S values between +0.2‰ and +7.2‰ on sulfide minerals, suggesting contributions from both bacterially reduced and thermochemically reduced seawater sulfate. Pb-Pb isotopic analysis of galena from the Marmorilik Formation shows a homogenous signature (206Pb/204Pb = 16.091-16.102 and 207Pb/204Pb = 15.378-15.385), with Pb isotopic compositions consistent with a crustal source for Pb, indicating local basement as a likely source for the metals. Results from Re-Os analysis of pyrite grains derive an indicated age of 1919 Ma +/- 44 Ma, providing a maximum age constraint for the mineralization. Combining structural, petrographic, and Re-Os isotopic data, a timeframe for the Pb-Zn mineralization of ca. > 1900 to < 1830 Ma is proposed. Sulfur isotope results suggest a SEDEX model for the mineralization, while petrographic, Pb-Pb, and Re-Os isotope results could indicate either a SEDEX or MVT type model

Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types.

Isoforms of human miRNAs (isomiRs) are constitutively expressed with tissue- and disease-subtype-dependencies. We studied 10 271 tumor datasets from The Cancer Genome Atlas (TCGA) to evaluate whether isomiRs can distinguish amongst 32 TCGA cancers. Unlike previous approaches, we built a classifier that relied solely on \u27binarized\u27 isomiR profiles: each isomiR is simply labeled as \u27present\u27 or \u27absent\u27. The resulting classifier successfully labeled tumor datasets with an average sensitivity of 90% and a false discovery rate (FDR) of 3%, surpassing the performance of expression-based classification. The classifier maintained its power even after a 15× reduction in the number of isomiRs that were used for training. Notably, the classifier could correctly predict the cancer type in non-TCGA datasets from diverse platforms. Our analysis revealed that the most discriminatory isomiRs happen to also be differentially expressed between normal tissue and cancer. Even so, we find that these highly discriminating isomiRs have not been attracting the most research attention in the literature. Given their ability to successfully classify datasets from 32 cancers, isomiRs and our resulting \u27Pan-cancer Atlas\u27 of isomiR expression could serve as a suitable framework to explore novel cancer biomarkers

MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects.

MINTbase is a repository that comprises nuclear and mitochondrial tRNA-derived fragments (\u27tRFs\u27) found in multiple human tissues. The original version of MINTbase comprised tRFs obtained from 768 transcriptomic datasets. We used our deterministic and exhaustive tRF mining pipeline to process all of The Cancer Genome Atlas datasets (TCGA). We identified 23 413 tRFs with abundance of ≥ 1.0 reads-per-million (RPM). To facilitate further studies of tRFs by the community, we just released version 2.0 of MINTbase that contains information about 26 531 distinct human tRFs from 11 719 human datasets as of October 2017. Key new elements include: the ability to filter tRFs on-the-fly by minimum abundance thresholding; the ability to filter tRFs by tissue keywords; easy access to information about a tRF\u27s maximum abundance and the datasets that contain it; the ability to generate relative abundance plots for tRFs across cancer types and convert them into embeddable figures; MODOMICS information about modifications of the parental tRNA, etc. Version 2.0 of MINTbase contains 15x more datasets and nearly 4x more distinct tRFs than the original version, yet continues to offer fast, interactive access to its contents. Version 2.0 is available freely at http://cm.jefferson.edu/MINTbase/

Aerosol physical properties in the stratosphere (APPS) radiometer design

The measurement concepts and radiometer design developed to obtain earth-limb spectral radiance measurements for the Aerosol Physical Properties in the Stratosphere (APPS) measurement program are presented. The measurements made by a radiometer of this design can be inverted to yield vertical profiles of Rayleigh scatterers, ozone, nitrogen dioxide, aerosol extinction, and aerosol physical properties, including a Junge size-distribution parameter, and a real and imaginary index of refraction. The radiometer design provides the capacity for remote sensing of stratospheric constituents from space on platforms such as the space shuttle and satellites, and therefore provides for global measurements on a daily basis

Underuse of coronary revascularization procedures in patients considered appropriate candidates for revascularization.

Background: Ratings by an expert panel of the appropriateness of treatments may offer better guidance for clinical practice than the variable decisions of individual clinicians, yet there have been no prospective studies of clinical outcomes. We compared the clinical outcomes of patients treated medically after angiography with those of patients who underwent revascularization, within groups defined by ratings of the degree of appropriateness of revascularization in varying clinical circumstances.Methods: This was a prospective study of consecutive patients undergoing coronary angiography at three London hospitals. Before patients were recruited, a nine-member expert panel rated the appropriateness of percutaneous transluminal coronary angioplasty (PTCA) and coronary-artery bypass grafting (CABG) on a nine-point scale (with 1 denoting highly inappropriate and 9 denoting highly appropriate) for specific clinical indications. These ratings were then applied to a population of patients with coronary artery disease. However, the patients were treated without regard to the ratings. A total of 2552 patients were followed for a median of 30 months after angiography.Results: Of 908 patients with indications for which PTCA was rated appropriate (score, 7 to 9), 34 percent were treated medically; these patients were more likely to have angina at follow-up than those who underwent PTCA (odds ratio, 1.97; 95 percent confidence interval, 1.29 to 3.00). Of 1353 patients with indications for which CABG was considered appropriate, 26 percent were treated medically; they were more likely than those who underwent CABG to die or have a nonfatal myocardial infarction - the composite primary outcome (hazard ratio, 4.08; 95 percent confidence interval, 2.82 to 5.93) - and to have angina (odds ratio, 3.03; 95 percent confidence interval, 2.08 to 4.42). Furthermore, there was a graded relation between rating and outcome over the entire scale of appropriateness (P for linear trend = 0.002).Conclusions: On the basis of the ratings of the expert panel, we identified substantial underuse of coronary revascularization among patients who were considered appropriate candidates for these procedures. Underuse was associated with adverse clinical outcomes. (N Engl J Med 2001;344:645-54.) Copyright (C) 2001 Massachusetts Medical Society

Probing the Dawn of Galaxies at z~9-12: New Constraints from HUDF12/XDF and CANDELS Data

We present a comprehensive analysis of z>8 galaxies based on ultra-deep WFC3/IR data. We constrain the evolution of the UV luminosity function (LF) and luminosity densities from z~11 to z~8 by exploiting all the WFC3/IR data over the Hubble Ultra-Deep Field from the HUDF09 and the new HUDF12 program, in addition to the HUDF09 parallel field data, as well as wider area WFC3/IR imaging over GOODS-South. Galaxies are selected based on the Lyman Break Technique in three samples centered around z~9, z~10 and z~11, with seven z~9 galaxy candidates, and one each at z~10 and z~11. We confirm a new z~10 candidate (with z=9.8+-0.6) that was not convincingly identified in our first z~10 sample. The deeper data over the HUDF confirms all our previous z>~7.5 candidates as genuine high-redshift candidates, and extends our samples to higher redshift and fainter limits (H_160~29.8 mag). We perform one of the first estimates of the z~9 UV LF and improve our previous constraints at z~10. Extrapolating the lower redshift UV LF evolution should have revealed 17 z~9 and 9 z~10 sources, i.e., a factor ~3x and 9x larger than observed. The inferred star-formation rate density (SFRD) in galaxies above 0.7 M_sun/yr decreases by 0.6+-0.2 dex from z~8 to z~9, in good agreement with previous estimates. The low number of sources found at z>8 is consistent with a very rapid build-up of galaxies across z~10 to z~8. From a combination of all current measurements, we find a best estimate of a factor 10x decrease in the SFRD from z~8 to z~10, following (1+z)^(-11.4+-3.1). Our measurements thus confirm our previous finding of an accelerated evolution beyond z~8, and signify a rapid build-up of galaxies with M_UV<-17.7 within only ~200 Myr from z~10 to z~8, in the heart of cosmic reionization.Comment: 21 pages, 13 figures, 6 tables; submitted to Ap