Glomerulonephritis in schistosomiasis with mesangial IgM deposits

Twenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis.<br>Com o objetivo de observar as lesões renais iniciais na esquistossomose mansoni, foram selecionados 21 casos da forma hepato-esplênica, com idade média de 12 anos e que não apresentavam sinais clínicos ou laboratoriais de alterações renais. As biópsias foram realizadas durante esplenectomia e em seguida examinadas à microscopia ótica e à microscopia de fluorescência, sendo empregados conjugados anti IgG, IgM, IgA e C3, isoladamente. No exame microscópico, os 21 casos foram classificados em: 6 casos normais; 6 casos com lesões glomerulares consideradas mínimas e 9 casos com lesões mesangiais discretas ou moderadas. À imunofluorescência constatou-se presença de depósitos de IgM e de C3 predominantemente de localização mesangial, tanto nos casos de lesões mínimas, como nos casos de proliferação mesangial mais acentuada (Tabelas II e III). Constatou-se aind a depósitos de IgG em todos os casos, mesmo naqueles considerados normais, sendo entretanto localizados na parede capilar. Os autores acreditam que na esquistossomose mansoni as lesões glomerulares são provavelmente provocadas pela deposição inicial de imunoglobulinas M, formando imunocomplexos ligados a C3. A presença de IgG no mesangio, já descrita nos estágios mais avançados da glomerulopatia esquistossomótica, seria resultante de uma seqüência evolutiva

Schistosoma mansoni: structural damage after treatment with oxamniquine

The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed

High rates of unprotected receptive anal intercourse and their correlates among young and older MSM in Brazil

Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, of the Secretariat for Health Surveillance of the Brazilian Ministry of HealthUniversidade Federal de São João del-Rei. Divinopolis, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Medicina Preventiva e Social. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhaes. Recife, PE, Brazil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Faculdade de Ciências Medicas Santa Casa de São Paulo. São Paulo, SP, Brazil.Universidade do Estado Bahia. Departamento de Ciências da Vida. Salvador, BA, Brazil.Tulane University. School of Public Health and Tropical Medicine. New Orleans, LA, USA / Universidade Federal do Ceara. Dept Community Hlth. Fortaleza, CE, Brazil.Universidade Federal do Ceara. Dept Community Hlth. Fortaleza, CE, Brazil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Alfredo Mata. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Recife, PE, Brazil.Fundação Oswaldo Cruz. Recife, PE, Brazil.Fundação Oswaldo Cruz. Campo Grande, MS, Brazil / Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brazil.Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil.Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil.Universidade de Brasilia. Brasilia, DF, Brazil.Universidade de Brasilia. Brasilia, DF, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Faculdade de Ciências Medicas Santa Casa de São Paulo. São Paulo, SP, Brazil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal do Ceara. Project PI. Fortaleza, CE, Brazil.Centro Universitário Autônomo do Brasil. Curitiba, PR, Brazil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Universidade Federal do Ceara. Fortaleza, CE, Brazil.Universidade Federal do Ceara. Fortaleza, CE, Brazil.Secretaria Saúde Ceará. Fortaleza, CE, Brazil.Tulane University. New Orleans, LA, USA / Universidade Federal do Ceara. Fortaleza, CE, Brazil.University of California San Francisco. San Francisco, CA, USA.University of California San Francisco. San Francisco, CA, USA.Ministério da Saúde. Departamento de Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasilia, DF, Brazil.Ministério da Saúde. Departamento de Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasilia, DF, Brazil.Ministério da Saúde. Departamento de Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasilia, DF, Brazil.The aim of this study was to estimate the prevalence and factors associated with unprotected receptive anal intercourse (URAI), stratified by age (18-24 or 25 + years old), in a sample of 4,129 MSM recruited by respondent driven sampling in 12 Brazilian cities in 2016. The prevalence of URAI was higher among younger MSM (41.9% vs 29.7%) (p < 0.01). Multivariate analysis indicated that perception of risk, sexual identity, self-rated health status, and having commercial sex were associated with URAI among younger MSM. History of sexual violence, sex with younger partners, having 6 + partners and unprotected sexual debut were associated with URAI among older MSM. Marital status, having stable partner, and reporting sex with men only were associated with URAI in both groups. Despite access to condoms and lubricants, preventive efforts may not be reaching MSM effectively. Age specific intervention approaches, including stigma, discrimination, and perception of risk must be considered