La stima dei benefici del traffico divertito

In alcuni paesi europei (ad esempio Italia, Francia) è prassi comune, nella valutazione dei progetti di trasporto pubblico, stimare i benefici per gli utenti che passano da un modo di trasporto all’altro come la differenza tra il costo generalizzato del modo originale e quello del nuovo modo. In questo paper si sottolinea che tale metodologia di stima è scorretta e si punta ad aprire un dibattito sulla questione. Dato l’uso diffuso dei questa metodologia, la questione sollevata ha conseguenze significative in termini di policy, soprattutto perché gli investimenti in progetti di trasporto pubblico possono in realtà generare benefici per gli utenti sostanzialmente inferiori rispetto a quelli stimati, e quindi la loro giustificazione in termini di benessere può essere messa in discussione

Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches

The inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway is defined as homologous recombination deficiency (HRD). This molecular phenotype represents a positive predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors and platinum-based chemotherapy in ovarian cancers. However, HRD is a complex genomic signature, and different methods of analysis have been developed to introduce HRD testing in the clinical setting. This review describes the technical aspects and challenges related to HRD testing in ovarian cancer and outlines the potential pitfalls and challenges that can be encountered in HRD diagnostics

Cicerón y su drama político

Ante

Fotografía Personal.

Escritor italiano

Cleopatra contro Roma. Milano, Aldo Martello, (1963). 8, XV-316 p., pli., portrn.

OPLADEN-RUG0

'We are not afraid to die’: gender dynamics of agrarian change in Ratanakiri province, Cambodia

Dramatic changes have subverted the socially, culturally and resource-rich systems of indigenous communities living in Ratanakiri province. These changes include the incursion of market-based economy and commodification of land, the alienation of land and natural resources by way of economic land concessions (ELCs) and the inflow of large number of migrants from other regions and countries. Their cumulative impact has affected indigenous communities’ agrarian practices, their livelihoods and their system of beliefs and way of life, with important repercussions on social differentiation and gender relations. Based on fieldwork carried out in Ratanakiri province, this contribution analyses how emerging capitalist relations are shaping shifting gender relations and creating hierarchies of power that risk marginalising indigenous women and girls and eroding spaces of recognition, autonomy and agency they once had