Weighted sum formula for variants of half multiple zeta values

We prove some weighted sum formulas for half multiple zeta values, half finite multiple zeta values, and half symmetric multiple zeta values. The key point of our proof is Dougall's identity for the generalized hypergeometric function ${}_{5}F_{4}$. Similar results for interpolated refined symmetric multiple zeta values and half refined symmetric multiple zeta values are also discussed.Comment: 19 page

Compensación laboral y recompensas organizacionales a los trabajadores del Gobierno Regional del Callao - 2016

Este trabajo de investigación tiene con título: “Compensación laboral y recompensas organizacionales a los trabajadores del Gobierno Regional del Callao – 2016.”. La finalidad fue determinar si existe relación entre la compensación laboral y las recompensas organizacionales a los trabajadores del Gobierno regional del Callao 2016. El nivel de la investigación es descriptiva correlacional y el tipo de investigación es básica, además el tipo de diseño es no experimental transversal correlacional. Se aplicó una encuesta tipo Likert, a una muestra representativa de 90 trabajadores del Gobierno regional del Callao. La información de las encuestas fueron procesadas por el software SPSS v.21 . Las conclusiones son: (a) La remuneración básica se encuentra en un nivel intermedio en el Gobierno regional del Callao de acuerdo con la percepción mayoritaria de 44 trabajadores que representan el 48.90%. (b) Los incentivos salariales se encuentran en un nivel bajo en el Gobierno regional del Callao de acuerdo con la percepción mayoritaria de 38 trabajadores que representan el 42.20%. (c) Las prestaciones se encuentran en un nivel bajo en el gobierno regional del Callao de acuerdo con la percepción mayoritaria de 44 trabajadores que representan el 48.90%

Prostaglandin D2 synthase induces apoptosis in pig kidney LLC-PK1 cells

Prostaglandin D2 synthase induces apoptosis in pig kidney LLC-PK1 cells.BackgroundProstaglandin D2 synthase (PGD2S), a unique member of the lipocalin family, is found at elevated levels in the serum of patients with renal impairment and has recently been implicated as a new biochemical marker of renal insufficiency. The aim of this study was to investigate the apoptotic effects of PGD2S on a pig kidney epithelial cell line (LLC-PK1) and to investigate the effects of prostaglandins and growth factors on this process.MethodsApoptosis was detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL), annexin V staining, and electron microscopy.ResultsA four- to fivefold increase in apoptosis was observed in PGD2S-treated cells as compared with controls and the apoptosis appeared to act via caspase-3. A cyclooxygenase-2 inhibitor, anti-PGD2S antibody, and selenium all significantly inhibited the apoptosis induced by PGD2S; however, none had any effect on the apoptosis induced by the known apoptotic inducer camptothecin. Furthermore, prostaglandins E1 and E2, known to induce mitogen-activated protein (MAP) kinase phosphorylation and exhibit cytoprotective effects, both inhibited PGD2S-induced apoptosis, while prostaglandin H2 had no significant effect. Growth factors such as insulin, insulin-like growth factor-1, and platelet-derived growth factor also decreased PGD2S-induced apoptosis. In addition, PGD2S isolated from human serum seemed slightly more effective at inducing apoptosis than recombinantly expressed protein.ConclusionsWe report on the induction of apoptosis by PGD2S in LLC-PK1 pig kidney epithelial cells, and speculate that the accumulation of PGD2S in the serum of kidney failure patients may further exacerbate renal problems and is most likely regulated by other prostaglandins and growth factors

Metodología scrum y su incidencia en la gestión de proyectos en una empresa constructora, Lima 2022

El presente trabajo de investigación tuvo como objetivo general, determinar la incidencia de la metodología scrum en la gestión de proyectos en una empresa constructora, Lima 2022; para su desarrollo se utilizó el tipo de investigación básica, de diseño no experimental de nivel correlacional causal. La población y muestra de estudio estuvieron conformadas por un total de 70 trabajadores pertenecientes a una empresa constructora, la técnica utilizada para la recolección de datos fue la encuesta y el instrumento utilizado fue el cuestionario. A través de un análisis descriptivo e inferencial se obtuvo el resultado del R2 de Nagelkerke el cual fue de 0.385, cuya representación en porcentaje es de 38.5%, siendo esta la incidencia de la variable metodología scrum sobre la variable gestión de proyectos. Asimismo, este valor indica que la relación presente entre la variable metodología scrum y la variable gestión de proyectos es débil, esto se debe a que el valor obtenido de R2 de Nagelkerke está ubicado entre 0.26 y 0.50. Finalmente se concluye que la metodología scrum incide en la gestión de proyectos en una empresa constructora, Lima 2022, esto se debe al valor de incidencia de 38.5%

Random perturbation of sparse graphs

In the model of randomly perturbed graphs we consider the union of a deterministic graph Gα with minimum degree αn and the binomial random graph G(n, p). This model was introduced by Bohman, Frieze, and Martin and for Hamilton cycles their result bridges the gap between Dirac’s theorem and the results by Pósa and Korshunov on the threshold in G(n, p). In this note we extend this result in Gα ∪G(n, p) to sparser graphs with α = o(1). More precisely, for any ε > 0 and α: N ↦→ (0, 1) we show that a.a.s. Gα ∪ G(n, β/n) is Hamiltonian, where β = −(6 + ε) log(α). If α > 0 is a fixed constant this gives the aforementioned result by Bohman, Frieze, and Martin and if α = O(1/n) the random part G(n, p) is sufficient for a Hamilton cycle. We also discuss embeddings of bounded degree trees and other spanning structures in this model, which lead to interesting questions on almost spanning embeddings into G(n, p)

Differentiating SIADH from Cerebral/Renal Salt Wasting: Failure of the Volume Approach and Need for a New Approach to Hyponatremia

Hyponatremia is the most common electrolyte abnormality. Its diagnostic and therapeutic approaches are in a state of flux. It is evident that hyponatremic patients are symptomatic with a potential for serious consequences at sodium levels that were once considered trivial. The recommendation to treat virtually all hyponatremics exposes the need to resolve the diagnostic and therapeutic dilemma of deciding whether to water restrict a patient with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or administer salt and water to a renal salt waster. In this review, we briefly discuss the pathophysiology of SIADH and renal salt wasting (RSW), and the difficulty in differentiating SIADH from RSW, and review the origin of the perceived rarity of RSW, as well as the value of determining fractional excretion of urate (FEurate) in differentiating both syndromes, the high prevalence of RSW which highlights the inadequacy of the volume approach to hyponatremia, the importance of changing cerebral salt wasting to RSW, and the proposal to eliminate reset osmostat as a subtype of SIADH, and finally propose a new algorithm to replace the outmoded volume approach by highlighting FEurate. This algorithm eliminates the need to assess the volume status with less reliance on determining urine sodium concentration, plasma renin, aldosterone and atrial/brain natriuretic peptide or the BUN to creatinine ratio