超伝導素子を応用したX線検出器

X線領域の光子のエネルギー分散型検出において、エネルギー分解能と感度を高くするために超伝導素子が利用される。本稿では、超伝導トンネル接合（STJ）X線検出器と超伝導相転移端温度計（TES）型マイクロカロリーメータを紹介する。Superconducting devices are utilized for improving energy resolution and sensitivity in an energy-dispersive detection of X-ray photons. This article describes X-ray detectors by using superconducting tunnel junctions (STJs) and superconducting phase transition edge sensors

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear. Here, we found that pou5f3 mRNA encoding a transcriptional factor essential for development formed granules in a dormant state in zebrafish oocytes. Although the number of pou5f3 granules remained constant, Pou5f3 protein accumulated after fertilization. Intriguingly, signals of newly synthesized peptides and a ribosomal protein became colocalized with pou5f3 granules after fertilization and, moreover, nascent Pou5f3 was shown to be synthesized in the granules. This functional change was accompanied by changes in the state and internal structure of granules. Dissolution of the granules reduced the rate of protein synthesis. Similarly, nanog and sox19b mRNAs in zebrafish and Pou5f1/Oct4 mRNA in mouse assembled into granules. Our results reveal that subcellular compartments, termed embryonic RNA granules, function as activation sites of translation after changing physical properties for directing vertebrate development

Thin cathode glass gas electron multiplier detector for carbon beam dose imaging

An optically read-out glass gas electron multiplier (G-GEM) detector is expected to simplify complicated quality assurance measurements for hadron therapies by imaging the dose distribution of the incident beam. However, the effect of secondary particles from the detector itself has not been well studied. In this paper, we evaluate a design that reduces the secondary particles from the cathode of a G-GEM detector. Specifically, we assembled detectors with thin cathodes and assessed their effect on the secondary particle production in simulations and experiments. The experiments were carried out under 290 MeV/u 12C ion bombardment at the Heavy Ion Medical Accelerator in Chiba. The clinical intensity of the thin cathode detector was compared with that of a conventional thick cathode G-GEM detector. The improved chamber design reduced the dose contributions of secondary particles from the cathode without degrading the dose imaging performance

Updates in the Field of Submucosal Endoscopy

Submucosal endoscopy (third-space endoscopy) can be defined as an endoscopic procedure performed in the submucosal space. This procedure is novel and has been utilized for delivery to the submucosal space in a variety of gastrointestinal diseases, such as a tumor, achalasia, gastroparesis, and subepithelial tumors. The main submucosal endoscopy includes peroral endoscopic myotomy, gastric peroral endoscopic myotomy, Zenker peroral endoscopic myotomy, submucosal tunneling for endoscopic resection, and endoscopic submucosal tunnel dissection. Submucosal endoscopy has been used as a viable alternative to surgical techniques because it is minimally invasive in the treatment and diagnosis of gastrointestinal diseases and disorders. However, there is limited evidence to prove this. This article reviews the current applications and evidence regarding submucosal endoscopy while exploring the possible future clinical applications in this field. As our understanding of these procedures improves, the future of submucosal endoscopy could be promising in the fields of diagnostic and therapeutic endoscopy

Development and characterization of optical readout well-type glass gas electron multiplier for dose imaging in clinical carbon beams

The use of carbon ion beams in cancer therapy (also known as hadron therapy) is steadily growing worldwide; therefore, the demand for more efficient dosimetry systems is also increasing because daily quality assurance (QA) measurements of hadron radiotherapy is one of the most complex and time consuming tasks. The aim of this study is to develop a two-dimensional dosimetry system that offers high spatial resolution, a large field of view, quick data response, and a linear dose–response relationship.We demonstrate the dose imaging performance of a novel digital dose imager using carbon ion beams for hadron therapy. The dose imager is based on a newly-developed gaseous detector, a well-type glass gas electron multiplier. The imager is successfully operated in a hadron therapy facility with clinical intensity beams for radiotherapy. It features a high spatial resolution of less than 1 mm and an almost linear dose–response relationship with no saturation and very low linear-energy-transfer dependence. Experimental results show that the dose imager has the potential to improve dosimetry accuracy for daily QA