STRUCTURE AND VASCULARIZATION OF THE PERICARDIUM AND EPICARDIUM IN MAN

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COMPARATIVE STUDIES OF THE LIPIDS AND ACID MUCOPOLYSACCHARIDES IN THE WALL OF AORTA AND PULMONARY TRUNK IN EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

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VASCULARIZATION OF THE UPPER LIMB ARTERIES

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REGULARITIES OF THE VASCULARIZATION OF HUMAN ARTERIAL VESSELS

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The Bonebridge system – Our clinical experience /Case report/

Introduction: Bone conduction implants are a standard treatment option for patients with conductive or mixed, hearing loss. The Bonebridge system was introduced by MED-EL in 2012, and two years after its debut, it was used in more than 200 centers worldwide (6). For the first time the Bonebridge system was implanted in Bulgaria in 2015 by associated professor P. Rouev. The main audiological criteria for placement is conductive hearing loss, which is caused by atresia of the auditory canal or diseases of the middle ear with preserved bone conduction (below 45 dB), as well as unilateral hearing loss above 70 dB (contralateral hearing loss not more than 20 dB). The system does not penetrate the skin and consists of an internal part - an implant, which is placed completely under the skin, and an external part - a processor. The acoustic signal from the environment is transformed into mechanical vibrations that are transmitted to the mastoid bone. The expected results are an improved hearing threshold and better hearing in noisy environments.Methods: Our clinical experience with the Bonebridge system is based on three operated patients aged between 56 and 73 years. All three patients had evidence of bilateral conductive hearing loss. Here we present one of these cases.Results: Test results showed significant improvement in hearing sensitivity especially in frequencies round 1000 Hz.Conclusions: Bone conduction implants such as the Bonebridge system are an excellent treatment option for patients with bilateral conductive deafness. Bonebridge has good hearing results, relative simplicity, and low rate of complications. Experience has shown that the Bonebridge system is easy to use and highly reliable. The use of Bonebridge conduction implant system leads to a significant improvement in the quality of life

The Effect of Low Corporate Tax Rate on Payroll Tax Evasion

It is a commonly held view that the widespread policy of cutting the corporate income tax has a positive effect on taxable income through decreasing firms' incentive to hide profits. A neglected side of this policy, however, is its potential to trigger more evasion in other tax bases, such as the social security base, especially if the corporate income tax rate is low compared to the payroll rate. We develop a model in which employers and employees cooperate in declaring lower wages to the tax authorities in order to evade payroll contributions

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory pathway-resident and extracellular matrix proteins. However, its cell-type specific functions in vivo are still largely unknown. Therefore, we generated mice lacking the VLK gene (protein kinase domain containing, cytoplasmic (Pkdcc)) in mesenchymal cells. Most of the homozygous mice died shortly after birth, most likely as a consequence of their lung abnormalities and consequent respiratory failure. E18.5 embryonic lungs showed a reduction of alveolar type II cells, smaller bronchi, and an increased lung tissue density. Global mass spectrometry-based quantitative proteomics identified 97 proteins with significantly and at least 1.5-fold differential abundance between genotypes. Twenty-five of these had been assigned to the extracellular region and 15 to the mouse matrisome. Specifically, fibromodulin and matrilin-4, which are involved in extracellular matrix organization, were significantly more abundant in lungs from Pkdcc knockout embryos. These results support a role for mesenchyme-derived VLK in lung development through regulation of matrix dynamics and the resulting modulation of alveolar epithelial cell differentiation.ISSN:1420-682XISSN:1420-907