53 research outputs found
Associação da pressão arterial diastólica com o tempo acumulado de trabalho entre motoristas e cobradores
Modelagem estatística para estimação da população de protozoários ruminais em função da relação volumoso: concentrado na dieta e da presença de aditivos
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters
A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputations. We performed a multi-trait analysis of ONH parameters cup area, disc area and vertical cup-disc ratio. We uncover new variants; rs11158547 in PPP1R36-PLEKHG3 and rs1028727 near SERPINE3 at genome-wide significance that replicate in independent Asian cohorts imputed to 1000 Genomes. At this point, validation of these variants in POAG cohorts is hampered by the high degree of heterogeneity. Our results show that multi-trait analysis is a valid approach to identify novel pleiotropic variants for ONH
Simulation of the Vacuum Infusion Process using Idealized Components: Effects of Pore Size and Suspension Concentration
Surface changes in the anaesthetic conjunctiva in man, with special reference to the production of mucus from a non-goblet-cell source.
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