10 research outputs found
Biometric variability of goat populations revealed by means of principal component analysis
Associação entre fatores de risco cardiovascular e indicadores antropométricos de obesidade em universitários de São LuÃs, Maranhão, Brasil
Genetic diversity between herds of Alpine and Saanen dairy goats and the naturalized Brazilian Moxotó breed
Brazilian naturalized goat breeds are adapted to the semiarid conditions prevalent in the Northeast region of the country (which has the largest Brazilian goat heard) and represent an as yet uninvestigated source of genetic diversity. Currently, imported goat breeds are crossed with Brazilian naturalized goat breeds, endangering the genetic potential of the naturalized breeds. We used 11 microsatellite markers to determine the genetic diversity among imported (non-naturalized) dairy Alpine and Saanen goats and naturalized Brazilian Moxotó goats. We genotyped 292 goats from three herds (one private, one from the University of Minas Gerais and the Moxotó conservation herd from Embrapa Caprinos) and found that the general heterozygosity was 0.6952 for Alpine, 0.7043 for Saanen and 0.4984 for Moxotó goats. The number of alleles ranged from 5 (INRA005) to 11 (BM3205), with an average of 7 alleles per locus in the imported breeds and 3.5 alleles per locus in the Moxotó breed. Mean differentiation between populations was higher for herds (F ST S = 0.0768) than for breeds (F ST P = 0.0263), indicating similarity between the imported breeds and the existence of crosses between them. Nei's genetic distance was highest between the Moxotó breed and the imported breeds. These indicate that further studies using these molecular markers would be fruitful
Familial STAG2 germline mutation defines a new human cohesinopathy
We characterize a novel human cohesinopathy originated from a familial germline mutation of the gene encoding the cohesin subunit STAG2, which we propose to call STAG2-related X-linked Intellectual Deficiency. Five individuals carry a STAG2 p.Ser327Asn (c.980 G > A) variant that perfectly cosegregates with a phenotype of syndromic mental retardation in a characteristic X-linked recessive pattern. Although patient-derived cells did not show overt sister-chromatid cohesion defects, they exhibited altered cell cycle profiles and gene expression patterns that were consistent with cohesin deficiency. The protein level of STAG2 in patient cells was normal. Interestingly, STAG2 S327 is located at a conserved site crucial for binding to SCC1 and cohesin regulators. When expressed in human cells, the STAG2 p.Ser327Asn mutant is defective in binding to SCC1 and other cohesin subunits and regulators. Thus, decreased amount of intact cohesin likely underlies the phenotypes of STAG2-SXLID. Intriguingly, recombinant STAG2 p.Ser327Asn binds normally to SCC1, WAPL, and SGO1 in vitro, suggesting the existence of unknown in vivo mechanisms that regulate the interaction between STAG2 and SCC1
Soroprevalência de Toxoplasma gondii em rebanhos caprinos no Estado de São Paulo Seroprevalence of Toxoplasma gondii in dairy goats in the São Paulo State, Brazil
Foi colhido um total de 442 soros em rebanhos caprinos de sete regiões do Estado de São Paulo e testados para anticorpos contra Toxoplasma gondii pela reação de imunofluorescência indireta. Em todos os rebanhos, foram encontrados caprinos reagentes, totalizando 64 (14,5%) animais com sorologia positiva em diferentes capris.<br>Four hundred forty-two serum samples were collected from dairy goats in seven regions of São Paulo State. These were tested for Toxoplasma gondii antibodies using the indirect immunofluorescent antibody test. Sixty-four (14,5%) serologically positive animals were found from all these goat farms studied
CLINICAL, HEMATOLOGICAL, AND SEMINAL ALTERATIONS AND PARASITEMIA OF MALE GOATS EXPERIMENTALLY INFECTED WITH <italic>Toxoplasma gondii</italic>
Incorporação das ciências sociais na produção de conhecimentos sobre trabalho e saúde Incorporation of the social sciences in the production of knowledge about work and health
Este artigo apresenta uma revisão bibliográfica sobre a influência das ciências sociais para a superação de concepções reducionistas de relação trabalho-saúde, nas duas últimas décadas. Trata-se de um tipo de diagnóstico da produção cientÃfica, no qual destacam-se: as contribuições para a caracterização da saúde do trabalhador, como campo de conhecimento e de intervenção, e para a análise da polÃtica e das práticas das instituições públicas; as abordagens compreensivas e as questões de gênero. Efetuou-se um levantamento de artigos de periódicos indexados e de dissertações e teses de pós-graduação. Foram consultados: o banco de dissertações e teses da Coordenação de Aperfeiçoamento do Ensino Superior e do Instituto Brasileiro de Informação em Ciência e Tecnologia; a Biblioteca Virtual em Saúde da Biblioteca Regional de Medicina e o site do Scientific Electronic Library On-line. Constatou-se a predominância de estudos sobre temáticas especÃficas e determinadas categorias de trabalhadores, em contraposição a tentativas de abordagens totalizadoras. Apesar dos notáveis avanços em termos de conhecimento, existe carência significativa de investigações sobre segmentos da população trabalhadora que apresentam maior vulnerabilidade social.<br>This article presents a bibliographical revision on the influence of the social sciences to overcome the reducing conceptions of relationship work-health, in the last two decades. It is a type of diagnosis of the scientific production, in which outstanding aspects are: the contributions for the characterization of the worker’s health, as knowledge field and of intervention, and for the analysis of the politics and of the practices of the public institutions; the comprehensive approaches and gender questions. It was conducted an assessment of indexed journals and masters degree dissertations and doctoral thesis. It was consulted: the bank of dissertations and thesis organized by the Coordination of Improvement of the Higher Education and for the Brazilian Institute of Information in Science and Technology; the Virtual Library in Health of the Regional Library of Medicine and Scientific Electronic site On-line Library. It was verified the predominance of studies on specific themes and certain categories of workers, in opposition to attempts of totalizing approaches. In spite of the outstanding progresses in knowledge terms and of enlargement of study objects, significant lack of investigations exists on segments of the working population that present larger social vulnerability