Beetroot Juice Does Not Enhance Altitude Running Performance in Well-Trained Athletes

We hypothesized that acute dietary nitrate (NO3-) provided as concentrated beetroot juice supplement would improve endurance running performance of well-trained runners in normobaric hypoxia. Ten male runners (mean (SD): sea level V�O2max 66 (7) mL.kg^-1.min^-1, 10 km personal best 36 (2) min) completed incremental exercise to exhaustion at 4000 m and a 10 km treadmill time trial at 2500 m simulated altitude on separate days, after supplementation with ~7 mmol NO3- and a placebo, 2.5 h before exercise. Oxygen cost, arterial oxygen saturation, heart rate and ratings of perceived exertion (RPE) were determined during the incremental exercise test. Differences between treatments were determined using means [95% confidence intervals], paired sample t-tests and a probability of individual response analysis. NO3- supplementation increased plasma [nitrite] (NO3-, 473 (226) nM vs. placebo, 61 (37) nM, P < 0.001) but did not alter time to exhaustion during the incremental test (NO3-, 402 (80) s vs. placebo 393 (62) s, P = 0.5) or time to complete the 10 km time trial (NO3-, 2862 (233) s vs. placebo, 2874 (265) s, P = 0.6). Further, no practically meaningful beneficial effect on time trial performance was observed as the 11 [-60 to 38] s improvement was less than the a priori determined minimum important difference (51 s), and only three runners experienced a ´likely, probable´ performance improvement. NO3- also did not alter oxygen cost, arterial oxygen saturation, heart rate or RPE. Acute dietary NO3- supplementation did not consistently enhance running performance of well-trained athletes in normobaric hypoxia

Dynamics of the Compact, Ferromagnetic \nu=1 Edge

We consider the edge dynamics of a compact, fully spin polarized state at filling factor $\nu=1$. We show that there are two sets of collective excitations localized near the edge: the much studied, gapless, edge magnetoplasmon but also an additional edge spin wave that splits off below the bulk spin wave continuum. We show that both of these excitations can soften at finite wave-vectors as the potential confining the system is softened, thereby leading to edge reconstruction by spin texture or charge density wave formation. We note that a commonly employed model of the edge confining potential is non-generic in that it systematically underestimates the texturing instability.Comment: 13 pages, 7 figures, Revte

Edge reconstruction in the fractional quantum Hall regime

The interplay of electron-electron interaction and confining potential can lead to the reconstruction of fractional quantum Hall edges. We have performed exact diagonalization studies on microscopic models of fractional quantum Hall liquids, in finite size systems with disk geometry, and found numerical evidence of edge reconstruction under rather general conditions. In the present work we have taken into account effects like layer thickness and Landau level mixing, which are found to be of quantitative importance in edge physics. Due to edge reconstruction, additional nonchiral edge modes arise for both incompressible and compressible states. These additional modes couple to electromagnetic fields and thus can be detected in microwave conductivity measurements. They are also expected to affect the exponent of electron Green's function, which has been measured in tunneling experiments. We have studied in this work the electric dipole spectral function that is directly related to the microwave conductivity measurement. Our results are consistent with the enhanced microwave conductivity observed in experiments performed on samples with an array of antidots at low temperatures, and its suppression at higher temperatures. We also discuss the effects of the edge reconstruction on the single electron spectral function at the edge.Comment: 19 pages, 12 figure

String theory and the Kauffman polynomial

We propose a new, precise integrality conjecture for the colored Kauffman polynomial of knots and links inspired by large N dualities and the structure of topological string theory on orientifolds. According to this conjecture, the natural knot invariant in an unoriented theory involves both the colored Kauffman polynomial and the colored HOMFLY polynomial for composite representations, i.e. it involves the full HOMFLY skein of the annulus. The conjecture sheds new light on the relationship between the Kauffman and the HOMFLY polynomials, and it implies for example Rudolph's theorem. We provide various non-trivial tests of the conjecture and we sketch the string theory arguments that lead to it.Comment: 36 pages, many figures; references and examples added, typos corrected, final version to appear in CM

T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function

Innate lymphoid cells (ILCs) play an important role in regulating immune responses at mucosal surfaces. The transcription factor T-bet is crucial for the function of ILC1s and NCR+ ILC3s and constitutive deletion of T-bet prevents the development of these subsets. Lack of T-bet in the absence of an adaptive immune system causes microbiota-dependent colitis to occur due to aberrant ILC3 responses. Thus, T-bet expression in the innate immune system has been considered to dampen pathogenic immune responses. Here, we show that T-bet plays an unexpected role in negatively regulating innate type 2 responses, in the context of an otherwise intact immune system. Selective loss of T-bet in ILCs leads to the expansion and increased activity of ILC2s, which has a functionally important impact on mucosal immunity, including enhanced protection from Trichinella spiralis infection and inflammatory colitis. Mechanistically, we show that T-bet controls the intestinal ILC pool through regulation of IL-7 receptor signalling. These data demonstrate that T-bet expression in ILCs acts as the key transcriptional checkpoint in regulating pathogenic vs. protective mucosal immune responses, which has significant implications for the understanding of the pathogenesis of inflammatory bowel diseases and intestinal infections

Rotational and vibrational spectra of quantum rings

One can confine the two-dimensional electron gas in semiconductor heterostructures electrostatically or by etching techniques such that a small electron island is formed. These man-made ``artificial atoms'' provide the experimental realization of a text-book example of many-particle physics: a finite number of quantum particles in a trap. Much effort was spent on making such "quantum dots" smaller and going from the mesoscopic to the quantum regime. Far-reaching analogies to the physics of atoms, nuclei or metal clusters were obvious from the very beginning: The concepts of shell structure and Hund's rules were found to apply -- just as in real atoms! In this Letter, we report the discovery that electrons confined in ring-shaped quantum dots form rather rigid molecules with antiferromagnetic order in the ground state. This can be seen best from an analysis of the rotational and vibrational excitations

D3-branes on the Coulomb branch and instantons

The relative coefficients of higher derivative interactions of the IIB effective action of the form C^4, (D F_5)^4, F_5^8, ... (where C is the Weyl tensor and F_5 is the five-form field strength) are motivated by supersymmetry arguments. It is shown that the classical supergravity solution for N parallel D3-branes is unaltered by this combination of terms. The non-vanishing of \zeroC^2 in this background (where \zero C is the background value of the Weyl tensor) leads to effective O(1/alpha') interactions, such as C^2 and Lambda^8 (where Lambda is the dilatino). These contain D-instanton contributions in addition to tree and one-loop terms. The near horizon limit of the N D3-brane system describes a multi-AdS_5xS^5 geometry that is dual to \calN=4 SU(N) Yang-Mills theory spontaneously broken to S(U(M_1)x...xU(M_r)). Here, the N D3-branes are grouped into r coincident bunches with M_r in each group, with M_r/N = m_r fixed as N goes to infinity. The boundary correlation function of eight Lambda's is constructed explicitly. The second part of the paper considers effects of a constrained instanton in this large-N Yang-Mills theory by an extension of the analysis of Dorey, Hollowood and Khoze of the one-instanton measure at finite N. This makes precise the correspondence with the supergravity D-instanton measure at leading order in the 1/N expansion. However, the duality between instanton-induced correlation functions in Yang-Mills theory and the dual supergravity is somewhat obscured by complications relating to the structure of constrained instantons.Comment: 30 pages, JHEP style. Typos corrected and minor clarifications adde

The Functional, Metabolic, and Anabolic Responses to Exercise Training in Renal Transplant and Hemodialysis Patients

BACKGROUND.: Exercise intolerance is common in hemodialysis (HD) and renal transplant (RTx) patients and is related to muscle weakness. Its pathogenesis may vary between these groups leading to a different response to exercise. The aim of the study was to compare intrinsic muscular parameters between HD and RTx patients and controls, and to assess the response to exercise training on exercise capacity and muscular structure and function in these groups. METHODS.: Quadriceps function (isokinetic dynamometry), body composition (dual-energy x-ray absorptiometry), and vastus lateralis muscle biopsies were analyzed before and after a 12-week lasting training-program in 35 RTx patients, 16 HD patients, and 21 healthy controls. RESULTS.: At baseline, myosin heavy chain (MyHC) isoform composition and enzyme activities were not different between the groups. VO2peak and muscle strength improved significantly and comparably over the training-period in RTx, HD patients and controls (ptime<0.05). The proportion of MyHC type I isoforms decreased (ptime<0.001) and type IIa MyHC isoforms increased (ptime<0.05). The 3-hydroxyacyl-CoA-dehydrogenase activity increased (ptime=0.052). Intrinsic muscular changes were not significantly different between groups. In the HD group, changes in lean body mass were significantly related to changes in muscle insulin-like growth factor (IGF)-II and IGF binding protein-3. CONCLUSIONS.: Abnormalities in metabolic enzyme activities or muscle fiber redistribution do not appear to be involved in muscle dysfunction in RTx and HD patients. Exercise training has comparable beneficial effects on functional and intrinsic muscular parameters in RTx patients, HD patients, and controls. In HD patients, the anabolic response to exercise training is related to changes in the muscle IGF system

Nonmonotonic inelastic tunneling spectra due to surface spin excitations in ferromagnetic junctions

The paper addresses inelastic spin-flip tunneling accompanied by surface spin excitations (magnons) in ferromagnetic junctions. The inelastic tunneling current is proportional to the magnon density of states which is energy-independent for the surface waves and, for this reason, cannot account for the bias-voltage dependence of the observed inelastic tunneling spectra. This paper shows that the bias-voltage dependence of the tunneling spectra can arise from the tunneling matrix elements of the electron-magnon interaction. These matrix elements are derived from the Coulomb exchange interaction using the itinerant-electron model of magnon-assisted tunneling. The results for the inelastic tunneling spectra, based on the nonequilibrium Green's function calculations, are presented for both parallel and antiparallel magnetizations in the ferromagnetic leads.Comment: 9 pages, 4 figures, version as publishe