Humanized mice: are we there yet?

Animal models have been instrumental in increasing the understanding of human physiology, particularly immunity. However, these animal models have been limited by practical considerations and genetic diversity. The creation of humanized mice that carry partial or complete human physiological systems may help overcome these obstacles. The National Institute of Allergy and Infectious Diseases convened a workshop on humanized mouse models for immunity in Bethesda, MD, on June 13–14, 2005, during which researchers discussed the benefits and limitations of existing animal models and offered insights into the development of future humanized mouse models

Induction of angiogenesis using VEGF releasing genipin-crosslinked electrospun gelatin mats

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Patient Safety and Risk Management in Mental Health

AbstractThis chapter will review the most common adverse events that happen in a psychiatric unit and the safety measures that are needed to decrease the risk of errors and adverse events. The adverse events and errors that may happen in a psychiatric unit are unique and will be examined in detail. This section will also highlight the role of staff members and patients in preventing or causing the error

L’abbazia benedettina di Santa Maria di Valdiponte a Montelabate in Umbria. Per un’archeologia dei cantieri

study started an investigation into the archeology of the largest construction sites that concerned the monastery. Given the limited availability of archival documents, the research was based both on the interpretation of the survey of the construction and the direct analysis of the artifact. Providing specific dating was not the aim pursued; in fact it was to highlight the constructive relations between some key interventions, which were not known until now or whose importance was not fully understood. In particular, the monastery and the remains of the original crypt, incorporated and re-used under the presbytery of the church, have been taken into account. Great changes have been identified in the East Wing of the monastery, where the original nucleus was formed by a first part of the bell tower and an adjacent room on the ground floor. In the west wing, besides highlighting many additions, a large space was brought to light covered by tympanum arches, which had been forgotten and was probably used as a refectory

Post-Intubation Tracheoesophageal Fistula with Posterior Glottic Web

Tracheoesophageal fistula (TEF) after prolonged intubation could present as chronic aspiration and could be mistaken as unilateral or bilateral vocal fold palsy, especially when there was combined posterior glottic synechia. We present a case of post-intubation TEF which was successfully treated with tracheal resection and anastomosis with primary esophageal closure. The accompanying posterior glottic web was treated by endoscopic technique of web lysis, with topical application of mitomycin C solution

Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135360/1/nyas13297.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135360/2/nyas13297_am.pd