Widening use of dexamethasone implant for the treatment of macular edema

Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of efficacy between injections with a good safety profile. Various other ocular pathologies with inflammatory etio­pathogeneses associated with macular edema have been treated by DEX implant, including neovascular age-related macular degeneration, Irvine–Gass syndrome, vasoproliferative retinal tumors, retinal telangiectasia, Coats’ disease, radiation maculopathy, retinitis pigmentosa, and macular edema secondary to scleral buckling and pars plana vitrectomy. We undertook a review to provide a comprehensive collection of all of the diseases that benefit from the use of the sustained-release DEX implant, alone or in combination with concomitant therapies. A MEDLINE search revealed lack of randomized controlled trials related to these indications. Therefore we included and analyzed all available studies (retrospective and prospective, com­parative and non-comparative, randomized and nonrandomized, single center and multicenter, and case report). There are reports in the literature of the use of DEX implant across a range of macular edema-related pathologies, with their clinical experience supporting the use of DEX implant on a case-by-case basis with the aim of improving patient outcomes in many macular pathologies. As many of the reported macular pathologies are difficult to treat, a new treat­ment option that has a beneficial influence on the clinical course of the disease may be useful in clinical practice

Efficient laser-overdense plasma coupling via surface plasma waves and steady magnetic field generation

International audienceThe efficiency of laser overdense plasma coupling via surface plasma wave excitation is investigated. Two-dimensional particle-in-cell simulations are performed over a wide range of laser pulse intensity from 10 15 to 10 20 W cm À2 lm 2 with electron density ranging from 25 to 100n c to describe the laser interaction with a grating target where a surface plasma wave excitation condition is fulfilled. The numerical studies confirm an efficient coupling with an enhancement of the laser absorption up to 75%. The simulations also show the presence of a localized, quasi-static magnetic field at the plasma surface. Two interaction regimes are identified for low (Ik 2 10 17 W cm À2 lm 2) laser pulse intensities. At " relativistic " laser intensity, steady magnetic fields as high as $580 MG lm/k 0 at 7 Â 10 19 W cm À2 lm 2 are obtained in the simulations

Enantiomerically pure phosphonated carbocyclic 2'-oxa-3'-azanucleosides: synthesis and biological evaluation

Starting from enantiomeric pure 1-[(3S,5R)- and 1-[(3R,5S)-3-(hydroxymethyl)-2-methylisoxazolidin-5-yl]-5-methylpyrimidine-2,4(1H,3H)-diones (-)7a and (+)7b, obtained by lipase-catalyzed resolution, pure diethyl{[(3S,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (-)12a and diethyl{[(3R,5S)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (+)12b have been synthesized. The obtained compounds showed no cytotoxic activity versus the U937 cell line in comparison with AZT, and were poorly able to inhibit HIV infection in vitro

Surface Oscillations in Overdense Plasmas Irradiated by Ultrashort Laser Pulses

The generation of electron surface oscillations in overdense plasmas irradiated at normal incidence by an intense laser pulse is investigated. Two-dimensional (2D) particle-in-cell simulations show a transition from a planar, electrostatic oscillation at $2\omega$, with $\omega$ the laser frequency, to a 2D electromagnetic oscillation at frequency $\omega$ and wavevector $k>\omega/c$. A new electron parametric instability, involving the decay of a 1D electrostatic oscillation into two surface waves, is introduced to explain the basic features of the 2D oscillations. This effect leads to the rippling of the plasma surface within a few laser cycles, and is likely to have a strong impact on laser interaction with solid targets.Comment: 9 pages (LaTeX, Revtex4), 4 GIF color figures, accepted for publication in Phys. Rev. Let

Continuous improvement planning through sustainability assessment of product-service systems

The paper presents a methodology for the integrated sustainability assessment of a product-service system lifecycle, with the purpose to support continuous improvement on the side both of the manufacturer and of the user. Its eight steps are an extension of ISO 14040 life cycle assessment and consider all three sustainability dimensions – economic, environmental and social – and a service perspective, using the service unit. A set of indicators for the three dimensions, aligned to the service unit concept, is proposed based on literature suggestions

Dynamics of charge-displacement channeling in intense laser-plasma interactions

The dynamics of transient electric fields generated by the interaction of high intensity laser pulses with underdense plasmas has been studied experimentally with the proton projection imaging technique. The formation of a charged channel, the propagation of its front edge and the late electric field evolution have been characterised with high temporal and spatial resolution. Particle-in-cell simulations and an electrostatic, ponderomotive model reproduce the experimental features and trace them back to the ponderomotive expulsion of electrons and the subsequent ion acceleration.Comment: 5 figures, accepted for publication in New Journal of Physic

Mean-Field Interacting Boson Random Point Fields in Weak Harmonic Traps

A model of the mean-field interacting boson gas trapped by a weak harmonic potential is considered by the \textit{boson random point fields} methods. We prove that in the Weak Harmonic Trap (WHT) limit there are two phases distinguished by the boson condensation and by a different behaviour of the local particle density. For chemical potentials less than a certain critical value, the resulting Random Point Field (RPF) coincides with the usual boson RPF, which corresponds to a non-interacting (ideal) boson gas. For the chemical potentials greater than the critical value, the boson RPF describes a divergent (local) density, which is due to \textit{localization} of the macroscopic number of condensed particles. Notice that it is this kind of transition that observed in experiments producing the Bose-Einstein Condensation in traps

Application of the Novel "emeritus" Air Cooled Condenser in Geothermal ORC

The present work aims to investigate the potential advantages in using a novel wet and dry configuration for heat rejection units in ORC power plants. The reference case is a geothermal power plant that exploits a medium temperature brine and uses a closed loop of cooling water to release the condensation heat. In the calculations, the off-design operation of the whole plant is optimized by a techno-economic point of view with a realistic part-load behaviour for the ORC and the use of experimentally validated correlations for the heat rejection section. The performance attainable with the novel LU-VE Emeritus® unit equipped with a water spray system and adiabatic panels is compared with those achievable with the same unit in dry operation. Final results show a marked increase of revenues with Emeritus® units with respect to a dry unit