32 research outputs found
Kinematics and physical conditions of HI in nearby radio sources. The last survey of the old Westerbork Synthesis Radio Telescope
We present an analysis of the properties of neutral hydrogen (HI) in 248
nearby (0.0230\log\,P_{\rm 1.4
\,GHz}=22.5^{-1}26.2^{-1}27\% \pm 5.5\%\log\,P_{\rm 1.4 \, GHz}>24^{-1}3.5\times 10^{17} (T_{ \rm
spin}/c_f)^{-2}$. We use our results to predict the number and type of HI
absorption lines that will be detected by the upcoming surveys of the Square
Kilometre Array precursors and pathfinders (Apertif, MeerKAT, and ASKAP).Comment: 22 pages, 15 figures, 4 tables, accepted for publication in A&
Regulation der Genexpression von MYCN in humanen Neuoblastomzellen durch Transkriptionsfaktoren der E2F-Familie
Seit fast 30 Jahren ist bekannt, dass die Amplifikation und Expression des Onkogens MYCN in Neuroblastomen mit einer sehr ungünstigen Prognose für die Patienten einhergeht. Dennoch liegen die Mechanismen der Genregulation von MYCN weiterhin größtenteils im Dunkeln.
Die Präsenz potentieller Bindungsstellen für E2F-Proteine im Promotor des MYCN-Gens sowie Zellkulturexperimente lieferten Hinweise auf eine Rolle der Transkriptionsfaktoren der E2F-Familie in der Regulation der N-myc-Expression.
Ziel dieser Arbeit war die Beantwortung der Frage, ob E2F-Proteine notwendig sind, um eine primär hohe Expression von N-myc in Neuroblastomzellen mit Amplifikation des Onkogens aufrechtzuerhalten, und ob sie hinreichend sind, um die Transkription von MYCN in Zellen ohne endogene Expression von N-myc einzuleiten.
Durch Überexpression des Tumorsuppressorproteins p16, welches zu einer Inaktivierung endogener E2F-Proteine führt, konnte die MYCN-mRNA-Menge in Neuroblastomzellen deutlich gesenkt werden. Vergleichbare Resultate wurden durch Expression von dominant negativem E2F-1 erzielt. Da in einigen Studien gezeigt werden konnte, dass Myc-Proteine ihrerseits E2F-Gene aktivieren können, nehmen wir an, in aggressiven Neuroblastomen könnte eine positive Rückkopplungsschleife zwischen E2F-Transkriptionsfaktoren auf der einen und N-myc auf der anderen Seite existieren, die die gesteigerte Aktivität des MYCN-Onkogens aufrechterhält.
Stabil transfizierte E2F-ER-Fusionsproteine waren jedoch nicht in der Lage, das endogene MYCN-Gen in Neuroblastomzellen ohne Expression von N-myc anzuschalten. E2F-Proteine werden folglich für das volle Ausmaß der starken Expression von N-myc in Neuroblastomen benötigt, sind aber nicht ausreichend, um das Onkogen MYCN in Zellen ohne endogenes N-myc zu aktivieren.
In der Zukunft könnte durch Verhinderung der Bindung von E2F-Proteinen an den MYCN-Promotor oder durch gentherapeutische Ansätze, die z.B. mittels viraler Infektion den Signalweg zwischen p16 und E2F rekonstruieren, die Expression von N-myc in Neuroblastomen gesenkt werden, so dass die Aggressivität der Tumore reduziert und die individuelle Prognose der Patienten verbessert werden könnte
AGN feeding and feedback in fornax a : kinematical analysis of the multi-phase ISM
We present a multi-wavelength study of the gaseous medium surrounding the nearby active galactic nucleus (AGN), Fornax A. Using MeerKAT, ALMA, and MUSE observations, we reveal a complex distribution of the atomic (H i), molecular (CO), and ionised gas in its centre and along the radio jets. By studying the multi-scale kinematics of the multi-phase gas, we reveal the presence of concurrent AGN feeding and feedback phenomena. Several clouds and an extended 3 kpc filament – perpendicular to the radio jets and the inner disk (r . 4:5 kpc) – show highly-turbulent kinematics, which likely induces non-linear condensation and subsequent chaotic cold accretion (CCA) onto the AGN. In the wake of the radio jets and in an external (r & 4:5 kpc) ring, we identify an entrained massive ( 107 M ) multi-phase outflow (vOUT 2000 km s1). The rapid flickering of the nuclear activity of Fornax A ( 3 Myr) and the gas experiencing turbulent condensation raining onto the AGN provide quantitative evidence that a recurrent, tight feeding and feedback cycle may be self-regulating the activity of Fornax A, in agreement with CCA simulations. To date, this is one of the most in-depth probes of such a mechanism, paving the way to apply these precise diagnostics to a larger sample of nearby AGN hosts and their multi-phase inter stellar medium.The European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme; Montage is funded by the National Science Foundation; the Department of Science and Technology and National Research Foundation.http://www.hanspub.org/Journal/AAS.htmlam2022Physic
CO(=1-0) mapping survey of 64 galaxies in the Fornax cluster with the ALMA Morita array
We conduct a CO(=1-0) (hereafter CO) mapping survey of 64
galaxies in the Fornax cluster using the ALMA Morita array in cycle 5. CO
emission is detected from 23 out of the 64 galaxies. Our sample includes dwarf,
spiral and elliptical galaxies with stellar masses of ~M. The achieved beam size and sensitivity are
and ~mJy~beam at the velocity resolution of
~km~s, respectively. We study the cold-gas (molecular- and
atomic-gas) properties of 38 subsamples with ~M
combined with literature HI data. We find that: (1) the low star-formation (SF)
activity in the Fornax galaxies is caused by the decrease in the cold-gas mass
fraction with respect to stellar mass (hereafter, gas fraction) rather than the
decrease of the SF efficiency from the cold gas; (2) the atomic-gas fraction is
more heavily reduced than the molecular-gas fraction of such galaxies with low
SF activity. A comparison between the cold-gas properties of the Fornax
galaxies and their environmental properties suggests that the atomic gas is
stripped tidally and by the ram pressure, which leads to the molecular gas
depletion with an aid of the strangulation and consequently SF quenching.
Pre-processes in the group environment would also play a role in reducing
cold-gas reservoirs in some Fornax galaxies.Comment: 53 pages, 41 figures, accepted for publication in ApJ
MeerKAT-16 H I observation of the dIrr galaxy WLM
We present observations and models of the kinematics and the distribution of
the neutral hydrogen (HI) in the isolated dwarf irregular galaxy,
Wolf-Lundmark-Melotte (WLM). We observed WLM with the Green Bank Telescope
(GBT) and as part of the MeerKAT Early Science Programme, where 16 dishes were
available. The HI disc of WLM extends out to a major axis diameter of 30 arcmin
(8.5 kpc), and a minor axis diameter of 20 arcmin (5.6 kpc) as measured by the
GBT. We use the MeerKAT data to model WLM using the TiRiFiC software suite,
allowing us to fit different tilted-ring models and select the one that best
matches the observation. Our final best-fitting model is a flat disc with a
vertical thickness, a constant inclination and dispersion, and a
radially-varying surface brightness with harmonic distortions. To simulate
bar-like motions, we include second-order harmonic distortions in velocity in
the tangential and the vertical directions. We present a model with only
circular motions included and a model with non-circular motions. The latter
describes the data better. Overall, the models reproduce the global
distribution and the kinematics of the gas, except for some faint emission at
the 2-sigma level. We model the mass distribution of WLM with a
pseudo-isothermal (ISO) and a Navarro-Frenk-White (NFW) dark matter halo
models. The NFW and the ISO models fit the derived rotation curves within the
formal errors, but with the ISO model giving better reduced chi-square values.
The mass distribution in WLM is dominated by dark matter at all radii.Comment: Accepted for publication in MNRAS, 25 pages, 21 figures, 5 table
GASP XXVI. HI gas in jellyfish galaxies : the case of JO201 and JO206
Please read abstract in the article.European
Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme grant agreement no. 679627 and no.833824,
project name FORNAX and GASP, respectively. We acknowledge funding from
the agreement ASI-INAF n.2017-14-H.0, as well as from the INAF main-stream
funding programme. M. R’s research is supported by the SARAO HCD programme
via the "New Scientific Frontiers with Precision Radio Interferometry"
research group grant. M. R. acknowledges support from the Italian Ministry
of Foreign A airs and International Cooperation (MAECI Grant Number
ZA18GR02) and the South African Department of Science and Technology’s
National Research Foundation (DST-NRF Grant Number 113121) as
part of the ISARP RADIOSKY2020 Joint Research Scheme. B. V. and M. G.
also acknowledge the Italian PRIN-Miur 2017 (PI A. Cimatti). Y. J. acknowledges
financial support from CONICYT PAI (Concurso Nacional de Insercion
en la Academia 2017), No. 79170132 and FONDECYT Iniciación 2018 No.
11180558. M. V. acknowledges support by the Netherlands Foundation for Scientific
Research (NWO) through VICI grant 016.130.338.http://www.aanda.orgam2020Physic
MeerKAT-16 HI observation of the dIrr galaxy WLM
We present observations and models of the kinematics and the distribution of the
neutral hydrogen (Hi) in the isolated dwarf irregular galaxy, Wolf-Lundmark-Melotte
(WLM). We observed WLM with the Green Bank Telescope (GBT) and as part of
the MeerKAT Early Science Programme, where 16 dishes were available. The Hi disc
of WLM extends out to a major axis diameter of 300 (8.5 kpc), and a minor axis
diameter of 200 (5.6 kpc) as measured by the GBT. We use the MeerKAT data to
model WLM using the TiRiFiC software suite, allowing us to t di erent tilted-ring
models and select the one that best matches the observation. Our nal best- tting
model is a
at disc with a vertical thickness, a constant inclination and dispersion,
and a radially-varying surface brightness with harmonic distortions. To simulate bar-
like motions, we include second-order harmonic distortions in velocity in the tangential
and the vertical directions. We present a model with only circular motions included
and a model with non-circular motions. The latter describes the data better. Overall,
the models reproduce the global distribution and the kinematics of the gas, except for
some faint emission at the 2 level. We model the mass distribution of WLM with a
pseudo-isothermal (ISO) and a Navarro-Frenk-White (NFW) dark matter halo models.
The NFW and the ISO models t the derived rotation curves within the formal errors,
but with the ISO model giving better reduced chi-square values. The mass distribution
in WLM is dominated by dark matter at all radii.The MeerKAT telescope is operated by the South African
Radio Astronomy Observatory, which is a facility of the Na-
tional Research Foundation, an agency of the Department
of Science and Innovation.
This work is based upon research supported by the South
African Research Chairs Initiative of the Department of Sci-
ence and Technology and National Research Foundation.
The nancial assistance of the South African Radio Astron-
omy Observatory (SARAO) towards this research is hereby
acknowledged (www.sarao.ac.za).
PK is partially supported by the BMBF project 05A17PC2
for D-MeerKAT.
AS acknowledges the Russian Science Foundation grant
19-12-00281 and the Program of development of M.V.http://mnras.oxfordjournals.orgam2021Physic
The extended H i halo of NGC 4945 as seen by MeerKAT
The State Agency for Research of the Spanish Ministry of Science, Innovation and Universities through the ‘Center of Excellence Severo Ochoa’ awarded to the Instituto de Astrofísica de Andalucía; the Economic Transformation, Industry, Knowledge and Universities Council of the Regional Government of Andalusia and the European Regional Development Fund from the European Union; the South African Radio Astronomy Observatory (SARAO); BMBF Verbundforschung; DFG Sonderforschungsbereich and the European Research Council (ERC).http://mnras.oxfordjournals.orghj2022Physic
The extended H I halo of NGC 4945 as seen by MeerKAT
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Observations of the neutral atomic hydrogen (H I) in the nuclear starburst galaxy NGC 4945 with MeerKAT are presented. We find a large amount of halo gas, previously missed by H I observations, accounting for 6.8 per cent of the total H I mass. This is most likely gas blown into the halo by star formation. Our maps go down to a 3σ column density level of 5 × 1018 cm−2. We model the H I distribution using tilted-ring fitting techniques and find a warp on the galaxy’s approaching and receding sides. The H I in the northern side of the galaxy appears to be suppressed. This may be the result of ionization by the starburst activity in the galaxy, as suggested by a previous study. The origin of the warp is unclear but could be due to past interactions or ram pressure stripping. Broad, asymmetric H I absorption lines extending throughout the H I emission velocity channels are present towards the nuclear region of NGC 4945. Such broad lines suggest the existence of a nuclear ring moving at a high circular velocity. This is supported by the clear rotation patterns in the H I absorption velocity field. The asymmetry of the absorption spectra can be caused by outflows or inflows of gas in the nuclear region of NGC 4945. The continuum map shows small extensions on both sides of the galaxy’s major axis that might be signs of outflows resulting from the starburst activity. © The Author(s) 2022. Published by Oxford University Press on behalf of Royal Astronomical Society.RI acknowledges financial support from grant RTI2018-096228-B-C31 (MCIU/AEI/FEDER,UE) and from the State Agency for Research of the Spanish Ministry of Science, Innovation and Universities through the ‘Center of Excellence Severo Ochoa’ awarded to the Instituto de Astrofísica de Andalucía (SEV-2017-0709), from the grant IAA4SKA (Ref. R18-RT-3082) from the Economic Transformation, Industry, Knowledge and Universities Council of the Regional Government of Andalusia and the European Regional Development Fund from the European Union. The MeerKAT telescope is operated by the South African Radio Astronomy Observatory, which is a facility of the National Research Foundation, an agency of the Department of Science and Innovation. This work is based upon research supported by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation. The financial assistance of the South African Radio Astronomy Observatory (SARAO) towards this research is hereby acknowledged (www.sarao.ac.za). At Ruhr University Bochum, this research is supported by BMBF Verbundforschung grant 05A20PC4 and by DFG Sonderforschungsbereich SFB1491. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme grant agreement no. 882793, project name MeerGas. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no.679627; project name FORNAX).Peer reviewe