899 research outputs found
The English Way to Italian Socialism: The PCI, âRed Bolognaâ and Italian Communist Culture as Seen through the English Prism
This contribution analyses the British perception of Red Bologna during the seventies and eighties, when politicians in the UK thought of Bolognese Social-Democrats as an example of good government. Maccaferri investigates the way in which the British political debate and the intellectual public discourse (as seen in journals, pamphlets and books) âimportedâ, deconstructed, adapted and appropriated the Italian communist model. The aim is to cast light on an âItaly Made in Britainâ that was constructed in the prevalently left-wing British political debate between the mid-nineteen seventies and the late nineteen-eighties, namely until Italian Communism started to search for a new name and a new identity, and, indeed, it liquidated the model itself. This article considers the debate expressed in the pamphlet Red Bologna (eds Max JĂ€ggi, Roger MĂŒller, Sil Schmid, 1977), journals such as Power and Politics and The New Left review, and newspapers such as The Guardian and The Observer. Furthermore, it focusses on the resurgence of leftist intellectuals. It deals primarily with Marxism Todayâs Italian discourse. By focusing on such a view, Maccaferri reconstructs the way in which, whilst engaging with the Thatcherite period, the English political debate and intellectual discourse perceived and constructed a very different kind of Italy that was simultaneously revolutionary and communist in its ideology and âmoderateâ and socialist â if not liberal â in its policies
Puffed Noncommutative Nonabelian Vortices
We present new solutions of noncommutative gauge theories in which coincident
unstable vortices expand into unstable circular shells. As the theories are
noncommutative, the naive definition of the locations of the vortices and
shells is gauge-dependent, and so we define and calculate the profiles of these
solutions using the gauge-invariant noncommutative Wilson lines introduced by
Gross and Nekrasov. We find that charge 2 vortex solutions are characterized by
two positions and a single nonnegative real number, which we demonstrate is the
radius of the shell. We find that the radius is identically zero in all
2-dimensional solutions. If one considers solutions that depend on an
additional commutative direction, then there are time-dependent solutions in
which the radius oscillates, resembling a braneworld description of a cyclic
universe. There are also smooth BIon-like space-dependent solutions in which
the shell expands to infinity, describing a vortex ending on a domain wall.Comment: 21 pages, 3 eps figures. v2: published version, analytic solution
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Nanoscale magnetophotonics
This Perspective surveys the state-of-the-art and future prospects of science
and technology employing the nanoconfined light (nanophotonics and
nanoplasmonics) in combination with magnetism. We denote this field broadly as
nanoscale magnetophotonics. We include a general introduction to the field and
describe the emerging magneto-optical effects in magnetoplasmonic and
magnetophotonic nanostructures supporting localized and propagating plasmons.
Special attention is given to magnetoplasmonic crystals with transverse
magnetization and the associated nanophotonic non-reciprocal effects, and to
magneto-optical effects in periodic arrays of nanostructures. We give also an
overview of the applications of these systems in biological and chemical
sensing, as well as in light polarization and phase control. We further review
the area of nonlinear magnetophotonics, the semiconductor spin-plasmonics, and
the general principles and applications of opto-magnetism and nano-optical
ultrafast control of magnetism and spintronics
Editorial: Advances in breeding for wheat disease resistance
Wheat is the most widely planted crop on the planet and contributes up to 20% of total calorie intake for humankind. Maintaining wheat yields is crucial to feeding the worldâs people, especially as climate models suggest that rising global temperatures will negatively affect wheat production (Asseng et al., 2015). Diseases of wheat take an important toll, annually robbing humanity of 20% or more of the crop on a global basis (Savary et al., 2019; Savary and Willocquet, 2021). Changes in weather patterns may accelerate pathogen life cycles and escalate shifts in pathogen populations and virulence, posing significant challenges to disease resistance breeding. As well, global trade may increase the chances for a pathogen to spread rapidly and adapt to novel environments and even hosts, leading to emerging diseases.
The release and use of wheat cultivars with effective and durable disease resistance is more important now than ever. This is so for multiple reasons. First, disease resistance stabilizes yields and reduces economic losses, saving money for producers who are already facing major challenges due to rising temperatures, more frequent and unpredictable natural disasters, and high and rising costs of inputs such as pesticides (FAO, 2021; LĂŒttringhaus et al., 2021; Miedaner and Juroszek, 2021). Second, greater reliance on disease resistance can slow pathogen spread and multiplication, prolonging the useful life of available pesticide chemistries so they will be effective when needed to manage severe epidemics (Brent et al., 2007). Third, the growing use of conservation tillage, which is vital for soil health and stabilization, has elevated the importance of diseases such as Fusarium head blight that cannot be completely managed with fungicides (Aboukhaddour et al., 2020).
Breeding for disease resistance in wheat has made major technological advances, but still faces important challenges. Prominent among those challenges is the need to develop cultivars for a tremendous diversity of agro-ecological environments, production practices, and discrete market classes (Cowger, 2021). Another challenge is that major genes such as those traditionally deployed to manage wheat rust diseases are often rapidly overcome. This requires a focus on quantitative and race non-specific resistance that may be harder to introgress, select for, and retain in a multi-trait context (Cowger and Brown, 2019; van Esse et al., 2020). The more genes are identified and their mechanisms of action elucidated, the more tools will be available to researchers and breeders to assemble genetically novel germplasm with improved and more durable resistance.
The authors who have contributed to this Research Topic tackle those challenges by providing new resources and tools to aid wheat breeders across the globe. The 18 original articles cover a good sample of the worldâs most important wheat diseases and the state-of-the-art techniques applied by researchers to identify and evaluate the relevant disease resistance traits. For example, wheat blast is an emergent and damaging disease that has jumped continents from Latin America to Asia, as explained in a comprehensive review by Singh et al., 2021. A team of blast researchers has compared marker-assisted and genomic selection using precision phenotyping of blast resistance conferred by the 2NS translocation (Juliana et al., 2022), which is partial and sometimes background-dependent.
Another major threat to global wheat production is Fusarium head blight. Three articles in this Research Topic offer important new resources for breeding cultivars with effective FHB resistance. The Brazilian spring cultivar Surpresa provides a new source of resistance not currently used (Poudel et al. 2022). Three resistance loci (Fhb1, Fhb4, and Fhb5) were introgressed as a pyramid into desirable Chinese white and red semi-winter wheat lines (Zhang et al., 2021). And a novel technique could speed up the development of FHB-resistant winter wheat germplasm, increasing breeding generations from two to three per year (Zakieh et al. 2021).
Researchers used various approaches to identify new sources of resistance to the three wheat rusts (stem, stripe, and leaf). A new stem rust resistance gene was mapped in the durum wheat variety Kronos and introgressed into common wheat using co-segregating DNA markers (Li et al., 2021). The effects of combinations of leaf rust resistance genes were investigated in a Canadian wheat double-haploid population (McCallum and Hiebert, 2022) and in a durably resistant Canadian wheat cultivar (Bokore et al., 2022). A multi-parent advanced generation intercross (MAGIC) wheat population was used to map adult-plant and seedling resistance to stripe rust in Germany (Rollar et al., 2021). A genome-wide association study was used to identify stripe rust resistance loci in a panel of Chinese wheat landraces (Yao et al., 2021). And QTL mapping led to identification of stripe and leaf rust loci in an Afghan landrace (Zhang et al., 2022), a Chinese landrace (Wang et al., 2022), and the CIMMYT wheat line âMucuyâ (Lan et al., 2022; so far this is an abstract, need the URL to the full article when itâs available).
Breeding wheat cultivars with resistance to powdery mildew requires a constant stream of new resistance sources, thanks to the pathogenâs ability to rapidly overcome host resistance through adaptation. The efficacy of a set of new resistance genes introgressed from Middle Eastern wild wheat relatives was measured using powdery mildew populations from various wheat growing regions affected by the disease (Kloppe et al., 2022). A more unusual wild relative of wheat, Psathyrostachys huashanica, which is found only in the Huashan Mountains of China, also furnished novel resistance to wheat powdery mildew (Liu et al., 2021).
A previously unidentified source of resistance to Hessian fly was identified in spring wheat cultivars of the U.S. Pacific Northwest (Prather et al., 2022). And in a twist, a locus conferring not resistance but susceptibility, in this case to tan spot, was identified in U.S. bi-parental spring wheat mapping populations and narrowed to a region encompassing seven candidate genes (Running et al., 2022). Last but not least, an interesting look under the ground revealed that rhizosphere microbiomes differed among wheat genotypes and had an impact on pathogenicity of Rhizoctonia solani, suggesting the potential to manage Rhizoctonia root rot with wheat genotypes that recruit microbiomes associated with improved plant fitness and suppression of the fungal pathogen (Dilla-Ermita et al., 2021).
For this Research Topic, we have collected articles that demonstrate how cutting-edge approaches to breeding are being brought to bear on some of the chief diseases threatening the worldâs wheat production systems. The authorsâ contributions are of the highest quality, and illustrate the strong international interest in this topic. These reports help breeders everywhere assess and employ novel and potentially durable resistance to wheat diseases. They will make a practical difference in helping safeguard global wheat yields in the challenging years to come
N and Xe Gas Scintillation Cross-Section, Spectrum, and Lifetime Measurements from 50 MeV to 26 GeV at the CERN PS and Booster
Beam parameters in CERN's Proton Synchrotron (PS) accelerator must be controlled (and measured) with tighter precision than ever before to meet the stringent requirements of the Large Hadron Collider (LHC) programme. A non-destructive beam profile measurement system would be a valuable diagnostic tool. To this end, we measured N2 and Xe gas scintillation absolute cross-sections and lifetimes for proton beam energies from 1.4 to 25 GeV, which should prove valuable in the design and construction of a gas scintillation profile measurement system. We also measured relative cross-sections for proton beam energies between 0.05 and 1.4 GeV
Modeling rhythmic patterns in the hippocampus
We investigate different dynamical regimes of neuronal network in the CA3
area of the hippocampus. The proposed neuronal circuit includes two fast- and
two slowly-spiking cells which are interconnected by means of dynamical
synapses. On the individual level, each neuron is modeled by FitzHugh-Nagumo
equations. Three basic rhythmic patterns are observed: gamma-rhythm in which
the fast neurons are uniformly spiking, theta-rhythm in which the individual
spikes are separated by quiet epochs, and theta/gamma rhythm with repeated
patches of spikes. We analyze the influence of asymmetry of synaptic strengths
on the synchronization in the network and demonstrate that strong asymmetry
reduces the variety of available dynamical states. The model network exhibits
multistability; this results in occurrence of hysteresis in dependence on the
conductances of individual connections. We show that switching between
different rhythmic patterns in the network depends on the degree of
synchronization between the slow cells.Comment: 10 pages, 9 figure
The boundary state for a class of analytic solutions in open string field theory
We construct a boundary state for a class of analytic solutions in the
Witten's open string field theory. The result is consistent with the property
of the zero limit of a propagator's length, which was claimed in [19]. And we
show that our boundary state becomes expected one for the perturbative vacuum
solution and the tachyon vacuum solution. We also comment on possible presence
of multi-brane solutions and ghost brane solutions from our boundary state.Comment: 19 pages, 2 figure
Electrophoretic Deposition of WS2 Flakes on Nanoholes ArraysâRole of Used Suspension Medium
Here we optimized the electrophoretic deposition process for the fabrication of WS2 plasmonic nanohole integrated structures. We showed how the conditions used for site-selective deposition influenced the properties of the deposited flakes. In particular, we investigated the effect of different suspension buffers used during the deposition both in the efficiency of the process and in the stability of WS2 flakes, which were deposited on an ordered arrays of plasmonic nanostructures. We observed that a proper buffer can significantly facilitate the deposition process, keeping the material stable with respect to oxidation and contamination. Moreover, the integrated plasmonic structures that can be prepared with this process can be applied to enhanced spectroscopies and for the preparation of 2D nanopores
Immunomodulatory effect of ibrutinib: Reducing the barrier against fungal infections
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib is increasingly used in the treatment of chronic lymphocytic leukemia (CLL). Moreover, very promising results have been reported in other B-cell malignancies, including primary central nervous system lymphoma (PCNSL). Although well-tolerated in the majority of patients, ibrutinib demonstrates in some cases troublesome toxicities, including invasive fungal infections (IFIs). In the present review, we summarize clinical manifestations of IFIs in patients treated with ibrutinib, generally characterized by an early onset, mild clinical manifestations, asymptomatic/low symptomatic pulmonary localization and high incidence of central nervous system (CNS) involvement. IFI risk appears particularly increased in patients receiving ibrutinib associated with other immune modulator agents, especially with steroids or immune-chemotherapy. Moreover, the immunomodulatory effect of ibrutinib is described, pointing the attention on the involvement of specific molecules targeted by ibrutinib in innate and adaptive response to fungal infection. Overall, the findings indicate the ibrutinib may rapidly impair innate immune cell functions, while concomitantly restoring an effective protective potential of adaptive immune compartment. A correct awareness, especially when other predisposing factors are present, is warranted about the potential risk of IFIs in ibrutinib-treated patients
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