A serological survey of ruminant livestock in Kazakhstan during post-Soviet transitions in farming and disease control

The results of a serological survey of livestock in Kazakhstan, carried out in 1997–1998, are reported. Serum samples from 958 animals (cattle, sheep and goats) were tested for antibodies to foot and mouth disease (FMD), bluetongue (BT), epizootic haemorrhagic disease (EHD), rinderpest (RP) and peste des petits ruminants (PPR) viruses, and to Brucella spp. We also investigated the vaccination status of livestock and related this to changes in veterinary provision since independence in 1991. For the 2 diseases under official surveillance (FMD and brucellosis) our results were similar to official data, although we found significantly higher brucellosis levels in 2 districts and widespread ignorance about FMD vaccination status. The seroprevalence for BT virus was 23%, and seropositive animals were widespread suggesting endemicity, despite the disease not having being previously reported. We found a few seropositives for EHDV and PPRV, which may suggest that these diseases are also present in Kazakhstan. An hierarchical model showed that seroprevalence to FMD and BT viruses were clustered at the farm/village level, rather than at a larger spatial scale. This was unexpected for FMD, which is subject to vaccination policies which vary at the raion (county) level

The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance

Many insects, including Drosophila, succumb to the physiological effects of chilling at temperatures well above those causing freezing. Low temperature causes a loss of extracellular ion and water homeostasis in such insects, and chill injuries accumulate. Using an integrative and comparative approach, we examined the role of ion and water balance in insect chilling susceptibility/ tolerance. The Malpighian tubules (MT), of chill susceptible Drosophila species lost [Na+] and [K+] selectivity at low temperatures, which contributed to a loss of Na+ and water balance and a deleterious increase in extracellular [K+]. By contrast, the tubules of chill tolerant Drosophila species maintained their MT ion selectivity, maintained stable extracellular ion concentrations, and thereby avoided injury. The most tolerant species were able to modulate ion balance while in a cold-induced coma and this ongoing physiological acclimation process allowed some individuals of the tolerant species to recover from chill coma during low temperature exposure. Accordingly, differences in the ability to maintain homeostatic control of water and ion balance at low temperature may explain large parts of the wide intra- and interspecific variation in insect chilling tolerance

Comparative study of design: application to Engineering Design

A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops. A systematic framework is used to collect data from expert witnesses who are practising designers across domains from engineering through architecture to product design and fashion, including film production, pharmaceutical drugs, food, packaging, graphics and multimedia and software. Similarities and differences across domains are described which indicate the types of comparative analysis we have been able to do from our data. The paper goes further and speculates on possible lessons for selected areas of engineering design which can be drawn from comparison with processes in other domains. As such this comparative design study offers the potential for improving engineering design processes. More generally it is a first step in creating a discipline of comparative design which aims to provide a new rich picture of design processes

Is copyright blind to the visual?

This article argues that, with respect to the copyright protection of works of visual art, the general uneasiness that has always pervaded the relationship between copyright law and concepts of creativity produces three anomalous results. One of these is that copyright lacks much in the way of a central concept of 'visual art' and, to the extent that it embraces any concept of the 'visual', it is rooted in the rhetorical discourse of the Renaissance. This means that copyright is poorly equipped to deal with modern developments in the visual arts. Secondly, the pervasive effect of rhetorical discourse appears to have made it particularly difficult for copyright law to strike a meaningful balance between protecting creativity and permitting its use in further creative works. Thirdly, just when rhetorical discourse might have been useful in identifying the significance and materiality of the unique one-off work of visual art, copyright law chooses to ignore its implications

Kinetics of Colour Change of Tomatoes During Drying

Colour is one of the pharameters determining the quality of dried tomatoes. The changes in colour of the skin of tomatoes during drying in an experimental dryer at various temperatures were measured every two hours by using Minolta CR 200 colorimeter and the colours were represented in Hunter-Lab scale. The objective of this research was develop a model for predicting colour changes of tomatoes during drying. The decrease in darkness as represented by dL value varied from 10 to 16%, while decrease in chroma value (dL) varied from 20 to 37% of initial values. An empirical logarithmic equation with six constants was derived to fit the data of chroma changes during drying at various temperature and times. The model of colour change of tomatoes can be used for determining the optimum drying temperature to produce acceptable colour of dried tomatoes at reasonable cost

AMPK-α1 or AMPK-α2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia

The hypoxic ventilatory response (HVR) is markedly attenuated by AMPK-α1 deletion conditional on the expression of Cre-recombinase in tyrosine hydroxylase (TH) expressing cells, precipitating marked increases in apnea frequency and duration. It was concluded that ventilatory dysfunction caused by AMPK deficiency was driven by neurogenic mechanisms. However, TH is transiently expressed in other cell types during development, and it is evident that central respiratory depression can also be triggered by myogenic mechanisms that impact blood supply to the brain. We therefore assessed the effect on the HVR and systemic arterial blood pressure of AMPK deletion in vascular smooth muscles. There was no difference in minute ventilation during normoxia. However, increases in minute ventilation during severe hypoxia (8% O2) were, if affected at all, augmented by AMPK-α1 and AMPK-α2 deletion in smooth muscles; despite the fact that hypoxia (8% O2) evoked falls in arterial SpO2 comparable with controls. Surprisingly, these mice exhibited no difference in systolic, diastolic or mean arterial blood pressure during normoxia or hypoxia. We conclude that neither AMPK-α1 nor AMPK-α2 are required in smooth muscle for the regulation of systemic arterial blood pressure during hypoxia, and that AMPK-α1 deficiency does not impact the HVR by myogenic mechanisms

The BGS magnetic field candidate models for the 12th generation IGRF

We describe the candidate models submitted by the British Geological Survey for the 12th generation International Geomagnetic Reference Field. These models are extracted from a spherical harmonic ‘parent model’ derived from vector and scalar magnetic field data from satellite and observatory sources. These data cover the period 2009.0 to 2014.7 and include measurements from the recently launched European Space Agency (ESA) Swarm satellite constellation. The parent model’s internal field time dependence for degrees 1 to 13 is represented by order 6 B-splines with knots at yearly intervals. The parent model’s degree 1 external field time dependence is described by periodic functions for the annual and semi-annual signals and by dependence on the 20-min Vector Magnetic Disturbance index. Signals induced by these external fields are also parameterized. Satellite data are weighted by spatial density and by two different noise estimators: (a) by standard deviation along segments of the satellite track and (b) a larger-scale noise estimator defined in terms of a measure of vector activity at the geographically closest magnetic observatories to the sample point. Forecasting of the magnetic field secular variation beyond the span of data is by advection of the main field using core surface flows

Higher education, career opportunities, and intergenerational inequality

The UK government has expressed a desire to increase social mobility, with policies to help achieve this aim focused on reducing inequalities in educational attainment. This paper draws together established and new information about the contribution that higher education can make to social mobility using a life-course approach, considering differences by family background in terms of university attendance and achievement, as well as occupation and earnings following graduation. We find substantial socio-economic differences at each stage. Young people from poorer backgrounds are, on average, less likely to go to university than their richer peers. Even among the selected group who do go to university, they are less likely to attend the highest status institutions, less likely to graduate, and less likely to achieve the highest degree classes. These differences in degree outcomes contribute to the lower average earnings of graduates from poorer families, but earnings differentials go well beyond those driven purely by degree attainment or institution attended. The evidence strongly suggests that, even after taking these factors into account, graduates from affluent families are more likely to obtain a professional job and to see higher earnings growth in the labour market. We discuss the implications of these findings for the prospects of higher education as a route to greater social mobility

Recent BGS activities for the Swarm DISC

The British Geological Survey is responsible for the fast-track magnetospheric field model product (MMA_SHA_2F), geomagnetic observatory data (AUX_OBS*2_) products and Level 2 CAT-1 product validation, as part of the consortium of institutes making up the Swarm Expert Support Laboratory. We summarise these activities and provide updates since the Living Planet Symposium in June 2016. The fast-track magnetospheric field model product is generated automatically and disseminated on a daily basis after receipt of the Swarm L1b files. With more than three years of accumulated models, we comment on the longer-term behaviour of the magnetospheric field. The observatory hourly-mean (AUX_OBS_2_) data product is updated every 3 months using a selection of definitive and quasi-definitive data from observatories around the world. Since Swarm was launched, good quality data from about 120 observatories are available. BGS started issuing new observatory data products in October 2016 with a 4-day lag. Regular updates are made if new data are found. These products consist of 1-second observatory (AUX_OBSS2_) and 1-minute (AUX_OBSM2_) quasi-definitive data from the start of the Swarm mission, and are made available on the BGS anonymous FTP server at ftp://ftp.nerc-murchison.ac.uk/geomag/Swarm/AUX_OBS/. A summary of temporal and spatial coverage of all observatory data products is provided. Validation of the Level 2 CAT-1 products comprises comparisons of the Swarm-based models to independent models and data where possible, and inter-comparisons of models from the dedicated and comprehensive processing chains. A selection of plots from recent validation reports is given