General Relativity and Gravitation: A Centennial Perspective

To commemorate the 100th anniversary of general relativity, the International Society on General Relativity and Gravitation (ISGRG) commissioned a Centennial Volume, edited by the authors of this article. We jointly wrote introductions to the four Parts of the Volume which are collected here. Our goal is to provide a bird's eye view of the advances that have been made especially during the last 35 years, i.e., since the publication of volumes commemorating Einstein's 100th birthday. The article also serves as a brief preview of the 12 invited chapters that contain in-depth reviews of these advances. The volume will be published by Cambridge University Press and released in June 2015 at a Centennial conference sponsored by ISGRG and the Topical Group of Gravitation of the American Physical Society.Comment: 37 page

Godel-type space-time metrics

A simple group theoretic derivation is given of the family of space-time metrics with isometry group SO(2,1) X SO(2) X R first described by Godel, of which the Godel stationary cosmological solution is the member with a perfect-fluid stress-energy tensor. Other members of the family are shown to be interpretable as cosmological solutions with a electrically charged perfect fluid and a magnetic field.Comment: Heavly rewritten respect to the orginal version, corrected some typos due to files transfer in the last submitted versio

Dvali-Gabadadze-Porrati Cosmology in Bianchi I brane

The dynamics of Dvali-Gabadadze-Porrati Cosmology (DGP) braneworld with an anisotropic brane is studied. The Friedmann equations and their solutions are obtained for two branches of anisotropic DGP model. The late time behavior in DGP cosmology is examined in the presence of anisotropy which shows that universe enters a self-accelerating phase much later compared to the isotropic case. The acceleration conditions and slow-roll conditions for inflation are obtained

An exterior for the G\"{o}del spacetime

We match the vacuum, stationary, cylindrically symmetric solution of Einstein's field equations with $\Lambda$, in a form recently given by Santos, as an exterior to an infinite cylinder of dust cut out of a G\"{o}del universe. There are three cases, depending on the radius of the cylinder. Closed timelike curves are present in the exteriors of some of the solutions. There is a considerable similarity between the spacetimes investigated here and those of van Stockum referring to an infinite cylinder of rotating dust matched to vacuum, with $\Lambda=0$.Comment: 11 pages, LaTeX 2.09, no figures. Submitted to Classical and Quantum Gravit

Patient safety and estimation of renal function in patients prescribed new oral anticoagulants for stroke prevention in atrial fibrillation

OBJECTIVE: In clinical trials of dabigatran and rivaroxaban for stroke prevention in atrial fibrillation (AF), drug eligibility and dosing were determined using the Cockcroft-Gault equation to estimate creatine clearance as a measure of renal function. This cross-sectional study aimed to compare whether using estimated glomerular filtration rate (eGFR) by the widely available and widely used Modified Diet in Renal Disease (MDRD) equation would alter prescribing or dosing of the renally excreted new oral anticoagulants. PARTICIPANTS: Of 4712 patients with known AF within a general practitioner-registered population of 930 079 in east London, data were available enabling renal function to be calculated by both Cockcroft-Gault and MDRD methods in 4120 (87.4%). RESULTS: Of 4120 patients, 2706 were <80 years and 1414 were ≥80 years of age. Among those ≥80 years, 14.9% were ineligible for dabigatran according to Cockcroft-Gault equation but would have been judged eligible applying MDRD method. For those <80 years, 0.8% would have been incorrectly judged eligible for dabigatran and 5.3% would have received too high a dose. For rivaroxaban, 0.3% would have been incorrectly judged eligible for treatment and 13.5% would have received too high a dose. CONCLUSIONS: Were the MDRD-derived eGFR to be used instead of Cockcroft-Gault in prescribing these new agents, many elderly patients with AF would either incorrectly become eligible for them or would receive too high a dose. Safety has not been established using the MDRD equation, a concern since the risk of major bleeding would be increased in patients with unsuspected renal impairment. Given the potentially widespread use of these agents, particularly in primary care, regulatory authorities and drug companies should alert UK doctors of the need to use the Cockcroft-Gault formula to calculate eligibility for and dosing of the new oral anticoagulants in elderly patients with AF and not rely on the MDRD-derived eGFR

Ionomer-Membrane Water Processing Apparatus

This disclosure provides water processing apparatuses, systems, and methods for recovering water from wastewater such as urine. The water processing apparatuses, systems, and methods can utilize membrane technology for extracting purified water in a single step. A containment unit can include an ionomer membrane, such as Nafion.RTM., over a hydrophobic microporous membrane, such as polytetrafluoroethylene (PTFE). The containment unit can be filled with wastewater, and the hydrophobic microporous membrane can be impermeable to liquids and solids of the wastewater but permeable to gases and vapors of the wastewater, and the ionomer membrane can be permeable to water vapor but impermeable to one or more contaminants of the gases and vapors. The containment unit can be exposed to a dry purge gas to maintain a water vapor partial pressure differential to drive permeation of the water vapor, and the water vapor can be collected and processed into potable water

Self-dual Einstein Spaces, Heavenly Metrics and Twistors

Four-dimensional quaternion-Kahler metrics, or equivalently self-dual Einstein spaces M, are known to be encoded locally into one real function h subject to Przanowski's Heavenly equation. We elucidate the relation between this description and the usual twistor description for quaternion-Kahler spaces. In particular, we show that the same space M can be described by infinitely many different solutions h, associated to different complex (local) submanifolds on the twistor space, and therefore to different (local) integrable complex structures on M. We also study quaternion-Kahler deformations of M and, in the special case where M has a Killing vector field, show that the corresponding variations of h are related to eigenmodes of the conformal Laplacian on M. We exemplify our findings on the four-sphere S^4, the hyperbolic plane H^4 and on the "universal hypermultiplet", i.e. the hypermultiplet moduli space in type IIA string compactified on a rigid Calabi-Yau threefold.Comment: 44 pages, 1 figure; misprints correcte

An expression map for Anopheles gambiae

<p>Abstract</p> <p>Background</p> <p>Quantitative transcriptome data for the malaria-transmitting mosquito <it>Anopheles gambiae </it>covers a broad range of biological and experimental conditions, including development, blood feeding and infection. Web-based summaries of differential expression for individual genes with respect to these conditions are a useful tool for the biologist, but they lack the context that a visualisation of <it>all </it>genes with respect to <it>all </it>conditions would give. For most organisms, including <it>A. gambiae</it>, such a systems-level view of gene expression is not yet available.</p> <p>Results</p> <p>We have clustered microarray-based gene-averaged expression values, available from VectorBase, for 10194 genes over 93 experimental conditions using a self-organizing map. Map regions corresponding to known biological events, such as egg production, are revealed. Many individual gene clusters (nodes) on the map are highly enriched in biological and molecular functions, such as protein synthesis, protein degradation and DNA replication. Gene families, such as odorant binding proteins, can be classified into distinct functional groups based on their expression and evolutionary history. Immunity-related genes are non-randomly distributed in several distinct regions on the map, and are generally distant from genes with house-keeping roles. Each immunity-rich region appears to represent a distinct biological context for pathogen recognition and clearance (e.g. the humoral and gut epithelial responses). Several immunity gene families, such as peptidoglycan recognition proteins (PGRPs) and defensins, appear to be specialised for these distinct roles, while three genes with physically interacting protein products (LRIM1/APL1C/TEP1) are found in close proximity.</p> <p>Conclusions</p> <p>The map provides the first genome-scale, multi-experiment overview of gene expression in <it>A. gambiae </it>and should also be useful at the gene-level for investigating potential interactions. A web interface is available through the VectorBase website <url>http://www.vectorbase.org/</url>. It is regularly updated as new experimental data becomes available.</p

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

The survival of all microbes depends upon their ability to respond to environmental challenges. To establish infection, pathogens such as Candida albicans must mount effective stress responses to counter host defences while adapting to dynamic changes in nutrient status within host niches. Studies of C. albicans stress adaptation have generally been performed on glucose-grown cells, leaving the effects of alternative carbon sources upon stress resistance largely unexplored. We have shown that growth on alternative carbon sources, such as lactate, strongly influence the resistance of C. albicans to antifungal drugs, osmotic and cell wall stresses. Similar trends were observed in clinical isolates and other pathogenic Candida species. The increased stress resistance of C. albicans was not dependent on key stress (Hog1) and cell integrity (Mkc1) signalling pathways. Instead, increased stress resistance was promoted by major changes in the architecture and biophysical properties of the cell wall. Glucose- and lactate-grown cells displayed significant differences in cell wall mass, ultrastructure, elasticity and adhesion. Changes in carbon source also altered the virulence of C. albicans in models of systemic candidiasis and vaginitis, confirming the importance of alternative carbon sources within host niches during C. albicans infection