20 research outputs found
Making Sense of the Law and Society Movement
This article aims to deepen scholarly understanding of the
Law and Society Movement (L&S) and thereby strengthen
debates about the relation between Empirical Legal Studies
(ELS) and L&S. The article departs from the observation that
ELS, understood as an initiative that emerged in American
law schools in the early 2000s, has been quite successful in
generating more attention to the empirical study of law and
legal institutions in law schools, both in- and outside the US.
In the early years of its existence, L&S – another important
site for the empirical study of law and legal institutions –
also had its center of gravity inside the law schools. But over
time, it shifted towards the social sciences. This article discusses
how that happened, and more in general explains
how L&S became ever more diverse in terms of substance,
theory and methods
Ethnic profiling in the Netherlands? A reflection on expanding preventive powers, ethnic profiling and a changing social and political context
Criminal Justice: Legitimacy, accountability, and effectivit
Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma:TRAP Study
PURPOSE: Approximately 15% to 43% of esophageal adenocarcinomas (EACs) are human epidermal growth factor receptor 2 (HER2) positive. Because dual-agent HER2 blockade demonstrated a survival benefit in breast cancer, we conducted a phase II feasibility study of trastuzumab and pertuzumab added to neoadjuvant chemoradiotherapy (nCRT) in patients with EAC. PATIENTS AND METHODS: Patients with resectable HER2-positive EAC received standard nCRT with carboplatin and paclitaxel and 41.4 Gy of radiotherapy, with 4 mg/kg of trastuzumab on day 1, 2 mg/kg per week during weeks 2 to 6, and 6 mg/kg per week during weeks 7, 10, and 13 and 840 mg of pertuzumab every 3 weeks. The primary end point was feasibility, defined as ≥ 80% completion of treatment with both trastuzumab and pertuzumab. An exploratory comparison of survival with a propensity score-matched cohort receiving standard nCRT was performed, as were exploratory pharmacokinetic and biomarker analyses. RESULTS: Of the 40 enrolled patients (78% men; median age, 63 years), 33 (83%) completed treatment with trastuzumab and pertuzumab. No unexpected safety events were observed. R0 resection was achieved in all patients undergoing surgery, with pathologic complete response in 13 patients (34%). Three-year progression-free and overall survival (OS) were 57% and 71%, respectively (median follow-up, 32.1 months). Compared with the propensity score-matched cohort, a significantly longer OS was observed with HER2 blockade (hazard ratio, 0.58; 95% CI, 0.34 to 0.97). Results of pharmacokinetic analysis and activity on [18F]fluorodeoxyglucose positron emission tomography scans did not correlate with survival or pathologic response. Patients with HER2 3+ overexpression or growth factor receptor-bound protein 7 (Grb7) -positive tumors at baseline demonstrated significantly better survival (P = .007) or treatment response (P = .016), respectively. CONCLUSION: Addition of trastuzumab and pertuzumab to nCRT in patients with HER2-positive EAC is feasible and demonstrates potentially promising activity compared with historical controls. HER2 3+ overexpression and Grb7 positivity are potentially predictive for survival and treatment response, respectively
LISS panel > The public’s opinion on the control of terrorism: Attitudes and willingness-to-pay > Wave 1
This is the first wave of the study "The public’s opinion on the control of terrorism: Attitudes and willingness-to-pay"
The Negotiated Expansions of Immigration Control
This work emerged out of the Law and Society Association\u27s (LSA) Citizenship and Immigration Collaborative Research Network (CRN). The symposium editors would like to thank members of the CRN for their contributions to this intellectual community as well as the LSA for making it possible. A debt of gratitude is also owed to Marjorie Zatz and Doris Marie Provine for offering helpful comments on a previous draft of this introduction and for providing invaluable assistance throughout the process of compiling this symposium
Governing Migration through COVID-19? Dutch Political and Media Discourse in Times of a Pandemic
This article explores the political and media discourse in The Netherlands around COVID-19 and migration. In so doing, it asks to what extent the dynamics of ‘governing COVID-19 through migration’ are visible in this discourse. By asking this question, the article builds upon the theoretical frameworks of ‘governing through crime’ and ‘governing through migration control’. Both theoretical frameworks place a strong emphasis on the role of discourse in framing certain social phenomena as a threat, concern or risk. By carrying out a discourse analysis on Dutch political and media debates around COVID-19 and migration in the period 1 January 2020–1 November 2021, the article illustrates that despite the linking of migration and crime not only being very visible but also seemingly normalized in this discourse, the links made between COVID-19 and migration were much more nuanced. Furthermore, although COVID-19 and migration were discussed together, the discourse does not show any evidence of governing COVID-19 through migration by using the pandemic to push for very restrictive migration laws targeting only ‘vagabonds’ while still allowing the mobility of ‘tourists’)
Guest Editorial: Transforming Borders and the Discretionary Politics of Migration Control
The eight articles in this issue promise us a global journey around transformed borders, multiscalar bordering, and discretionary practices within these migration controls. In doing so, the authors guide us through the Global North and Global South with countries as varied as the US, Mexico, Mali, Poland, Norway, the Netherlands, the United Kingdom (UK), Spain, Italy, Germany, Greece, and Turkey. We also gain insights through these specific research settings from additional Asian and African countries of origin for the migrants involved. By situating their analyses in a specific locus, the authors provide us with a grounded, localized narrative, which they insightfully theorize on and interact with at the global level. Through these glocalized analyses, we not only learn about the importance of multiscalar forms of migration control and the discretion of these actors within these bordering practices, but also gain insights into the immediate and long-term effects of these control efforts on the divergent actors that transform our borders and give meaning to the multiscalar bordering practices.
Crimmigration at the Internal Borders of Europe?<br>Examining the Schengen Governance Package
This article focuses on how the Schengen Governance Package, and in particular the revised legal framework on the temporary reinstatement of internal border checks, should be valued within the broader process of crimmigration. First we elaborate upon both the recent incidents that underline the criminalization of migration in Europe and the recent developments in the Schengen legal framework on internal border control. Subsequently, based on an analysis of official notification letters issued by the respective Member States, we analyse the development of how often, and on which grounds, they temporarily closed their internal borders in the period of January 2000 - March 2014. In doing so, we pay attention not only to the question whether Member States have been using (the fear of) (cr)immigration as a reason to invoke the exception clause, but also to the transparency of the procedures that were followed. Following an assessment of the Schengen Governance Package in light of this analysis, we address certain other forms of border control developing within the Schengen zone. In conclusion, we argue that the way in which the European Commission and the Council responded to immigration-related anxieties is understandable but might have contrary effects in the long run
(Cr)immigrant framing in border areas: decision-making processes of Dutch border police officers
Criminal Justice: Legitimacy, accountability, and effectivit