Surgical resection of localized hepatocellular carcinoma: patient selection and special consideration

published_or_final_versio

Standardizing laparoscopic left lateral sectionectomy for hepatocellular carcinoma

published_or_final_versio

An update on the management of intrahepatic cholangiocarcinoma

Reviewpublished_or_final_versio

Collaborative Mass Housing Design practice with Smart Models

中国数字建筑设计专业委员会'数字渗透'系列活动 2013DADA数字建筑国际学术研讨会Conference Theme: Digital Infiltration: Computation, Generation, Optimisation, Fabrication, Construction and ManagementMass housing, due to its repetitive patterns, provides great opportunities for the rule-based parametric design. Design rules and logics can be formulated to generate various design solutions, also known as rule-based design process. In addition, mass housing design ought to be a complex process that involves not only the architects, developers and contractors, but also ideally, includes the users. In reality, however, the users are always excluded during the design process as there is no such a system that provides simple, effective and feasible design communication mechanisms. This meta-paper aims to collates and presents all possible parameters that are affiliated with mass housing. It will explore into various levels of scales from urban to building-units to map out the interconnected relationships. The outcomes open up new possibilities to apply parametric modeling in mass housing design practice.postprin

FXN promoter silencing in the humanized mouse model of Friedreich Ataxia

Background - Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter. This silencing mechanism is seen in patient-derived lymphoblastoid cells but it remains unknown if it is a widespread phenomenon affecting multiple cell types and tissues. Methodology / Principal Findings - The humanized mouse model of Friedreich ataxia (YG8sR), which carries a single transgenic insert of the human FXN gene with an expanded GAA triplet-repeat in intron 1, is deficient for FXN transcript when compared to an isogenic transgenic mouse lacking the expanded repeat (Y47R). We found that in YG8sR the deficiency of FXN transcript extended both upstream and downstream of the expanded GAA triplet-repeat, suggestive of deficient transcriptional initiation. This pattern of deficiency was seen in all tissues tested, irrespective of whether they are known to be affected or spared in disease pathogenesis, in both neuronal and non-neuronal tissues, and in cultured primary fibroblasts. FXN promoter function was directly measured via metabolic labeling of newly synthesized transcripts in fibroblasts, which revealed that the YG8sR mouse was significantly deficient in transcriptional initiation compared to the Y47R mouse. Conclusions / Significance- Deficient transcriptional initiation accounts for FXN transcriptional deficiency in the humanized mouse model of Friedreich ataxia, similar to patient-derived cells, and the mechanism underlying promoter silencing in Friedreich ataxia is widespread across multiple cell types and tissues.This research was supported by grants from the National Institutes of Health (R01 NS072418), and the Muscular Dystrophy Association to S.I.B. Y.K.C. is supported by a postdoctoral research fellowship from the Million Dollar Bike Ride Grant Program of the Orphan Disease Center at University of Pennsylvania. T.T.H. was supported by the American College of Medical Genetics Foundation. A.C.P. and M.G.M. were supported by the SURE and OSCTR programs at OUHSC, respectively

A compact HF/UHF dual band RFID tag antenna

This paper presents a novel dual band RFID (radio frequency identification) tag antenna. Two challenges are faced: the compact dimension and the impaired bandwidth due to the couplings between two band structures. A spiral coil is designed to handle the HF (13.56MHz) near field coupling, and a diagonal symmetric design consisting of two meander lines are placed inside the coil for UHF band (915MHz). This structure supports multiple resonance modes around 915MHz to broaden the working bandwidth under the large inductive circumstance from the HF coil. The proposed antenna is easy to adjust by both coarse tuning and fine tuning. Its overall dimension is of a credit card size on a single layer thin substrate. © 2013 IEEE.published_or_final_versio

MuDelta: Delta-Oriented Mutation Testing at Commit Time

To effectively test program changes using mutation testing, one needs to use mutants that are relevant to the altered program behaviours. In view of this, we introduce MuDelta, an approach that identifies commit-relevant mutants; mutants that affect and are affected by the changed program behaviours. Our approach uses machine learning applied on a combined scheme of graph and vector-based representations of static code features. Our results, from 50 commits in 21 Coreutils programs, demonstrate a strong prediction ability of our approach; yielding 0.80 (ROC) and 0.50 (PR Curve) AUC values with 0.63 and 0.32 precision and recall values. These predictions are significantly higher than random guesses, 0.20 (PR-Curve) AUC, 0.21 and 0.21 precision and recall, and subsequently lead to strong relevant tests that kill 45%more relevant mutants than randomly sampled mutants (either sampled from those residing on the changed component(s) or from the changed lines). Our results also show that MuDelta selects mutants with 27% higher fault revealing ability in fault introducing commits. Taken together, our results corroborate the conclusion that commit-based mutation testing is suitable and promising for evolving software

Phytochemical and anti‐plasmodial screening of three selected tropical plants used for the treatment of malaria in Oshogbo, south-western Nigeria

The use of herbal remedy is featuring prominently as alternative to orthodox medicine but little is known on scientific validation of their efficacies in malaria treatment. Questionnaire survey was conducted in Osogbo metropolis to identify the frequently used antiplasmodial herbal remedies. The aqueous extracts of the three frequently used antimalaria herbs, Mangifera indica leaves, Lawsonia inermis leaves and Enanthia chlorantha stem bark were prepared as described by herbal vendors and subsequently analyzed for phytochemical constituents and antiplasmodial efficiencies using mice model. The qualititave phytochemical analysis of the extracts showed differences in the phytochemical constituents of the three plants. The comparison of the parasite load before and after treatment showed that the parasitamia level reduced significantly (p < 0.05) in the mice treated with E. chlorantha and M. indica but increased significantly (p = 0.012; p < 0.05) in the group treated with L. inermis while no parasite was detected in the group treated with chloroquine (antimalaria drug) after treatment. The treated groups had higher concentrations of creatinine, urea, bilirubin, Aspartate aminotransferase and Alkaline phosphate in comparison with the control, an indication of the plant extracts cyto‐toxicity. The results therefore showed that the extracts of E. chlorantha and M. indica only possess chemosupressive not curative antimalaria potential while L. inermis did not show any antiplasmodial effect. Further screening on antimalaria herbal remedies therefore becomes imperative so as to guide the policy on malaria treatment regime in Nigeria.Key words: Phytochemistry, antiplasmodial, plant extracts, biochemical marker

An Assessment Of Traditional Uighur Medicine In Current Xinjiang Region (China)

Background: The main objectives of this study were to assess the current research and development of traditional Uighur medicine in Xinjiang (China), and to evaluate the promising pharmacological products of traditional Uighur medicine for further studies.Materials and Methods: Traditional Uighur medicine data of medicine registry, patent, and academic publications was collected and analyzed.Results: Data showed that, among the registered and studied traditional Uighur medicine, the main therapeutic areas of traditional Uighur medicine focused on skin disease, urogenital disease, rheumatism and digestive system disease. The representative traditional Uighur patent medicine included the following: BaixuanXiatare Tablets, Kaliziran Tincture and Vernoniaanthelmintica Injection (Psoriasis and vitiligo); Xi-payimazibiziLiquid (prostatitis); KursiKaknaq (urinary tract infection); Tongzhisurunjiang Capsules (anti-rheumatism medicine); HuganBuzure Granules (digestive system disease). Moreover, ten Uighur herbs were widely used, including: ResinaScammoniae, Folium FumicisDentati, HerbaDracocephali, Semen AmygdaliDulcis, HerbaChamomillae, FructusPimpinellaeanisi, Cortex Foeniculi, FructusVernoniae, FructusApii, and Radix AnacycliPyrethri.Conclusion: This study concluded by indicating that traditional Uighur medicine with excellent curative effect should be screened in details for their phytochemical properties and pharmacological activity to discover new bioactive constituents.Key words: Traditional Uighur medicine, Traditional Uighur patent medicine, Uighur her