Organic matter responses to radiation under lunar conditions

Large bodies, such as the Moon, which have remained relatively unaltered for long periods of time have the potential to preserve a record of organic chemical processes from early in the history of the solar system. A record of volatiles and impactors may be preserved in buried lunar regolith layers that have been capped by protective lava flows. Of particular interest is the possible preservation of prebiotic organic materials delivered by ejected fragments of other bodies, including those originating from the surface of the early Earth. Lava flow layers would shield the underlying regolith and any carbon-bearing materials within them from most of the effects of space weathering, but the encapsulated organic materials would still be subject to irradiation before they were buried by regolith formation and capped with lava. We have performed a study to simulate the effects of solar radiation on a variety of organic materials mixed with lunar and meteorite analogue substrates. A fluence of ~3 x 1013 protons cm-2 at 4-13 MeV, intended to be representative of solar energetic particles, has little detectable effect on low molecular weight (≤C30) hydrocarbon structures that can be used to indicate biological activity (biomarkers) or the high molecular weight hydrocarbon polymer poly(styrene-co-divinylbenzene), and has little apparent effect on a selection of amino acids (≤C9). Inevitably, more lengthy durations of exposure to solar energetic particles may have more deleterious effects and rapid burial and encapsulation will always be more favourable to organic preservation. Our data indicate that biomarker compounds that may be used to infer biological activity on their parent planet can be relatively resistant to the effects of radiation, and may have a high preservation potential in paleoregolith layers on the Moon

A Review Of The Evaluation Methods Of The Value Of Human Capital Of The Manager In China

Recent directives of the Chinese government specify property rights and income distribution for factors of production. The study as to how these factors are allotted appropriate shares of business income is becoming essential to the establishment of the China’s modern enterprise system. When the manager is regarded as one of the factors of production, how one measures the value-added becomes a component of the income distribution system of the business. This paper surveys traditional views of the manager as a human capital, and offers an alternative suggestion for the measurement of the human capital of the manager which can more accurately reflect the reality of the operation of the business

A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects

Background Previous diffusion tensor imaging (DTI) studies have consistently shown that subjects with cocaine use disorder (CocUD) had altered white matter microstructure in the corpus callosum. It is believed that these alterations are due to preexisting factors, chronic cocaine use, or both. However, there is no published longitudinal DTI study on human cocaine users yet which could shed light on the relationship between cocaine use and DTI findings. Methods This study used a longitudinal design and DTI to test if the white matter microstructure shows quicker alteration in CocUD subjects than controls. DTI data were acquired from eleven CocUD subjects who participated a treatment study and eleven non-drug-using controls at baseline (Scan 1) and after ten weeks (Scan 2). The baseline fractional anisotropy (FA), a general measure of white matter microstucture, and the change in FA (ΔFA, equals Scan 1 FA minus Scan 2 FA) were both compared between groups. Results The two groups did not show a difference in FA at baseline. The CocUD subjects had significantly greater ΔFA than the controls in the left splenium of the corpus callosum. In CocUD subjects, greater ΔFA in this region was associated with shorter lifetime cocaine use and greater number of positive cocaine urine samples collected during the treatment. Conclusion The finding in the left splenium is consistent with previous animal studies and provide indirect evidence about the effects of chronic cocaine use on white matter alterations. The subject sample size is small, therefore the results should be treated as preliminary

Virtual Clay Modeling using Adaptive Distance Fields

This paper describes an approach for the parametrization and modeling of objects represented by adaptive distance fields (ADFs). ADFs support the construction of powerful solid modeling tools. They can represent surfaces of arbitrary and even changing topology, while providing a more intuitive user interface than control-point based structures such as B-splines. Using the octree structure, an adaptively refined quadrilateral mesh is constructed that is topologically equivalent to the surface. The mesh is then projected onto the surface using multiple projection and smoothing steps. The resulting mesh serves as the ``interface'' for interactive modeling operations and high-quality rendering

Cocreation in Health Workforce Planning to Shape the Future of the Health Care System in the Philippines.

Background: The Philippines passed landmark legislation in 2019 on universal health coverage, including reforms in the development of its health workforce, an essential building block of responsive health care systems. Health Workforce Planning Cocreation Process: We based our planning process on a model of cocreation defined as sharing power and decision making to solve problems collaboratively and build consensus around action. Through cocreation with policy makers, researchers, and other stakeholders, we performed projection studies on 10 selected health professions and estimated the need for primary care at national and subnational levels, which was the most extensive health workforce projection carried out by the Philippine Department of Health to date. We determined health workforce requirements based on target densities recommended by the World Health Organization and a health needs approach that considered epidemiological and sociodemographic factors. In consultation with stakeholders, we interpreted our analysis to guide recommendations to address issues related to health workforce quantity, skill mix, and distribution. These included a broad range of proposals, including task shifting, expanding scholarships and deployment, reforming health professionals’ education, and pursuing a whole-of-society approach, which together informed the National Human Resources for Health Master Plan. Conclusions: Our cocreation model offers lessons for policy makers, program managers, and researchers in low- and middle-income countries who deal with health workforce challenges. Cocreation led to relationship building between policy makers and researchers who jointly performed the research and identified solutions through open communication and agile coordination. To shape future health care systems that are responsive both during normal times and during crises, cocreation would be essential for evidence-informed policy development and policy-relevant research

Cocreation in Health Workforce Planning to Shape the Future of the Health Care System in the Philippines

Background The Philippines passed landmark legislation in 2019 on universal health coverage, including reforms in the development of its health workforce, an essential building block of responsive health care systems. Health Workforce Planning Cocreation Process We based our planning process on a model of cocreation defined as sharing power and decision making to solve problems collaboratively and build consensus around action. Through cocreation with policy makers, researchers, and other stakeholders, we performed projection studies on 10 selected health professions and estimated the need for primary care at national and subnational levels, which was the most extensive health workforce projection carried out by the Philippine Department of Health to date. We determined health workforce requirements based on target densities recommended by the World Health Organization and a health needs approach that considered epidemiological and sociodemographic factors. In consultation with stakeholders, we interpreted our analysis to guide recommendations to address issues related to health workforce quantity, skill mix, and distribution. These included a broad range of proposals, including task shifting, expanding scholarships and deployment, reforming health professionals’ education, and pursuing a whole-of-society approach, which together informed the National Human Resources for Health Master Plan. Conclusions Our cocreation model offers lessons for policy makers, program managers, and researchers in low- and middle-income countries who deal with health workforce challenges. Cocreation led to relationship building between policy makers and researchers who jointly performed the research and identified solutions through open communication and agile coordination. To shape future health care systems that are responsive both during normal times and during crises, cocreation would be essential for evidence-informed policy development and policy-relevant research

W-DARE: a three-year program of participatory action research to improve the sexual and reproductive health of women with disabilities in the Philippines

BACKGROUND: In many contexts, women with disability have less access to sexual and reproductive health information, screening, prevention, and care services than women without disability. Women with disability are also known to be more likely to experience physical and sexual violence than women without disability. In the Philippines, health service providers often have little awareness of the sexual and reproductive experiences of women with disability and limited capacity to provide services in response to their needs. Very limited data are available to inform development of disability-inclusive sexual and reproductive health, and violence prevention and response, services in the country. This paper presents the protocol for W-DARE (Women with Disability taking Action on REproductive and sexual health), a three-year program of participatory action research that aims to improve the sexual and reproductive health of women with disability in the Philippines. DESIGN: W-DARE is a disability-inclusive program that will use mixed methods to 1) increase understanding of factors influencing the sexual and reproductive health of women with disability, and 2) develop, implement and evaluate local interventions to increase supply of and demand for services. W-DARE will generate data on the prevalence of disability in two districts; the wellbeing and community participation of people with and without disability, and identify barriers to community; and describe the sexual and reproductive health needs and experiences, and service-related experiences of women with disability. These data will inform the development and evaluation of interventions aiming to improve access to sexual and reproductive health services, and violence prevention and response services, for women with disability. Local women with disabilities, their representative organisations, and SRH service providers will be involved as members of the research team across all stages of the research. DISCUSSION: This three-year study will provide evidence about factors undermining the sexual and reproductive health of women with disability in a lower-middle income country, and provide new insights about what may be effective in increasing access to services in settings of limited resources. Findings will be relevant across Asia and the Pacific. Analysis of the program will also provide evidence about disability-inclusion in participatory action research approaches