2,834 research outputs found
Clinical measurements versus patient-reported outcomes: analysis of the American Shoulder and Elbow Surgeons physician assessment in patients undergoing reverse total shoulder arthroplasty.
BackgroundThe American Shoulder and Elbow Surgeons (ASES) score is composed of a patient-reported portion and a physician assessment. Although the patient-reported score is frequently used to assess postoperative outcomes after shoulder arthroplasty, no previous studies have used the physician-assessment component. This study evaluated the relationship of the ASES physician-assessment measurements with patient-reported shoulder and general health outcomes.MethodsA retrospective review of a prospectively collected multicenter database was used to analyze patients who underwent primary reverse total shoulder arthroplasty (RTSA) from 2012 to 2015 with a minimum 2-year follow-up. ASES physician-assessment and patient-reported components and 12-Item Short Form Health Survey (SF-12) general health questionnaires were obtained preoperatively and 2 years postoperatively. The relationship between ASES physician measurements with ASES patient-reported outcome (PRO) scores and SF-12 Physical and Mental domain scores was assessed with Pearson correlation coefficients.ResultsIncluded were 74 patients (32 men; mean age, 69.2 years; body mass index, 29.4 kg/m2). Preoperative physician measurements and PRO scores were not significantly correlated. Postoperatively, only the ASES physician-measured active (R = 0.54, P < .01) and passive forward flexion (R = 0.53, P < .01) demonstrated moderate correlation with ASES patient scores. The remaining clinical measurements had no significant correlations with ASES patient or SF-12 scores. During the 2-year period, only improvements in active forward flexion correlated with improvements in ASES patient scores (R = 0.36, P < .01).ConclusionsLittle correlation exists between clinical measurements from the ASES physician component and PROs, including the ASES patient-reported and SF-12 general health surveys, in RTSA patients. Improvement in active forward flexion is the only clinical measurement correlated with PRO improvement at 2 years
Vision-Aided Autonomous Landing and Ingress of Micro Aerial Vehicles
Micro aerial vehicles have limited sensor suites and computational power. For reconnaissance tasks and to conserve energy, these systems need the ability to autonomously land at vantage points or enter buildings (ingress). But for autonomous navigation, information is needed to identify and guide the vehicle to the target. Vision algorithms can provide egomotion estimation and target detection using input from cameras that are easy to include in miniature systems
Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes
There is evidence that female athletes may be more susceptible to exercise-induced arterial hypoxemia and expiratory flow limitation and have greater increases in operational lung volumes during exercise relative to men. These pulmonary limitations may ultimately lead to greater levels of diaphragmatic fatigue in women. Accordingly, the purpose of this study was to determine whether there are sex differences in the prevalence and severity of exercise-induced diaphragmatic fatigue in 38 healthy endurance-trained men (n = 19; maximal aerobic capacity = 64.0 ± 1.9 ml·kg–1·min–1) and women (n = 19; maximal aerobic capacity = 57.1 ± 1.5 ml·kg–1·min–1). Transdiaphragmatic pressure (Pdi) was calculated as the difference between gastric and esophageal pressures. Inspiratory pressure-time products of the diaphragm and esophagus were calculated as the product of breathing frequency and the Pdi and esophageal pressure time integrals, respectively. Cervical magnetic stimulation was used to measure potentiated Pdi twitches (Pdi,tw) before and 10, 30, and 60 min after a constant-load cycling test performed at 90% of peak work rate until exhaustion. Diaphragm fatigue was considered present if there was a 15% reduction in Pdi,tw after exercise. Diaphragm fatigue occurred in 11 of 19 men (58%) and 8 of 19 women (42%). The percent drop in Pdi,tw at 10, 30, and 60 min after exercise in men (n = 11) was 30.6 ± 2.3, 20.7 ± 3.2, and 13.3 ± 4.5%, respectively, whereas results in women (n = 8) were 21.0 ± 2.1, 11.6 ± 2.9, and 9.7 ± 4.2%, respectively, with sex differences occurring at 10 and 30 min (P < 0.05). Men continued to have a reduced contribution of the diaphragm to total inspiratory force output (pressure-time product of the diaphragm/pressure-time product of the esophagus) during exercise, whereas diaphragmatic contribution in women changed very little over time. The findings from this study point to a female diaphragm that is more resistant to fatigue relative to their male counterparts
Surrogate: A Body-Dexterous Mobile Manipulation Robot with a Tracked Base
Robotics platforms in accordance with various embodiments of the invention can be utilized to implement highly dexterous robots capable of whole body motion. Robotics platforms in accordance with one embodiment of the invention include: a memory containing a whole body motion application; a spine, where the spine has seven degrees of freedom and comprises a spine actuator and three spine elbow joints that each include two spine joint actuators; at least one limb, where the at least one limb comprises a limb actuator and three limb elbow joints that each include two limb joint actuators; a tracked base; a connecting structure that connects the at least one limb to the spine; a second connecting structure that connects the spine to the tracked base; wherein the processor is configured by the whole body motion application to move the at least one limb and the spine to perform whole body motion
Calculating Unknown Eigenvalues with a Quantum Algorithm
Quantum algorithms are able to solve particular problems exponentially faster
than conventional algorithms, when implemented on a quantum computer. However,
all demonstrations to date have required already knowing the answer to
construct the algorithm. We have implemented the complete quantum phase
estimation algorithm for a single qubit unitary in which the answer is
calculated by the algorithm. We use a new approach to implementing the
controlled-unitary operations that lie at the heart of the majority of quantum
algorithms that is more efficient and does not require the eigenvalues of the
unitary to be known. These results point the way to efficient quantum
simulations and quantum metrology applications in the near term, and to
factoring large numbers in the longer term. This approach is architecture
independent and thus can be used in other physical implementations
Multiple-Point and Multiple-Time Correlations Functions in a Hard-Sphere Fluid
A recent mode coupling theory of higher-order correlation functions is tested
on a simple hard-sphere fluid system at intermediate densities. Multi-point and
multi-time correlation functions of the densities of conserved variables are
calculated in the hydrodynamic limit and compared to results obtained from
event-based molecular dynamics simulations. It is demonstrated that the mode
coupling theory results are in excellent agreement with the simulation results
provided that dissipative couplings are included in the vertices appearing in
the theory. In contrast, simplified mode coupling theories in which the
densities obey Gaussian statistics neglect important contributions to both the
multi-point and multi-time correlation functions on all time scales.Comment: Second one in a sequence of two (in the first, the formalism was
developed). 12 pages REVTeX. 5 figures (eps). Submitted to Phys.Rev.
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity
Males and females differ in body composition and fat distribution. Using a mouse model that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that XX chromosome complement in combination with a high-fat diet led to enhanced weight gain in the presence of male or female gonads. We identified the genomic dosage of Kdm5c, an X chromosome gene that escapes X chromosome inactivation, as a determinant of the X chromosome effect on adiposity. Modulating Kdm5c gene dosage in XX female mice to levels that are normally present in males resulted in reduced body weight, fat content, and food intake to a degree similar to that seen with altering the entire X chromosome dosage. In cultured preadipocytes, the levels of KDM5C histone demethylase influenced chromatin accessibility (ATAC-Seq), gene expression (RNA-Seq), and adipocyte differentiation. Both in vitro and in vivo, Kdm5c dosage influenced gene expression involved in extracellular matrix remodeling, which is critical for adipocyte differentiation and adipose tissue expansion. In humans, adipose tissue KDM5C mRNA levels and KDM5C genetic variants were associated with body mass. These studies demonstrate that the sex-dependent dosage of Kdm5c contributes to male/female differences in adipocyte biology and highlight X-escape genes as a critical component of female physiology
On the experimental verification of quantum complexity in linear optics
The first quantum technologies to solve computational problems that are
beyond the capabilities of classical computers are likely to be devices that
exploit characteristics inherent to a particular physical system, to tackle a
bespoke problem suited to those characteristics. Evidence implies that the
detection of ensembles of photons, which have propagated through a linear
optical circuit, is equivalent to sampling from a probability distribution that
is intractable to classical simulation. However, it is probable that the
complexity of this type of sampling problem means that its solution is
classically unverifiable within a feasible number of trials, and the task of
establishing correct operation becomes one of gathering sufficiently convincing
circumstantial evidence. Here, we develop scalable methods to experimentally
establish correct operation for this class of sampling algorithm, which we
implement with two different types of optical circuits for 3, 4, and 5 photons,
on Hilbert spaces of up to 50,000 dimensions. With only a small number of
trials, we establish a confidence >99% that we are not sampling from a uniform
distribution or a classical distribution, and we demonstrate a unitary specific
witness that functions robustly for small amounts of data. Like the algorithmic
operations they endorse, our methods exploit the characteristics native to the
quantum system in question. Here we observe and make an application of a
"bosonic clouding" phenomenon, interesting in its own right, where photons are
found in local groups of modes superposed across two locations. Our broad
approach is likely to be practical for all architectures for quantum
technologies where formal verification methods for quantum algorithms are
either intractable or unknown.Comment: Comments welcom
Rewritable nanoscale oxide photodetector
Nanophotonic devices seek to generate, guide, and/or detect light using
structures whose nanoscale dimensions are closely tied to their functionality.
Semiconducting nanowires, grown with tailored optoelectronic properties, have
been successfully placed into devices for a variety of applications. However,
the integration of photonic nanostructures with electronic circuitry has always
been one of the most challenging aspects of device development. Here we report
the development of rewritable nanoscale photodetectors created at the interface
between LaAlO3 and SrTiO3. Nanowire junctions with characteristic dimensions
2-3 nm are created using a reversible AFM writing technique. These nanoscale
devices exhibit a remarkably high gain for their size, in part because of the
large electric fields produced in the gap region. The photoconductive response
is gate-tunable and spans the visible-to-near-infrared regime. The ability to
integrate rewritable nanoscale photodetectors with nanowires and transistors in
a single materials platform foreshadows new families of integrated
optoelectronic devices and applications.Comment: 5 pages, 5 figures. Supplementary Information 7 pages, 9 figure
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