The Multimodal Turing Test for Realistic Humanoid Robots with Embodied Artificial Intelligence

Alan Turing developed the Turing Test as a method to determine whether artificial intelligence (AI) can deceive human interrogators into believing it is sentient by competently answering questions at a confidence rate of 30%+. However, the Turing Test is concerned with natural language processing (NLP) and neglects the significance of appearance, communication and movement. The theoretical proposition at the core of this paper: ‘can machines emulate human beings?’ is concerned with both functionality and materiality. Many scholars consider the creation of a realistic humanoid robot (RHR) that is perceptually indistinguishable from a human as the apex of humanity’s technological capabilities. Nevertheless, no comprehensive development framework exists for engineers to achieve higher modes of human emulation, and no current evaluation method is nuanced enough to detect the causal effects of the Uncanny Valley (UV) effect. The Multimodal Turing Test (MTT) provides such a methodology and offers a foundation for creating higher levels of human likeness in RHRs for enhancing human-robot interaction (HRI

Proceso del cuidado enfermero en una paciente lactante con desnutrición aguda grave y consecuencia infecciosa

Objetivo: Analizar a través de la metodología del proceso enfermero el caso clínico de una niña lactante menor con desnutrición aguda y una consecuencia infecciosa. Caso clínico: Paciente femenina de dos meses de edad, producto de gesta II, por parto eutócico y esquema de vacunación incompleto. En relación con el peso, la talla y la edad la puntuación z se encuentra por debajo del percentil 3. Su alimentación es inadecuada para su edad en relación con los patrones de consumo y contenido nutricional. Presenta hipertermia de 38,4 °C, diarrea al momento de la valoración y estreñimiento como dato histórico, además de cambios negativos en el patrón respiratorio en el momento de la succión y sus padres no atienden las necesidades básicas de acuerdo con su edad. Métodos: Estudio de caso único de enfoque cualitativo, utilizando el marco de valoración de Marjory Gordon y los lenguajes estandarizados NANDA-I, NOC, NIC. Resultados: Se priorizaron 5 diagnósticos enfermeros. Se planeó y ejecutó el plan de cuidados, aunque la evolución de la paciente fue desfavorable, y por la complejidad de su enfermedad, se trasladó a un hospital especializado en atención pediátrica. Conclusiones: La aplicación del plan de cuidados permite un cuidado holístico de las respuestas humanas alteradas identificadas en la paciente y en la familia, que de manera indirecta afectan el estado de salud del infante

Typologies and Features of Play in Mobile Games for Mental Wellbeing

Background: The smartphone market is saturated with apps and games purporting to promote mental wellness. There has been a significant number of studies assessing the impact of these digital interventions. Motivation. The majority of review papers solely focussed on the impact of strict rules and award systems of the apps. There is comparatively little attention paid to other game techniques designed to encourage creativity, a lusory attitude, and playful experiences. Results. This gap is addressed in this paper in a consideration and analysis of a purposive selection of six mobile games marketed for wellbeing, our focus is on both external and internal motivations that these games offer. Our specific interest is how these games balance rule-based play with creativity. We find that ludic play is a highly-structured, rule-bound, goal-oriented play, in contrast to paedic play which a freeform, imaginative, and expressive. We argue that while ludic play is purposed towards the promotion of habit formation and generates feelings of accomplishment, it nonetheless relies heavily on extrinsic motivation to incentivise engagement. By contrast, paidic play, specifically role-playing, improvisation, and the imaginative co-creation of fictional game worlds, can be used effectively in these games to facilitate self-regulation, self-distancing, and therefore provides intrinsically-motivated engagement. In the context of games for mental wellbeing, ludic play challenges players to complete therapeutic exercises, while paidic play offers a welcoming refuge from real world pressures and the opportunity to try on alternate selves. Conclusion: Our intention is not to value paidic play over ludic play, but to consider how these two play modalities can complement and counterbalance each other to generate more effective engagement

Dynamic Profiling of β-Coronavirus 3CL M^proProtease Ligand-Binding Sites

Data availability statement: The trajectories of Mpro simulations and models of the metastable states can be downloaded from 10.5281/zenodo.4782284.β-coronavirus (CoVs) alone has been responsible for three major global outbreaks in the 21st century. The current crisis has led to an urgent requirement to develop therapeutics. Even though a number of vaccines are available, alternative strategies targeting essential viral components are required as a backup against the emergence of lethal viral variants. One such target is the main protease (Mpro) that plays an indispensable role in viral replication. The availability of over 270 Mpro X-ray structures in complex with inhibitors provides unique insights into ligand–protein interactions. Herein, we provide a comprehensive comparison of all nonredundant ligand-binding sites available for SARS-CoV2, SARS-CoV, and MERS-CoV Mpro. Extensive adaptive sampling has been used to investigate structural conservation of ligand-binding sites using Markov state models (MSMs) and compare conformational dynamics employing convolutional variational auto-encoder-based deep learning. Our results indicate that not all ligand-binding sites are dynamically conserved despite high sequence and structural conservation across β-CoV homologs. This highlights the complexity in targeting all three Mpro enzymes with a single pan inhibitor.There was no funding for this wor

A Phase 2, Multicenter, Open-Label Study of Anti-Lag-3 Ieramilimab in Combination With Anti-Pd-1 Spartalizumab in Patients With Advanced Solid Malignancies

Ieramilimab, a humanized anti-LAG-3 monoclonal antibody, was well tolerated in combination with the anti-PD-1 antibody spartalizumab in a phase 1 study. This phase 2 study aimed to further investigate the efficacy and safety of combination treatment in patients with selected advanced (locally advanced or metastatic) solid malignancies. Eligible patients with non-small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), mesothelioma, and triple-negative breast cancer (TNBC) were grouped depending on prior anti-PD-1/L1 therapy (anti-PD-1/L1 naive or anti-PD-1/L1 pretreated). Patients received ieramilimab (400 mg) followed by spartalizumab (300 mg) every 3 weeks. The primary endpoint was objective response rate (ORR), along with safety, pharmacokinetics, and biomarker assessments. Of 235 patients, 142 were naive to anti-PD-1/L1 and 93 were pretreated with anti-PD-1/L1 antibodies. Durable responses (\u3e24 months) were seen across all indications for patients naive to anti-PD-1/L1 and in melanoma and RCC patients pretreated with anti-PD1/L1. The most frequent study drug-related AEs were pruritus (15.5%), fatigue (10.6%), and rash (10.6%) in patients naive to anti-PD-1/L1 and fatigue (18.3%), rash (14.0%), and nausea (10.8%) in anti-PD-1/L1 pretreated patients. Biomarker assessment indicated higher expression of T-cell-inflamed gene signature at baseline among responding patients. Response to treatment was durable (\u3e24 months) in some patients across all enrolled indications, and safety findings were in accordance with previous and current studies exploring LAG-3/PD-1 blockade

Parasitism of Lepidopterous Stem Borers in Cultivated and Natural Habitats

Plant infestation, stem borer density, parasitism, and parasitoid abundance were assessed during two years in two host plants, Zea mays (L.) (Cyperales: Poaceae) and Sorghum bicolor (L.) (Cyperales: Poaceae), in cultivated habitats. The four major host plants (Cyperus spp., Panicum spp., Pennisetum spp., and Sorghum spp.) found in natural habitats were also assessed, and both the cultivated and natural habitat species occurred in four agroecological zones in Kenya. Across habitats, plant infestation (23.2%), stem borer density (2.2 per plant), and larval parasitism (15.0%) were highest in maize in cultivated habitats. Pupal parasitism was not higher than 4.7% in both habitats, and did not vary with locality during each season or with host plant between each season. Cotesia sesamiae (Cameron) and C. flavipes Cameron (Hymenoptera: Braconidae) were the key parasitoids in cultivated habitats (both species accounted for 76.4% of parasitized stem borers in cereal crops), but not in natural habitats (the two Cotesia species accounted for 14.5% of parasitized stem borers in wild host plants). No single parasitoid species exerted high parasitism rates on stem borer populations in wild host plants. Low stem borer densities across seasons in natural habitats indicate that cereal stem borer pests do not necessarily survive the non-cropping season feeding actively in wild host plants. Although natural habitats provided refuges for some parasitoid species, stem borer parasitism was generally low in wild host plants. Overall, because parasitoids contribute little in reducing cereal stem borer pest populations in cultivated habitats, there is need to further enhance their effectiveness in the field to regulate these pests