On the Measurements of Individual Particle Properties Via Compression and Crushing

An experimental study is presented to measure the elastic, yielding, and crushing properties of individual particles under compression using substrates made of aluminum alloy, stainless steel, and sapphire. Carefully selected, highly spherical individual Ottawa sand particles of 0.75-1.1 mm in nominal diameter were compressed between two smooth substrates, and the load-deformation curves were analyzed by Hertz elastic contact theory to derive their reduced modulus and Young\u27s modulus as well as yielding and crushing strengths, which vary significantly with the type of substrate materials. Further analysis of the yielding and plastic deformation at the particle-substrate contact shows that the yield strength or hardness of the substrate materials dominates the local contact behavior and hence affects the measured apparent yielding and crushing strengths. The two softer substrates (aluminum alloy and stainless steel) actually lead to underestimated apparent shear yield strengths of quartz particles by 60.4% and 54.2%, respectively, which are actually the yielding of substrates, while the true particle yielding occurs in the sapphire-particle contact. Moreover, the two softer substrates cause much overestimated crushing strengths of the quartz particles by 50.4% and 36.4%, respectively. Selection of inappropriate substrate materials and inappropriate interpretation of the particle-substrate contact can lead to significant errors in the measured yielding and crushing strengths. It is recommended that single particle compression testing uses substrates with yield strength greater than that of the tested particles and result interpretation also considers the elastic and yielding behaviors of the substrates. (C) 2021 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting by Elsevier B.V

A nomogram based on CT intratumoral and peritumoral radiomics features preoperatively predicts poorly differentiated invasive pulmonary adenocarcinoma manifesting as subsolid or solid lesions: a double-center study

BackgroundThe novel International Association for the Study of Lung Cancer (IASLC) grading system suggests that poorly differentiated invasive pulmonary adenocarcinoma (IPA) has a worse prognosis. Therefore, prediction of poorly differentiated IPA before treatment can provide an essential reference for therapeutic modality and personalized follow-up strategy. This study intended to train a nomogram based on CT intratumoral and peritumoral radiomics features combined with clinical semantic features, which predicted poorly differentiated IPA and was tested in independent data cohorts regarding models’ generalization ability.MethodsWe retrospectively recruited 480 patients with IPA appearing as subsolid or solid lesions, confirmed by surgical pathology from two medical centers and collected their CT images and clinical information. Patients from the first center (n =363) were randomly assigned to the development cohort (n = 254) and internal testing cohort (n = 109) in a 7:3 ratio; patients (n = 117) from the second center served as the external testing cohort. Feature selection was performed by univariate analysis, multivariate analysis, Spearman correlation analysis, minimum redundancy maximum relevance, and least absolute shrinkage and selection operator. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate the model performance.ResultsThe AUCs of the combined model based on intratumoral and peritumoral radiomics signatures in internal testing cohort and external testing cohort were 0.906 and 0.886, respectively. The AUCs of the nomogram that integrated clinical semantic features and combined radiomics signatures in internal testing cohort and external testing cohort were 0.921 and 0.887, respectively. The Delong test showed that the AUCs of the nomogram were significantly higher than that of the clinical semantic model in both the internal testing cohort(0.921 vs 0.789, p< 0.05) and external testing cohort(0.887 vs 0.829, p< 0.05).ConclusionThe nomogram based on CT intratumoral and peritumoral radiomics signatures with clinical semantic features has the potential to predict poorly differentiated IPA manifesting as subsolid or solid lesions preoperatively

Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers

ABSTRACT Adamantanes (amantadine and rimantadine) are one of the two classes of Food and Drug Administration-approved antiviral drugs used for the prevention and treatment of influenza A virus infections. They inhibit viral replication by blocking the wild-type (WT) M2 proton channel, thus preventing viral uncoating. However, their use was discontinued due to widespread drug resistance. Among a handful of drug-resistant mutants, M2-S31N is the predominant mutation and persists in more than 95% of currently circulating influenza A strains. We recently designed two classes of M2-S31N inhibitors, S31N-specific inhibitors and S31N/WT dual inhibitors, which are represented by N-[(5-cyclopropyl-1,2-oxazol-3-yl)methyl]adamantan-1-amine (WJ379) and N-[(5-bromothiophen-2-yl)methyl]adamantan-1-amine (BC035), respectively. However, their antiviral activities against currently circulating influenza A viruses and their genetic barrier to drug resistance are unknown. In this report, we evaluated the therapeutic potential of these two classes of M2-S31N inhibitors (WJ379 and BC035) by profiling their antiviral efficacy against multidrug-resistant influenza A viruses, in vitro drug resistance barrier, and synergistic effect with oseltamivir. We found that M2-S31N inhibitors were active against several influenza A viruses that are resistant to one or both classes of Food and Drug Administration-approved anti-influenza drugs. In addition, M2-S31N inhibitors display a higher in vitro genetic barrier to drug resistance than amantadine. The antiviral effect of WJ379 was also synergistic with oseltamivir carboxylate. Overall, these results reaffirm that M2-S31N inhibitors are promising antiviral drug candidates that warrant further development

Comparisons of blood biochemical parameters, digestive enzyme activities and volatile fatty acid profile between Meishan and Yorkshire piglets

This study was conducted to compare physiological characteristics between Meishan and Yorkshire piglets in their early lives. Six healthy purebred Meishan sows and Yorkshire sows with close farrowing dates were used in this research. The piglets sucked their respective sow's milk for 14 days, then they were slaughtered to collect samples of blood, pancreas, contents of stomach, jejunum, cecum, colon as well as feces for analysis of blood biochemical parameters, digestive enzymes, and volatile fatty acid (VFA). The results showed that Yorkshire piglets had higher concentrations of high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) (P < 0.05). Gastric lipase activity was higher in Meishan piglets but Yorkshire piglets had higher lactase activity (P < 0.05). The total VFA together with acetate and propionate in cecum and colon were higher in Meishan piglets than in Yorkshire piglets (P < 0.05), but acetate in jejunum and ratio of acetate to propionate in colon were lower in Meishan piglets than in Yorkshire piglets (P < 0.05). In conclusion, in early suckling period, significant differences exist in host metabolism and intestinal microbial metabolism between Meishan and Yorkshire piglets

A New Measurement Based on HPB to Measure the Wall Pressure of Electric-Spark-Generated Bubble near the Hemispheric Boundary

Direct measurement of the wall pressure loading of the spherical boundary subjected to the near-field underwater explosion is a great difficulty. To investigate the wall pressure caused by electric-spark-generated bubble near a hemispheric boundary, an experiment system is developed. In the method of this experiment, a Hopkinson bar (HPB), used as the sensing element, is inserted through the hole drilled on the hemisphere target and the bar’s measuring end face lies flush with the loaded face of the hemisphere target to detect and record the pressure loading. The semiconductor strain gauges which stick on Hopkinson bar are used to convert the pressure-based signal to the strain wave signal. The bubble in the experiments is formed by a discharge of 400 V high voltage. To validate the pressure measurement technique based on the HPB, an experimental result from pressure transducer is used as the validating system. To verify the capability of this new methodology and experimental system, a series of electric-spark-generated bubble experiments are conducted. From the recorded pressure-time profiles coupled with the underwater explosion evolution images captured by the high-speed camera (HSV), the shock wave pressure loading and bubble collapse pressure loadings are captured in detail at different dimensionless stand-off distances γ from 0.17 to 2.00. From the results of the experiments conducted in this paper, the proposed experiment system can be used to measure the pressure signal successfully, giving new way to study the bubble collapse pressure when the bubble is near a hemispheric boundary. Through the experimental results, the bubbles generated by different dimensionless stand-off distance γ are divided into four categories, and the bubble load characteristics are also discussed

Free Vibration Analysis of Closed Moderately Thick Cross-Ply Composite Laminated Cylindrical Shell with Arbitrary Boundary Conditions

A semi-analytic method is adopted to analyze the free vibration characteristics of the moderately thick composite laminated cylindrical shell with arbitrary classical and elastic boundary conditions. By Hamilton&rsquo;s principle and first-order shear deformation theory, the governing equation of the composite shell can be established. The displacement variables are transformed into the wave function forms to ensure the correctness of the governing equation. Based on the kinetic relationship between the displacement variables and force resultants, the final equation associated with arbitrary boundary conditions is established. The dichotomy method is conducted to calculate the natural frequencies of the composite shell. For verifying the correctness of the present method, the results by the present method are compared with those in the pieces of literatures with various boundary conditions. Furthermore, some numerical examples are calculated to investigate the effect of several parameters on the composite shell, such as length to radius ratios, thickness to radius ratios and elastic restrained constants