High mortality rates in men initiated on anti-retroviral treatment in KwaZulu-Natal, South Africa.

CAPRISA, 2017.Abstract available in pdf

US/Caribbean relationships: Perspectives from Caribbean Psychology and Mainstream Social Psychology

A disproportionately high percentage of relationship studies have focused on the experiences of couples in which both partners are from the United States (Goodwin, 1999) and are of European descent (Gaines, Buriel, Liu, & Rios, 1997). Persons from developing countries, such as those comprising the Caribbean, have been grossly underrepresented in the field of personal relationships. In this chapter, we first give an overview of some of the research related to interpersonal relationships that has been conducted in the Caribbean, especially in Jamaica. Despite the possibility of pan-cultural similarities in personal relationship processes, a crosscultural perspective is important to show differences as well as similarities between Americans and persons of various ethnicities and races from the Caribbean. We also apply social exchange theory to the study of Caribbean relationships in particular, as this theory provides a useful framework for understanding both Black Americans and Caribbeans in relation to European descendants in the United States. Finally, areas for future research are suggested.https://www.taylorfrancis.com/chapters/edit/10.4324/9780203843789-21/caribbean-couples-perspectives-caribbean-psychology-mainstream-social-psychology-stanley-gaines-jr-marina-ramkissoon?context=ubx&refId=e426cfc2-b1e6-4919-9bd9-0d5c99d95a6

MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism

Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs including 19 Angiocentric Gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in Angiocentric Gliomas. In vitro and in vivo functional studies show MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression, and hemizygous loss of the tumor suppressor QKI. This represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor