10 research outputs found
Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria
Get PDFQuantitation of glutathione S-transferases in rice (Oryza sativa L.) roots exposed to cadmium by liquid chromatography–tandem mass spectrometry using isotope-labeled wing peptides as an internal standard
No full textHeteroatom(isotope)-tagged proteomics via ICP-MS: screening and quantification of proteins and their post-translational modifications
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Identification and detection sensitivity of Microcystis aeruginosa from mixed and field samples using MALDI-TOF MS
No full textApplying Ligands Profiling Using Multiple Extended Electron Distribution Based Field Templates and Feature Trees Similarity Searching in the Discovery of New Generation of Urea-Based Antineoplastic Kinase Inhibitors
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Functional proteomics to dissect tyrosine kinase signalling pathways in cancer
Get PDFAdvances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics
