6 research outputs found
Laser spectroscopy for breath analysis : towards clinical implementation
Detection and analysis of volatile compounds in exhaled breath represents an attractive tool for monitoring the metabolic status of a patient and disease diagnosis, since it is non-invasive and fast. Numerous studies have already demonstrated the benefit of breath analysis in clinical settings/applications and encouraged multidisciplinary research to reveal new insights regarding the origins, pathways, and pathophysiological roles of breath components. Many breath analysis methods are currently available to help explore these directions, ranging from mass spectrometry to laser-based spectroscopy and sensor arrays. This review presents an update of the current status of optical methods, using near and mid-infrared sources, for clinical breath gas analysis over the last decade and describes recent technological developments and their applications. The review includes: tunable diode laser absorption spectroscopy, cavity ring-down spectroscopy, integrated cavity output spectroscopy, cavity-enhanced absorption spectroscopy, photoacoustic spectroscopy, quartz-enhanced photoacoustic spectroscopy, and optical frequency comb spectroscopy. A SWOT analysis (strengths, weaknesses, opportunities, and threats) is presented that describes the laser-based techniques within the clinical framework of breath research and their appealing features for clinical use.Peer reviewe
Study on long-wave infrared ZnGeP2 subsequent optical parametric amplifiers with different types of phase matching of ZnGeP2 crystals
A Kind of Broadband Polarization Filter Based on Photonic Crystal Fiber with Nanoscale Gold Film
Massively parallel sensing of trace molecules and their isotopologues with broadband subharmonic mid-infrared frequency combs
We use a pair of mutually-coherent frequency-divide-by-two (subharmonic) GaAs OPOs with instantaneous span 3.1-5.5µm to demonstrate fast acquisition of 350,000 mode-resolved spectral data points and perform parallel detection in a mixture of 22 molecular species