The alcohol purchase task in young men from the general population.

BACKGROUND: The alcohol purchase task (APT), which presents a scenario and asks participants how many drinks they would purchase and consume at different prices, has been used among students and small clinical samples to obtain measures of alcohol demand but not in large, general population samples. METHODS: We administered the APT to a large sample of young men from the general population (Cohort Study on Substance Use Risk Factors). Participants who reported drinking in the past year (n=4790), reported on past 12 months alcohol use, on DSM-5 alcohol use disorder (AUD) criteria and on alcohol related consequences were included. RESULTS: Among the APT's demand parameters, intensity was 8.7 (SD=6.5) indicating that, when drinks are free, participants report a planned consumption of almost 9 drinks. The maximum alcohol expenditure (Omax) was over 35CHF (1CHF=1.1USD) and the demand became elastic (Pmax) at 8.4CHF (SD=5.6). The mean price at which the consumption was suppressed was 15.6CHF (SD=5.4). Exponential equation provided a satisfactory fit to individual responses (mean R(2): 0.8, median: 0.8). Demand intensity was correlated with alcohol use, number of AUD criteria and number of consequences (all r≥0.3, p<0.0001). Omax was correlated with alcohol use (p<0.0001). The elasticity parameter was weakly correlated with alcohol use in the expected direction. CONCLUSION: The APT measures are useful in characterizing demand for alcohol in young men in the general population. Demand may provide a clinically useful index of strength of motivation for alcohol use in general population samples

La tiranía de la flor de la vida en la economía de Aristóteles

El artículo intenta dar una explicación del tratamiento despectivo que Aristóteles da a la niñez. Comienza recordando que la oikonomia de Aristóteles se ocupa principalmente de "la perfección moral e intelectual de los miembros de la casa, no de su adquirir y gastar". Murphy señala que Aristóteles confiere al padre, dada su madurez, no sólo una primacía en su autoridad sino una tiranía sobre los niños (y también sobre los ancianos).-----The paper focuses on giving an explanation to Aristotle’s dismissal treatment of childhood. The paper begins recalling us that Aristotle's oikonomia is mainly about "the moral and intellectual perfection of the members of the household, not about getting and spending". It notes that Aristotle confers to the father, living his prime of life, not only a primacy but also a tyrannic authority over the children (and also over the elderly)

Longitudinal potential well distortion due to the synchrotron radiation wakefield

The effect of the synchrotron radiation free space wakefield on the equilibrium bunch length in an electron storage ring is explored. The equilibrium bunch length, which is obtained numerically, is shown to increase for {alpha}O

Modification of the pattern informatics method for forecasting large earthquake events using complex eigenvectors

Recent studies have shown that real-valued principal component analysis can be applied to earthquake fault systems for forecasting and prediction. In addition, theoretical analysis indicates that earthquake stresses may obey a wave-like equation, having solutions with inverse frequencies for a given fault similar to those that characterize the time intervals between the largest events on the fault. It is therefore desirable to apply complex principal component analysis to develop earthquake forecast algorithms. In this paper we modify the Pattern Informatics method of earthquake forecasting to take advantage of the wave-like properties of seismic stresses and utilize the Hilbert transform to create complex eigenvectors out of measured time series. We show that Pattern Informatics analyses using complex eigenvectors create short-term forecast hot-spot maps that differ from hot-spot maps created using only real-valued data and suggest methods of analyzing the differences and calculating the information gain.Comment: 13 pages, 1 figure. Submitted to Tectonophysics on 30 August 200

Cortical Structure and Cognition in Infants and Toddlers

Cortical structure has been consistently related to cognitive abilities in children and adults, yet we know little about how the cortex develops to support emergent cognition in infancy and toddlerhood when cortical thickness (CT) and surface area (SA) are maturing rapidly. In this report, we assessed how regional and global measures of CT and SA in a sample (N = 487) of healthy neonates, 1-year-olds, and 2-year-olds related to motor, language, visual reception, and general cognitive ability. We report novel findings that thicker cortices at ages 1 and 2 and larger SA at birth, age 1, and age 2 confer a cognitive advantage in infancy and toddlerhood. While several expected brain-cognition relationships were observed, overlapping cortical regions were also implicated across cognitive domains, suggesting that infancy marks a period of plasticity and refinement in cortical structure to support burgeoning motor, language, and cognitive abilities. CT may be a particularly important morphological indicator of ability, but its impact on cognition is relatively weak when compared with gestational age and maternal education. Findings suggest that prenatal and early postnatal cortical developments are important for cognition in infants and toddlers but should be considered in relation to other child and demographic factors

Experimental Investigation of Superradiance in a Tapered Free-Electron Laser Amplifier

We report experimental studies of the effect of undulator tapering on superradiance in a single-pass high-gain free-electron laser (FEL) amplifier. The experiments were performed at the Source Development Laboratory (SDL) of National Synchrotron Light Source (NSLS). Efficiency was nearly tripled with tapering. Both the temporal and spectral properties of the superradiant FEL along the uniform and tapered undulator were experimentally characterized using frequency-resolved optical gating (FROG) images. Numerical studies predicted pulse broadening and spectral cleaning by undulator tapering Pulse broadening was experimentally verified. However, spectral cleanliness degraded with tapering. We have performed first experiments with a tapered undulator and a short seed laser pulse. Pulse broadening with tapering expected from simulations was experimentally confirmed. However, the experimentally obtained spectra degraded with tapering, whereas the simulations predicted improvement. A further numerical study is under way to resolve this issue

Genetic influences on neonatal cortical thickness and surface area

Genetic and environmental influences on cortical thickness (CT) and surface area (SA) are thought to vary in a complex and dynamic way across the lifespan. It has been established that CT and SA are genetically distinct in older children, adolescents, and adults, and that heritability varies across cortical regions. Very little, however, is known about how genetic and environmental factors influence infant CT and SA. Using structural MRI, we performed the first assessment of genetic and environmental influences on normal variation of SA and CT in 360 twin neonates. We observed strong and significant additive genetic influences on total SA (a2 = 0.78) and small and nonsignificant genetic influences on average CT (a2 = 0.29). Moreover, we found significant genetic overlap (genetic correlation = 0.65) between these global cortical measures. Regionally, there were minimal genetic influences across the cortex for both CT and SA measures and no distinct patterns of genetic regionalization. Overall, outcomes from this study suggest a dynamic relationship between CT and SA during the neonatal period and provide novel insights into how genetic influences shape cortical structure during early development

Generation of Tunable Narrowband Terahertz Pulses from Coherent Transition Radiation

N/