833 research outputs found
Buying Design, Where are we now? Associate Parliamentary Design Innovation Group Term Paper
‘Design ...The purposeful move from a current situation to a preferred situation.’ – Herbert Simon
In 2010 the Associate Parliamentary Design and Innovation Group (APDIG) published a report critiquing government procurement practice as it related to design services. The main accusation was that government too often tried to buy design as though it were a discrete commodity, rather than a creative service, and that this seriously hampered the ultimate outcome for both buyer and supplier. This paper brings an update on the state of design procurement, including the results of an industry consultation conducted by our partners on the initial report, the Design Business Association
The host galaxies of strong CaII QSO absorption systems at z<0.5
We present new imaging and spectroscopic observations of the fields of five
QSOs with very strong intervening CaII absorption systems at redshifts z<0.5
selected from the Sloan Digital Sky Survey. Recent studies of these very rare
absorbers indicate that they may be related to damped Lyman alpha systems
(DLAs). In all five cases we identify a galaxy at the redshift of the CaII
system with impact parameters up to ~24 kpc. In four out of five cases the
galaxies are luminous (L ~L*), metal-rich (Z ~Zsun), massive (velocity
dispersion, sigma ~100 km/s) spirals. Their star formation rates, deduced from
Halpha emission, are high, in the range SFR = 0.3 - 30 Msun/yr. In our
analysis, we paid particular attention to correcting the observed emission line
fluxes for stellar absorption and dust extinction. We show that these effects
are important for a correct SFR estimate; their neglect in previous low-z
studies of DLA-selected galaxies has probably led to an underestimate of the
star formation activity in at least some DLA hosts. We discuss possible links
between CaII-selected galaxies and DLAs and outline future observations which
will help clarify the relationship between these different classes of QSO
absorbers.Comment: Accepted for publication in MNRAS, 14 pages, 9 figures. Version with
full resolution images available at
http://www.ast.cam.ac.uk/~bjz/papers/Zych_etal_2007a.pd
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Marginalisation, Young People in the South and East Mediterranean and Policy: An Analysis of Young People's Experiences of Marginalisation Across Sex SEM Countries and Guidelines for Policy Makers
PARMELA VS MEASUREMENTS FOR GTF AND DUVFEL
The particle-pushing PARMELA was used to design the photo-injector beamline of the Linac Coherent Light Source (LCLS) to be built at SLAC in 2005. PARMELA predicts that projected emittances smaller than 1.2 mm.mrad and slice emittance smaller than 1.0 mm.mrad will be achievable for 1nC, 10ps electron bunches with an S-band RF gun and an emittance compensating system. To benchmark PARMELA, comparisons between simulations and measurements for two photo-injector test facilities, the Gun Test Facility (GTF) at SLAC and the Deep Ultra Violet FEL (DUVFEL) at BNL, have been performed. Aspects of the modeling of fields and initial distributions are discussed. The agreement between measured and simulated beam parameters (projected and slice emittance, Twiss parameters) is satisfying. Accordingly, it gives credibility to the extrapolation made for studying the LCLS case. PARMELA also indicates possible improvements in the tuning of those facilities to achieve the LCLS required beam properties.
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2
SHIP1, an inositol 5-phosphatase, plays a central role in cellular signaling. As such, it has been implicated in many conditions. Exploiting SHIP1 as a drug target will require structural knowledge and the design of selective small molecules. We have determined apo, and magnesium and phosphate-bound structures of the phosphatase and C2 domains of SHIP1. The C2 domains of SHIP1 and the related SHIP2 modulate the activity of the phosphatase domain. To understand the mechanism, we performed activity assays, hydrogen-deuterium exchange mass spectrometry, and molecular dynamics on SHIP1 and SHIP2. Our findings demonstrate that the influence of the C2 domain is more pronounced for SHIP2 than SHIP1. We determined 91 structures of SHIP1 with fragments bound, with some near the interface between the two domains. We performed a mass spectrometry screen and determined four structures with covalent fragments. These structures could act as starting points for the development of potent, selective probes
Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates
We investigated the impact of parenteral antibiotic treatment in the early neonatal period on the evolution of bifidobacteria in the newborn. Nine babies treated with intravenous ampicillin/gentamicin in the first week of life and nine controls (no antibiotic treatment) were studied. Denaturing gradient gel electrophoresis was used to investigate the composition of Bifidobacterium in stool samples taken at four and eight weeks. Bifidobacteria were detected in all control infants at both four and eight weeks, while only six of nine antibiotic-treated infants had detectable bifidobacteria at four weeks and eight of nine at eight weeks. Moreover, stool samples of controls showed greater diversity of Bifidobacterium spp. compared with antibiotic-treated infants. In conclusion, short-term parenteral antibiotic treatment of neonates causes a disturbance in the expected colonization pattern of bifidobacteria in the first months of life. Further studies are required to probiotic determine if supplementation is necessary in this patient group
The experience of family carers attending a joint reminiscence group with people with dementia: A thematic analysis
Reminiscence therapy has the potential to improve quality of life for people with dementia. In recent years reminiscence groups have extended to include family members, but carers' experience of attending joint sessions is undocumented. This qualitative study explored the experience of 18 family carers attending 'Remembering Yesterday Caring Today' groups. Semi-structured interviews were transcribed and subjected to thematic analysis. Five themes were identified: experiencing carer support; shared experience; expectations (met and unmet), carer perspectives of the person with dementia's experience; and learning and comparing. Family carers' experiences varied, with some experiencing the intervention as entirely positive whereas others had more mixed feelings. Negative aspects included the lack of respite from their relative, the lack of emphasis on their own needs, and experiencing additional stress and guilt through not being able to implement newly acquired skills. These findings may explain the failure of a recent trial of joint reminiscence groups to replicate previous findings of positive benefit. More targeted research within subgroups of carers is required to justify the continued use of joint reminiscence groups in dementia care
EMI and Beyond
This collection presents the state of the art on English-medium instruction (EMI) / Integrating content and language (ICL) in Italian higher education, drawing attention to different critical aspects of the teaching/learning experience and highlighting the perspectives of various educational stakeholders regarding the effectiveness of tertiary study in a foreign language. The chapters draw on a range of methodologies, from multimodal participant observation, to action research, to video-stimulated recall (VSR), to questionnaires and interviews, in examining language policies and practices across various educational settings. Overall, the volume suggests that internationalisation succeeds best when the form of lessons (language) and the content of lessons (disciplinary concepts) are constructively aligned in curriculum planning and delivery. This integration process requires the strategic support of educators to guarantee the quality of learning in multilingual education.
Performance of a non-invasive test for detecting mycobacterium bovis shedding in European badger (meles meles) populations
The incidence of Mycobacterium bovis, the causative agent of bovine tuberculosis, in cattle herds in the United Kingdom is increasing, resulting in substantial economic losses. The European badger (Meles meles) is implicated as a wildlife reservoir and is the subject of control measures aimed at reducing incidence in cattle populations. Understanding the epidemiology of M. bovis in badger populations is essential to direct control interventions and understand disease spread; however, accurate diagnosis in live animals is challenging and currently uses invasive methods. Here we present a non-invasive diagnostic procedure and sampling regime using field sampling of latrines and detection of M. bovis with qPCR, the results of which strongly correlate with the results of immunoassay testing in the field at the social group level. This method allows M. bovis infection in badger populations to be monitored without trapping and provides additional information on the quantity of bacterial DNA shed. Our approach may therefore provide valuable insights into the epidemiology of bovine tuberculosis in badger populations and inform disease control interventions
Corrigendum to “Effects of therapeutic hypothermia on the gut microbiota and metabolome of infants suffering hypoxic-ischemic encephalopathy at birth” [Int. J. Biochem. Cell Biol. 93 (December) (2017), 110-118]
peer-reviewedCorrigendum Refers to:
Watkins, C., Murphy, K., Yen, S., Carafa, I., Dempsey, E., O’Shea, C., Vercoe, E., Ross, R., Stanton, C. and Ryan, C. (2017). Effects of therapeutic hypothermia on the gut microbiota and metabolome of infants suffering hypoxic-ischemic encephalopathy at birth. The International Journal of Biochemistry & Cell Biology, [online] 93, pp.110-118. Available at: https://doi.org/10.1016/j.biocel.2017.08.01
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