7 research outputs found
Correlation between functional capacity and health-related quality of life in COPD: a case series
Serotonin 5-HT4 receptors and forebrain cholinergic system: receptor expression in identified cell populations
Stomatal closure is induced by hydraulic signals and maintained by ABA in drought-stressed grapevine
8noWater saving under drought stress is assured by stomatal closure driven by active (ABA-mediated) and/or passive (hydraulic-mediated) mechanisms. There is currently no comprehensive model nor any general consensus about the actual contribution and relative importance of each of the above factors in modulating stomatal closure in planta. In the present study, we assessed the contribution of passive (hydraulic) vs active (ABA mediated) mechanisms of stomatal closure in V. vinifera plants facing drought stress. Leaf gas exchange decreased progressively to zero during drought, and embolism-induced loss of hydraulic conductance in petioles peaked to ∼50% in correspondence with strong daily limitation of stomatal conductance. Foliar ABA significantly increased only after complete stomatal closure had already occurred. Rewatering plants after complete stomatal closure and after foliar ABA reached maximum values did not induced stomatal re-opening, despite embolism recovery and water potential rise. Our data suggest that in grapevine stomatal conductance is primarily regulated by passive hydraulic mechanisms. Foliar ABA apparently limits leaf gas exchange over long-term, also preventing recovery of stomatal aperture upon rewatering, suggesting the occurrence of a mechanism of long-term down-regulation of transpiration to favor embolism repair and preserve water under conditions of fluctuating water availability and repeated drought events.openopenTombesi, Sergio; Nardini, Andrea; Frioni, Tommaso; Soccolini, Marta; Zadra, Claudia; Farinelli, Daniela; Poni, Stefano; Palliotti, AlbertoTombesi, Sergio; Nardini, Andrea; Frioni, Tommaso; Soccolini, Marta; Zadra, Claudia; Farinelli, Daniela; Poni, Stefano; Palliotti, Albert
Stomatal closure is induced by hydraulic signals and maintained by ABA in drought-stressed grapevine
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Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons
In mood disorders, psychomotor and sensory abnormalities are prevalent, disabling, and intertwined with emotional and cognitive symptoms. Corticostriatal neurons in motor and somatosensory cortex are implicated in these symptoms, yet mechanisms of their vulnerability are unknown. Here, we demonstrate that S100a10 corticostriatal neurons exhibit distinct serotonin responses and have increased excitability, compared with S100a10-negative neurons. We reveal that prolonged social isolation disrupts the specific serotonin response which gets restored by chronic antidepressant treatment. We identify cell-type-specific transcriptional signatures in S100a10 neurons that contribute to serotonin responses and strongly associate with psychomotor and somatosensory function. Our studies provide a strong framework to understand the pathogenesis and create new avenues for the treatment of mood disorders
Widespread horse-based mobility arose around 2,200 BCE in Eurasia
This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this recordData availability:All collapsed and paired-end sequence data for samples sequenced in this study are available in compressed
FASTQ format through the European Nucleotide Archive under accession number PRJEB71445, together
with rescaled and trimmed bam sequence alignments against the nuclear horse reference genomes.
Previously published ancient data used in this study are available under accession numbers PRJEB7537,
PRJEB10098, PRJEB10854, PRJEB22390, PRJEB31613, and PRJEB44430, and detailed in Supplementary
Table 1. The genomes of 78 modern horses, publicly available, were also accessed as indicated in their
corresponding original publications, and in Supplementary Table 1.Code availability: The software to calculate generation time changes based on the recombination clock is available without
restriction on Bitbucket (https://bitbucket.org/plibradosanz/generationtime/src/master/) and Zenodo
(10.5281/zenodo.10842666; https://zenodo.org/records/10842666)Horses revolutionized human history with fast mobility. However, the timeline between their domestication and widespread integration as a means of transportation remains contentious. Here we assemble a large collection of 475 ancient horse genomes to assess the period when these animals were first reshaped by human agency in Eurasia. We find that reproductive control of the modern domestic lineage emerged ~2,200 BCE (Before Common Era), through close kin mating and shortened generation times. Reproductive control emerged following a severe domestication bottleneck starting no earlier than ~2,700 BCE, and coincided with a sudden expansion across Eurasia that ultimately resulted in the replacement of nearly every local horse lineage. This expansion marked the rise of widespread horse-based mobility in human history, which refutes the commonly-held narrative of large horse herds accompanying the massive migration of steppe peoples across Europe ~3,000 BCE and earlier. Finally, we detect significantly shortened generation times at Botai ~3,500 BCE, a settlement from Central Asia associated with corrals and a subsistence economy centered on horses. This supports local horse husbandry before the rise of modern domestic bloodlines.Arts and Humanities Research Council (AHRC