4 research outputs found
HP1a Targets the Drosophila KDM4A Demethylase to a Subset of Heterochromatic Genes to Regulate H3K36me3 Levels
- Author
- AA Joshi
- AC Spradling
- AC Spradling
- AJ Bannister
- AM Johansson
- Ariel Paulson
- BD Fodor
- BY Lu
- C Dinant
- CD Smith
- CH Lin
- Chia-Hui Lin
- CY Liang
- D Zhang
- DE Cryderman
- DE Cryderman
- DJ Bua
- DK Pokholok
- E de Wit
- E de Wit
- E Larschan
- EC mod
- F De Lucia
- G Hon
- I Chiolo
- J Zeitlinger
- JC Eissenberg
- Jerry L. Workman
- JR Danzer
- JR Whetstine
- K Agger
- L Fanti
- L Hillringhaus
- L Piacentini
- M Kawazu
- M Lloret-Llinares
- M Markstein
- M Schwaiger
- Mary Bryk
- MC Keogh
- MJ Carrozza
- MS Luijsterburg
- MT Lorbeck
- N Iwamori
- NC Riddle
- O Bell
- P Dhami
- P Kolasinska-Zwierz
- P Trojer
- PA Cloos
- PA Cloos
- R Andersson
- R Edgar
- RA Hoskins
- RF Luco
- RJ Klose
- RJ Klose
- S Chantalat
- SH Kwon
- Susan M. Abmayr
- T Jenuwein
- T Kim
- T Kouzarides
- T Sandmann
- TC James
- TI Lee
- Y Huang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However, the genome-wide distribution of KDM4 proteins and the mechanism of genomic-targeting remain elusive. We have previously identified Drosophila KDM4A (dKDM4A) as a histone H3K36me3 demethylase that directly interacts with HP1a. Here, we performed H3K36me3 ChIP-chip analysis in wild type and dkdm4a mutant embryos to identify genes regulated by dKDM4A demethylase activity in vivo. A subset of heterochromatic genes that show increased H3K36me3 levels in dkdm4a mutant embryos overlap with HP1a target genes. More importantly, binding to HP1a is required for dKDM4A-mediated H3K36me3 demethylation at a subset of heterochromatic genes. Collectively, these results show that HP1a functions to target the H3K36 demethylase dKDM4A to heterochromatic genes in Drosophila
Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells
- Author
- A Baba
- A Chawla
- A Patel
- A Shukla
- AG Cristancho
- AI Caplan
- AJ Bannister
- AV Krivtsov
- AW James
- B Beck
- BD Strahl
- BD Yu
- C Faust
- C Johansson
- C Lu
- C Martin
- CC Johnston Jr
- Christine Hong
- Cun-Yu Wang
- D Karachentsev
- D O'Carroll
- D Pasini
- D Pasini
- D Pasini
- D Schwarz
- EJ Moerman
- EV Benevolenskaya
- F Lan
- F Lu
- G Alvarez
- G Ren
- GL Lin
- H Oda
- H Wang
- H Wu
- I Takada
- J Chang
- J Chang
- J Christensen
- J Dragojevič
- J Du
- J He
- J Lee
- J Min
- J Vandamme
- J Xu
- JE Dodge
- JJ Minguell
- K Wakabayashi
- KA Lawson
- KB Shpargel
- KM Sinha
- KM Sinha
- Kyung-Eun Lim
- L Guo
- L Verrier
- L Wang
- L Yang
- L Ye
- M Dominici
- M Kawazu
- MT Lorbeck
- MT Pedersen
- MT Pedersen
- N Iwamori
- N Lopez-Bigas
- O Binda
- O Binda
- P Bianco
- Peng Deng
- PH Strobl-Mazzulla
- Qian-Ming Chen
- R Dong
- R Gao
- R Marmorstein
- R Terranova
- R Yasuda
- RJ Klose
- RJ Klose
- RM Labbé
- S Dambacher
- S Hemming
- S Lee
- S Ma
- S Seenundun
- T Burgold
- T Fukuda
- T Hoshiba
- T Jenuwein
- T Satoh
- T Tonini
- VG Allfrey
- VV Lunyak
- W Fischle
- W Ge
- W Liu
- X Shen
- Y Okuno
- Y Shi
- Y Shi
- Y Tao
- Y Tsukada
- Y Wei
- YA Romanov
- YB Schwartz
- YH Chen
- YW Cho
- Z Fan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/10/2015
- Field of study
Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and differentiation potential into multiple tissues. Thus, management of the differentiation capacities of MSCs is important for MSC-based regenerative medicine, such as craniofacial bone regeneration, and in new treatments for metabolic bone diseases, such as osteoporosis. In recent years, histone modification has been a growing topic in the field of MSC lineage specification, in which the Su(var)3–9, enhancer-of-zeste, trithorax (SET) domain-containing family and the Jumonji C (JmjC) domain-containing family represent the major histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs), respectively. In this review, we summarize the current understanding of the epigenetic mechanisms by which SET domain-containing KMTs and JmjC domain-containing KDMs balance the osteogenic and adipogenic differentiation of MSCs
The Histone Demethylase Activity of Rph1 is Not Essential for Its Role in the Transcriptional Response to Nutrient Signaling
- Author
- A Coluccio
- A Huber
- A Weiner
- AA Joshi
- AI Saeed
- AI Saeed
- AL Alejandro-Osorio
- B Li
- BD Fodor
- BD Strahl
- C Polytarchou
- C-Y Liang
- CB Brachmann
- CY Liang
- D Balciunas
- DA Hsia
- DW Kwon
- E Cameroni
- EA Schroeder
- EL Greer
- EL Humphrey
- F Crona
- F Huang
- GK Smyth
- Guo-Zhen Hu
- H Takahashi
- H Tamaru
- Hans Ronne
- I Pedruzzi
- Ida Olsson
- J Fang
- J He
- J Orzechowski Westholm
- J Oshiro
- J Roosen
- J Vandamme
- J Whetstine
- Jakub Orzechowski Westholm
- JO Nehlin
- JR Rohde
- L Gautier
- M Wei
- M Zofall
- M Öyen
- Mary Bryk
- Mattias Carlsson
- MC Keogh
- MJ Carrozza
- MT Lorbeck
- MT Pedersen
- N Bonneaud
- N Zhang
- N Zhang
- Niklas Nordberg
- PAC Cloos
- PD Siebert
- R Teperino
- R Tompa
- RC Gentleman
- RJ Klose
- RJ Klose
- RJ Klose
- S Chu
- S Tu
- SA Miller
- SK Kurdistani
- T Kim
- T Kouzarides
- T Xiao
- Y Benjamini
- Y Chang
- Y Shi
- Y Shi
- Y Tanaka
- Y Tsukada
- Y Yu
- YK Jang
- Z Chen
- Z Wu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Über die (aseptische) Harnstauungsniere
- Author
- A Adler-Ràcz von
- A Akerlund
- A Androulakakis
- A Androulakakis
- A Angelov
- A Babies
- A Babies
- A Barella
- A Batzenschlager
- A Berndorfer
- A Binz
- A Boone
- A Bouteau
- A Brenner
- A Christensen
- A Dufour
- A Döderlein
- A Feustel
- A Fritjofsson
- A Fritjofsson
- A Fränkel
- A Gabriele
- A Gaca
- A Gaca
- A Gaca
- A Gaca
- A Gentile
- A Giordano
- A Grunberg
- A Guetgemann
- A Guichard
- A Hagen
- A Hauge
- A Hauge
- A Homb
- A Hottinger
- A Illich
- A Israel
- A Kalo
- A Kohn
- A Kuntz
- A Lakos
- A Lardelli
- A Levievre
- A Lhez
- A Lichtenberg
- A Lichtenberg
- A Lisnell
- A Litwak
- A Ljungqvist
- A MacKellar
- A Martinez-Pineiro
- A Megevand
- A Napolitano
- A Paalanen
- A Paalanen
- A Paalanen
- A Pasqualino
- A Pena De la
- A Pena De la
- A Pena De la
- A Pichler
- A Pieper
- A Pieper
- A Pozzan
- A Randall
- A Rossier
- A Rothschild
- A Sadi
- A Sadi
- A Sadi
- A Saint-Aubert
- A Schabadasch
- A Schimatzek
- A Schwyzer
- A Sigel
- A Sigel
- A Sigel
- A Sigel
- A Surtshin
- A Szkodny
- A Theilhaber
- A Theilhaber
- A Thelen
- A Thelen
- A Thelen
- A Thiemann
- A Tormene
- A Trabucco
- A Tzank
- A Villanueva
- A Weicheisbaum
- A Wojewski
- A Wojewski
- A Wolf
- A Wolotzky
- A Wöller
- A Zinner
- A-A Kollwitz
- A-O Büchner
- AB Bhajekar
- AB Cecil
- AB Cecil
- AB Novikoff
- AB Stewart
- AC Abbott
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- AC Bratton
- AC Burton
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- AC Uson
- AC Uson
- AD Amar
- AD Dias
- AD Merrit
- AE Brule
- AE Brule
- AE Cohen
- AE Comarr
- AE Melnikoff
- AE Roche
- AH Baggenstoss
- AH Loufti
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- AH Smith
- AH Ulm
- AH Ulm
- AI Murphy
- AJ Bland
- AJ Botting
- AJ Fink
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- AJ McQueeney
- AJ Paquin
- AJ Paquin
- AJ Paquin
- AJ Spriggs
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- AM Hogben
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- E Haffner
- E Hagemann
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- E Hajos
- E Hanhart
- E Hienzsch
- E Hill
- E Holder
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- Evaluation of intubation ureterotomy with description of surgical technique
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- Experimental hydronephrosis without mechanical obstruction of the ureter
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- SE Englund
- SE Levy
- SG Jamsson
- SH Barron
- SI Björklund
- SJ Landau
- SJ Seidinger
- SK Kim
- SL Haber
- SL Roland
- SP Fedoroff
- SR Greenberg
- SR Kjellberg
- SR Weinberg
- SR Weinberg
- SR Weinberg
- SR Woodruff
- SS Ambrose
- SS Ambrose
- SS Ambrose
- SS Schmidt
- ST Knappenberger
- SW Litzenberger
- SW Stanbury
- T Bledsoe
- T Burchele
- T Burghele
- T Burkhart
- T Caniani
- T Covington
- T Ekström
- T Erdmann
- T Fahr
- T Hashmoto
- T Haskimoto
- T Hryntschak
- T Hryntschak
- T Hryntschak
- T Hryntschak
- T Hryntschak
- T James
- T Kusunoki
- T Kusunoki
- T Kusunoki
- T Minami
- T Omae’
- T Rovsing
- T Schultheiß
- T Shiratori
- T Strom
- T Tomoyoshi
- T Widen
- T Widen
- TB Wayman
- TD Moore
- TD Moore
- TE Gibson
- TE Gibson
- TE Gibson
- TF Yu
- TH Brodie
- TH Fracier
- TK Goodhand
- TL Chapman
- TL Horward
- TN Aas
- TR Fetter
- TW Engelmann
- U Heim
- U James
- V Becker
- V Blum
- V Blum
- V Borell
- V Brosch
- V Capek
- V Franciskovic
- V Frizzi
- V Gioustremes
- V Goldberg
- V Irving
- V Libro
- V Paces
- V Paces
- V Pliveric
- V Prat
- V Prät
- V Sitprija
- V Vintici
- VA Politano
- VA Politano
- VF Henderson
- VF Marshall
- VF Marshall
- VG Rodriguez-Acosta
- VJ Longo
- VJ O’Conor
- VJ O’Conor
- VJ O’Conor
- VJ O’Conor
- VL Robards
- VS Horwath
- VW Dix
- W Arnemann
- W Baumann
- W Berlin
- W Borgard
- W Brandt
- W Brinkmann
- W Brinkmann
- W Brosig
- W Brosig
- W Brosig
- W Brosig
- W Catel
- W Coppridge
- W Felix
- W Forssmann
- W Gregoir
- W Gregoir
- W Gregoir
- W Gregoir
- W Gütter
- W Heckenbach
- W Heintze
- W Henberger
- W Hinz
- W Hoffmann
- W Huth
- W Hüther
- W Kny
- W Kny
- W Kolmer
- W Kosenow
- W Lehmann
- W Lindemann
- W Lindemann
- W Lindemann
- W Lindemann
- W Lorbeck
- W Ludvik
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Marquardz
- W Modelski
- W Nonnenbruch
- W Pagel
- W Pagel
- W Pagel
- W Pagel
- W Pfeifer
- W Rattner
- W Samellas
- W Samellas
- W Schega
- W Schneider
- W Selberg
- W Singh
- W Sinner
- W Sinner
- W Sinner
- W Sleator
- W Staehler
- W Staehler
- W Suter
- W Teschendorf
- W Tlnnemeyer
- W Walters
- W Walters
- W Walters
- W Weibel
- W Weibel
- W Weiner
- W Weiner
- W Weisel
- W Wirbatz
- W Wüseke
- W Zaunbauer
- W Zimmer
- WA Griesbach
- WA Moonen
- WA Moonen
- WA Moonen
- WA Pepper
- WA Roll
- WA Roll
- WB Carpenter
- WB Schwartz
- WC Bailey
- WC Casey
- WC Quinby
- WC Quinby
- WD Jarman
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Lado
- WF Braasch
- WF Braasch
- WF Braasch
- WF Braasch
- WF Katzenstein
- WF Melick
- WF Melick
- WF Melick
- WFW Southwood
- WH Brinkmann
- WH Falor
- WH Howell
- WJ Baker
- WJ Engel
- WJ Forsythe
- WJ Forsythe
- WJ Israel
- WJ Rapp
- WJ Rapp
- WL Fitzgerald
- WM Bayliss
- WM Bochove van
- WM Davidson
- WM Drake
- WM Perelman
- WP Mulvaney
- WR McCune
- WR Schmalhorst
- WR Smart
- WS Kerr
- WS Kerr
- WS Kerr
- WS Mack
- WT Hunter
- WT Snodgrass
- WW Davey
- WW Milner
- WW Scott
- WW Summerville
- WW Woodward
- Y Fumio
- Y Kitani
- Y Lazebnik
- Y Satani
- Y Suzuki
- YG Miterev
- YJ Katz
- Z Kairis
- Z Kairis
- Z Kairis
- Z Kairis
- Z Nagy
- Z Piasecki
- ZHJ Vuurst Van Der
- Zur Behandlung postoperativer bzw. posttraumatischer Harnleiterfibrosen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1968
- Field of study