The Inverse of Exact Renormalization Group Flows as Statistical Inference

We build on the view of the Exact Renormalization Group (ERG) as an instantiation of Optimal Transport described by a functional convection–diffusion equation. We provide a new information-theoretic perspective for understanding the ERG through the intermediary of Bayesian Statistical Inference. This connection is facilitated by the Dynamical Bayesian Inference scheme, which encodes Bayesian inference in the form of a one-parameter family of probability distributions solving an integro-differential equation derived from Bayes’ law. In this note, we demonstrate how the Dynamical Bayesian Inference equation is, itself, equivalent to a diffusion equation, which we dub Bayesian Diffusion. By identifying the features that define Bayesian Diffusion and mapping them onto the features that define the ERG, we obtain a dictionary outlining how renormalization can be understood as the inverse of statistical inference

Using the Neuroadaptagen KB200z to Ameliorate Terrifying, Lucid Nightmares in RDS Patients: the Role of Enhanced, Brain-Reward, Functional Connectivity and Dopaminergic Homeostasis.

BACKGROUND: Lucid Dreams are a form of dream life, during which the dreamer may be aware that he/she is dreaming, can stop/re-start the dreams, depending on the pleasantness or unpleasant nature of the dream, and experiences the dream as if he/she were fully awake. Depending on their content, they may be pleasant, un-pleasant or terrifying, at least in the context of patients, who also exhibit characteristics of Reward Deficiency Syndrome (RDS) and Posttraumatic Stress Disorder (PTSD). CASE SERIES: We present eight clinical cases, with known substance abuse, childhood abuse and diagnosed PTSD/RDS. The administration of a putative dopamine agonist, KB200Z, was associated with the elimination of unpleasant and/or terrifying, lucid dreams in 87.5% of the cases presented, whereas one very heavy cocaine abuser showed a minimal response. These results required the continuous use of this nutraceutical. The lucid dreams themselves were distinguishable from typical, PTSD nightmares insofar as their content did not appear to reflect a symbolic rendition of an originally-experienced, historical trauma. Each of the cases was diagnosed with a form of RDS, i.e., ADHD, ADD, and/or Tourette's syndrome. They all also suffered from some form of Post-Traumatic-Stress-Disorder (PTSD) and other psychiatric diagnoses as well. CONCLUSION: The reduction or elimination of terrifying Lucid Dreams seemed to be dependent on KB220Z, whereby voluntary stopping of the agent results in reinstatement of the terrifying non-pleasant nature of the dreams. Following more required research on a much larger population we anticipate confirmation of these seemingly interesting observations. If these results in a small number of patients are indeed confirmed we may have found a frontline solution to a very perplexing and complicated symptom known as lucid dreams

Developing & Using Ontologies for the Semantic Web: An Inspirational and a Synthetic Approach to Ontological Engineering & Utilizing WordNet in Information Retrieval

Ontological engineering is explored via the inspirational approach of creating ontologies through one’s own imagination and the synthetic approach of developing ontologies through the synthesis of existing ones. The inspirational approach is implemented in two toolkits, one with minimal constructs and guidance and the other with constructs such a functional contexts and granularity. The synthetic approach is implemented in a toolkit that makes use of WordNet to generate semantically similar concepts across source ontologies, so as to support semi-automated merging. Lastly, an ontology-based information retrieval system is developed as a characteristic example of the use of ontologies in common applications

A Web tool for Geographic Information Systems

Geographic information system (GIS) users are growing in numbers everyday. The need for GIS systems is on an increase. This requires that information be made available on a large scale. This is a major problem that many GIS users are faced with. They require a tool that will allow them to supply the dataset and rapidly generate a resulting geographic web map that will be accessible by virtually anyone. Having been approached by the Marine & Coastal Management (MCM) services of Western Cape as well as the Cape Metropolitan Council (CMC) with this exact dilemma, we felt that their was a real need to develop a system that could help these GIS users. In essence, the system provides: • Useful and informative interactive mapping capabilities • A tool to dynamically generate these maps which can then be placed on the web for easy access The maps need to provide basic browsing capabilities, such as zooming, panning and layering various themes for display. Ideally it should provide added functionality, such as providing unique symbols for various features on the map. G-WIS, short for Geographic Web-tool Information System, is a tool that allows users to extract and publish these geographic web maps with relative ease. G-WIS is a stand-alone tool that is based on solid interface design methods. It allows a user to define a dataset that can be used to generate a web page, which embeds a Java Applet that reads the data and maps this in the form of a geographical map. The key findings that were found after testing the G-WIS application are: 1. Supports long term and efficient management of data. 2. Promotes rapid generation of web maps. 3. Implements an “attractive and easy to use” interface. 4. Further development or improvements can be due to the use of XML. 5. Has the ability to solve real world problems. 6. Is cost effective. Generating web maps with G-WIS is easy, fast and cost effective. After testing the interactive maps, it was found that: 1. The maps were easy to use 2. It provided the basic needs for web mapping. 3. It was informative and useful Implementing the maps using GeoTools caused a huge setback in the progress of the project, since GeoTools is poorly documented and only a few experts exist. Advanced functionality was thus not provided. Even though the maps only provided the basic functionality, it met the needs for functional interactive web map browsing

Developing a Basis for Knowledge Management: A Bayesian Network Approach

Knowledge Management (KM) is an evolving field that attempts to maximise and sustain the competitive advantage of a company through leveraging its knowledge resources. KM practises are often built on a foundation of knowledge transfer and knowledge sharing. Recently there has been an increase on the reliance of automated tools to perform these functions. Typical components of these tools include: querying large datasets, user profiling, user interfaces and recommender systems. Traditionally, these components have been implemented using different technologies. This paper describes an approach to building these components using a flexible architecture based on Bayesian Network technology. Finally the paper considers some of the advantages to adopting the latter approach

M2-M5 blackfold funnels

We analyze the basic M2-M5 intersection in the supergravity regime using the blackfold approach. This approach allows us to recover the 1/4-BPS self-dual string soliton solution of Howe, Lambert and West as a three-funnel solution of an effective fivebrane worldvolume theory in a new regime, the regime of a large number of M2 and M5 branes. In addition, it allows us to discuss finite temperature effects for non-extremal self-dual string soliton solutions and wormhole solutions interpolating between stacks of M5 and anti-M5 branes. The purpose of this paper is to exhibit these solutions and their basic properties.Comment: 19 pages, 5 figures, harvmac; typo corrected in equation (3.19

Systematic reviews of complementary therapies - an annotated bibliography. Part 1: Acupuncture

Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with acupuncture. Potentially relevant reviews were searched through the register of the Cochrane Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and books. To be included articles had to review prospective clinical trials of acupuncture; had to describe review methods explicitly; had to be published; and had to focus on treatment effects. Information on conditions, interventions, methods, results and conclusions was extracted using a pretested form and summarized descriptively. Results From a total of 48 potentially relevant reviews preselected in a screeening process 39 met the inclusion criteria. 22 were on various pain syndromes or rheumatic diseases. Other topics addressed by more than one review were addiction, nausea, asthma and tinnitus. Almost unanimously the reviews state that acupuncture trials include too few patients. Often included trials are heterogeneous regarding patients, interventions and outcome measures, are considered to have insufficient quality and contradictory results. Convincing evidence is available only for postoperative nausea, for which acupuncture appears to be of benefit, and smoking cessation, where acupuncture is no more effective than sham acupuncture. Conclusions A large number of systematic reviews on acupuncture exists. What is most obvious from these reviews is the need for (the funding of) well-designed, larger clinical trials

Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score

©2008 Pandit and Skolnick; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article is available from: http://www.biomedcentral.com/1471-2105/9/531doi:10.1186/1471-2105-9-531Background: Protein tertiary structure comparisons are employed in various fields of contemporary structural biology. Most structure comparison methods involve generation of an initial seed alignment, which is extended and/or refined to provide the best structural superposition between a pair of protein structures as assessed by a structure comparison metric. One such metric, the TM-score, was recently introduced to provide a combined structure quality measure of the coordinate root mean square deviation between a pair of structures and coverage. Using the TM-score, the TM-align structure alignment algorithm was developed that was often found to have better accuracy and coverage than the most commonly used structural alignment programs; however, there were a number of situations when this was not true. Results: To further improve structure alignment quality, the Fr-TM-align algorithm has been developed where aligned fragment pairs are used to generate the initial seed alignments that are then refined using dynamic programming to maximize the TM-score. For the assessment of the structural alignment quality from Fr-TM-align in comparison to other programs such as CE and TMalign, we examined various alignment quality assessment scores such as PSI and TM-score. The assessment showed that the structural alignment quality from Fr-TM-align is better in comparison to both CE and TM-align. On average, the structural alignments generated using Fr-TM-align have a higher TM-score (~9%) and coverage (~7%) in comparison to those generated by TM-align. Fr- TM-align uses an exhaustive procedure to generate initial seed alignments. Hence, the algorithm is computationally more expensive than TM-align. Conclusion: Fr-TM-align, a new algorithm that employs fragment alignment and assembly provides better structural alignments in comparison to TM-align. The source code and executables of Fr- TM-align are freely downloadable at: http://cssb.biology.gatech.edu/skolnick/files/FrTMalign/

Observation of anomalous decoherence effect in a quantum bath at room temperature

Decoherence of quantum objects is critical to modern quantum sciences and technologies. It is generally believed that stronger noises cause faster decoherence. Strikingly, recent theoretical research discovers the opposite case for spins in quantum baths. Here we report experimental observation of the anomalous decoherence effect for the electron spin-1 of a nitrogen-vacancy centre in high-purity diamond at room temperature. We demonstrate that under dynamical decoupling, the double-transition can have longer coherence time than the single-transition, even though the former couples to the nuclear spin bath as twice strongly as the latter does. The excellent agreement between the experimental and the theoretical results confirms the controllability of the weakly coupled nuclear spins in the bath, which is useful in quantum information processing and quantum metrology.Comment: 22 pages, related paper at http://arxiv.org/abs/1102.557