Aesthetic Response

'Aesthetic response' is one of a constellation of related terms and concepts (e.g., aesthetic experience. aesthetic judgement. aesthetic choice, affective response, musical appreciation, musical preference, musical taste) that have been employed in music education research, theory. and practice when attempting to describe and/or define the nature of music knowing, experience, and judgement. As such the concept of aesthetic response is deeply problematic, an 'essentially contested concept' (Gallie, 1964; Bar rett, 2002), To separate the terms, the 'aesthetic' stems from a philosophical tradition establish ed in th e eigh te ent h century, which drew on the legacy of the Ancient Greeks in an attempt to determine the nature. meaning and value of the arts and sensory experience to human existence. The latter term 'response' implies the end-point of some form of interaction; one that could be the result of precipitate stimulation, behaviourist training. or, considered reflection. While originally located in the realm of philosophy, when wedded to 'response', and placed in the context of music education, 'aesthetic response' has also been the object of study within psychology and sociology

Geometry of Information Integration

Information geometry is used to quantify the amount of information integration within multiple terminals of a causal dynamical system. Integrated information quantifies how much information is lost when a system is split into parts and information transmission between the parts is removed. Multiple measures have been proposed as a measure of integrated information. Here, we analyze four of the previously proposed measures and elucidate their relations from a viewpoint of information geometry. Two of them use dually flat manifolds and the other two use curved manifolds to define a split model. We show that there are hierarchical structures among the measures. We provide explicit expressions of these measures

Farmer perceptions and responses to soil degradation in Swaziland

Soil degradation is globally concerning due to its adverse effects on the environment and agricultural production. Much of Swaziland is at risk from degradation. This paper assesses farmer perceptions and responses to soil degradation in 2002 and 2014, focusing on two land uses that underpin rural livelihoods: arable land and rangeland areas. It uses repeat household surveys and semi-structured interviews, in two case study chiefdoms in the country’s middleveld (KaBhudla and Engcayini) in the first longitudinal study of its kind. We find that observations of land degradation are perceived mainly through changes in land productivity, with chemical degradation occurring predominantly on arable land and physical degradation and erosion mainly in rangeland areas. Changes in rainfall are particularly important in determining responses. While perceptions of the causes and impacts of degradation largely concur with the scientific literature, responses were constrained by poor land availability, shorter and more unpredictable cropping seasons because of changing rains and low awareness, access to or knowledge of agricultural inputs. We suggest that sustainable arable land management can be enhanced through improved access to alternative sources of water, use of management practices that retain soil and moisture and greater access to agricultural inputs and capacity building to ensure their appropriate use. We suggest collaborative management for settlement planning that integrates soil conservation and livestock management strategies such as controlled stocking levels and rotational grazing could improve land quality in rangeland areas. Together, these approaches can help land users to better manage change

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation

Deciphering regulatory events that drive malignant transformation represents a major challenge for systems biology. Here we analyzed genome-wide transcription profiling of an in-vitro transformation process. We focused on a cluster of genes whose expression levels increased as a function of p53 and p16INK4A tumor suppressors inactivation. This cluster predominantly consists of cell cycle genes and constitutes a signature of a diversity of cancers. By linking expression profiles of the genes in the cluster with the dynamic behavior of p53 and p16INK4A, we identified a promoter architecture that integrates signals from the two tumor suppressive channels and that maps their activity onto distinct levels of expression of the cell cycle genes, which in turn, correspond to different cellular proliferation rates. Taking components of the mitotic spindle as an example, we experimentally verified our predictions that p53-mediated transcriptional repression of several of these novel targets is dependent on the activities of p21, NFY and E2F. Our study demonstrates how a well-controlled transformation process allows linking between gene expression, promoter architecture and activity of upstream signaling molecules.Comment: To appear in Molecular Systems Biolog

Presymptomatic risk assessment for chronic non-communicable diseases

The prevalence of common chronic non-communicable diseases (CNCDs) far overshadows the prevalence of both monogenic and infectious diseases combined. All CNCDs, also called complex genetic diseases, have a heritable genetic component that can be used for pre-symptomatic risk assessment. Common single nucleotide polymorphisms (SNPs) that tag risk haplotypes across the genome currently account for a non-trivial portion of the germ-line genetic risk and we will likely continue to identify the remaining missing heritability in the form of rare variants, copy number variants and epigenetic modifications. Here, we describe a novel measure for calculating the lifetime risk of a disease, called the genetic composite index (GCI), and demonstrate its predictive value as a clinical classifier. The GCI only considers summary statistics of the effects of genetic variation and hence does not require the results of large-scale studies simultaneously assessing multiple risk factors. Combining GCI scores with environmental risk information provides an additional tool for clinical decision-making. The GCI can be populated with heritable risk information of any type, and thus represents a framework for CNCD pre-symptomatic risk assessment that can be populated as additional risk information is identified through next-generation technologies.Comment: Plos ONE paper. Previous version was withdrawn to be updated by the journal's pdf versio

Understanding Sensory Processing Disorder in a Special Education Classroom: A Reflective Inquiry

Abstract This essay is comprised with reflective experiences with sensory processing disorder (SPD) in the classroom as a new teacher. Challenges that were experienced when navigating SPD and its characteristics. Initially unaware of SPD and its nuanced characteristics, significant hurdles were shared. SPD can be mishandled and mislabeled and can lead to learning barriers and emotional triggers. I describe ways to engaged in appropriate interventions and accommodations that work when applied correctly, timely, and specific. From this experience, I was able to create my own sensory solution that serves the needs of all my sensational learners in the classroom. A shared insight garnered from trail and error leading to practical practices and solutions. I aim to contribute to a broader discussion on inclusive education and advocate for informed approaches to supporting individuals with SPD in educational settings. Keywords: Sensory processing disorder (SPD), Ayres sensory integration (ASI), sensory behaviors, early childhood

Music early learning programs: Enduring outcomes for children and their families

Music early learning programs (MELPs) that provide music services to parents and carers of children aged birth through 8 years are proliferating. Parents make significant financial and social investments in MELPs, yet little is known of their motivations and aspirations nor of the enduring outcomes of participation. This article reports the findings of an interview study with 10 parents, 1 grandparent, and 8 child former participants in a MELP program in regional Australia that investigated perceptions of MELP participation. Findings indicate that parents come from a range of musical backgrounds. Reasons and aspirations for MELP enrolment encompass developing both parents’ and children’s musical skills, providing social benefits for parent and child, exposure to musical experience, value-adding to their child’s education and expanding the family social circle. Enduring outcomes include developed music knowledge and skills, future investments, physical and emotional development, and new patterns of learning that are potentially transferable. Findings suggest that children arrive at formal schooling with a rich repertoire of music, a capacity to engage in embodied musical experience, and a set of expectations concerning their participation in music. Such knowledge holds implications for the ways in which music learning might be structured within the early childhood classroom

Molecular and immunological analysis of Avipoxvirus in avian samples and comparison of local potential mosquito vector populations

An outbreak of Avipoxvirus occurred on a small farm in Gorham, ME in spring of 2022. This led to an investigation of the molecular and immunological properties of the virus using polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISAs) to assess viral presence and antibody presence in domestic and wild turkeys and chickens. Viral presence was found in three visually pox-lesioned birds, and not found in two visually pox-lesioned birds. Viral presence was found in three visually healthy birds and not found in two visually healthy birds. Viral presence was not found in any pooled samples of mosquitoes (n=429 Culex pipiens and Culex restuans). Birds infected in spring of 2022, recovered, and harvested in fall 2023 were utilized as positive controls in ELISAs. All domestic and wild turkey samples were positive for viral presence regardless of pox-lesion presence

Coherent spinor dynamics in a spin-1 Bose condensate

Collisions in a thermal gas are perceived as random or incoherent as a consequence of the large numbers of initial and final quantum states accessible to the system. In a quantum gas, e.g. a Bose-Einstein condensate or a degenerate Fermi gas, the phase space accessible to low energy collisions is so restricted that collisions be-come coherent and reversible. Here, we report the observation of coherent spin-changing collisions in a gas of spin-1 bosons. Starting with condensates occupying two spin states, a condensate in the third spin state is coherently and reversibly created by atomic collisions. The observed dynamics are analogous to Josephson oscillations in weakly connected superconductors and represent a type of matter-wave four-wave mixing. The spin-dependent scattering length is determined from these oscillations to be -1.45(18) Bohr. Finally, we demonstrate coherent control of the evolution of the system by applying differential phase shifts to the spin states using magnetic fields.Comment: 19 pages, 3 figure

Neuroactive steroids in depression and anxiety disorders: Clinical studies

Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor. During major depression, there is a disequilibrium of 3 alpha-reduced neuroactive steroids, which is corrected by clinically effective pharmacological treatment. To investigate whether these alterations are a general principle of successful antidepressant treatment, we studied the impact of nonpharmacological treatment options on neuroactive steroid concentrations during major depression. Neither partial sleep deprivation, transcranial magnetic stimulation, nor electroconvulsive therapy affected neuroactive steroid levels irrespectively of the response to these treatments. These studies suggest that the changes in neuroactive steroid concentrations observed after antidepressant pharmacotherapy more likely reflect distinct pharmacological properties of antidepressants rather than the clinical response. In patients with panic disorder, changes in neuroactive steroid composition have been observed opposite to those seen in depression. However, during experimentally induced panic induction either with cholecystokinine-tetrapeptide or sodium lactate, there was a pronounced decline in the concentrations of 3 alpha-reduced neuroactive steroids in patients with panic disorder, which might result in a decreased GABAergic tone. In contrast, no changes in neuroactive steroid concentrations could be observed in healthy controls with the exception of 3 alpha,5 alpha-tetrahydrodeoxycorticosterone. The modulation of GABA(A) receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds. Copyright (c) 2006 S. Karger AG, Basel