Impacts of three pesticides on arthropod biodiversity in brinjal agro-ecosystem

A field study was conducted to find out the impact of three selected pesticides on arthropod biodiversity in brinjal agro-ecosystem during 2011-2012 at Bangabandhu Sheikh Mujibur Rahman Agricultural University (BSMRAU). Twenty-six arthropod species were observed through visual searching method out of which 18 were insect pest species (from 14 families under 8 orders) and 8 were natural enemies (from 8 families under 6 families). Twenty one species of surface dwelling arthropods were caught in pitfall traps method, 12 of them were insect pest species (from 11 families under 8 orders) and 9 were natural enemies (from 9 families under 5 orders). Formicidae was the most abundant family among them. Bacillus thuringiensis (Bt) and Tracer 45SC (Spinosad) were less harmful to arthropod pest species as well as natural enemies in the brinjal agro-ecosystem. Proclaim 5SG reduced the overall abundance of arthropod species. Bacillus thuringiensis (Bt) and Tracer 45SC were relatively safe for natural enemies and therefore would be fit well into integrated pest management (IPM) against BSFB of brinjal crop.Int. J. Agril. Res. Innov. & Tech. 8 (1): 55-61, June, 201

Modeling the optimal mitigation of potential impact of climate change on coastal ecosystems.

Global warming is adversely affecting the earth's climate system due to rapid emissions of greenhouse gases (GHGs). Consequently, the world's coastal ecosystems are rapidly approaching a dangerous situation. In this study, we formulate a mathematical model to assess the impact of rapid emissions of GHGs on climate change and coastal ecosystems. Furthermore, we develop a mitigation method involving two control strategies: coastal greenbelt and desulfurization. Here, greenbelt is considered in coastal areas to reduce the concentrations of GHGs by absorbing the environmental carbon dioxide (CO2), whereas desulfurization is considered in factories and industries to reduce GHG emissions by controlling the release of harmful sulfur compounds. The model and how it can control the situation are analytically verified. Numerical results of this study are confirmed by comparison with other studies that examine different scenarios. Results show that both control strategies can mitigate GHG concentrations, curtail global warming and to some extent manage climate change. The results further reveal that both control strategies are more effective than one control method. Overall, the results suggest that the concentrations of GHGs and the effects of climate change can be controlled by adopting sufficient coastal greenbelt and desulfurization techniques in various industries

Weight-related status and associated predictors with psychological well-being among first-year university students in Bangladesh: a pilot study

University students (especially first-years) not only have to cope with their academic curriculum but also issues such as being away from the home environment and living independently for the first time. Those who do not adapt quickly to these new conditions are likely to be susceptible to physical and psychological vulnerabilities. The present study surveyed first-year Bangladeshi undergraduate students to investigate their weight status (i.e., the prevalence of being normal weight, underweight, overweight, and obese) and the prevalence of depression and associated risk factors. A cross-sectional survey was conducted among 404 first-year university students (aged 18–23 years) residing at a Bangladeshi university. The participants completed a survey examining socio-demographic and behavioral variables, alongside the WHO-5 Well-Being Index. Binary logistic regression was performed to determine significant associations between the variables under examination. Prevalence rates of being normal weight, underweight, overweight, and obese were 66.8%, 20.3%, 9.7%, and 3.2% respectively. Associated predictors of weight-related problems were being female and lack of physical exercise. The prevalence rate of depression was 68.1%. There were no significant gender differences and associated predictors of depression were lack of physical exercise, unsatisfactory sleep quality, excessive internet use, and excessive reading hours. Being underweight, overweight, or being obese alongside the prevalence of depression among first-year university students were high. Findings indicate that first-year university students are a vulnerable group for some physical and psychological problems. Findings recommend the need for intervention programs, alongside adequate and appropriate supportive services for first-year Bangladeshi university students

Suitability of Chlorella ellipsoidea as food for production of the rotifer Brachionus calyciflorus

Rotifers are valuable live food for larval fish and crustacean in aquaculture. In the present study, we conducted an experiment to evaluate the suitability of Chlorella ellipsoidea as food for production of the rotifer, Brachionus calyciflorus. The experiment was carried out in three treatments using dried powder Chlorella ellipsoidea (T1), fresh live Chlorella ellipsoidea (T2) and Bakers yeast (T3) as food with three replications. For supplying food to rotifers, C. ellipsoidea was cultured sufficiently in different inexpensive culture media before rotifer culture and it was continued up to the end of the rotifer culture experiment. The ranges of environmental factors analyzed were suitable for both C. ellipsoidea and rotifers culture during the experimental period. Maximum cell densities of C. ellipsoidea were recorded in inexpensive pulse bran extract medium during the culture period. The mean population densities (means ± SEM) of B. calyciflorus were significantly (p<0.01) highest in T2 (28.6 ± 4.64 (x103) individuals L-1) compared to T1 (11.6 ± 1.24 (x103) individuals L-1) and T3 (11.4 ± 1.82 (x103) individuals L-1). The findings of present study revealed that fresh cultured C. ellipsoidea was the best food for production of the rotifer, B. calyciflorus. DOI: http://dx.doi.org/10.3329/ijarit.v3i2.17843 Int. J. Agril. Res. Innov. & Tech. 3 (2): 41-48, December, 201

Differential Ligand Binding to a Human Cytomegalovirus Chemokine Receptor Determines Cell Type–Specific Motility

While most chemokine receptors fail to cross the chemokine class boundary with respect to the ligands that they bind, the human cytomegalovirus (HCMV)-encoded chemokine receptor US28 binds multiple CC-chemokines and the CX3C-chemokine Fractalkine. US28 binding to CC-chemokines is both necessary and sufficient to induce vascular smooth muscle cell (SMC) migration in response to HCMV infection. However, the function of Fractalkine binding to US28 is unknown. In this report, we demonstrate that Fractalkine binding to US28 not only induces migration of macrophages but also acts to inhibit RANTES-mediated SMC migration. Similarly, RANTES inhibits Fractalkine-mediated US28 migration in macrophages. While US28 binding of both RANTES and Fractalkine activate FAK and ERK-1/2, RANTES signals through Gα12 and Fractalkine through Gαq. These findings represent the first example of differential chemotactic signaling via a multiple chemokine family binding receptor that results in migration of two different cell types. Additionally, the demonstration that US28-mediated chemotaxis is both ligand-specific and cell type–specific has important implications in the role of US28 in HCMV pathogenesis

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

Although evidence is accumulating that diabetes mellitus is an important risk factor for sporadic Alzheimer's disease (AD), the mechanisms by which defects in insulin signaling may lead to the acceleration of AD progression remain unclear. In this study, we applied streptozotocin (STZ) to induce experimental diabetes in AD transgenic mice (5XFAD model) and investigated how insulin deficiency affects the β-amyloidogenic processing of amyloid precursor protein (APP). Two and half months after 5XFAD mice were treated with STZ (90 mg/kg, i.p., once daily for two consecutive days), they showed significant reductions in brain insulin levels without changes in insulin receptor expression. Concentrations of cerebral amyloid-β peptides (Aβ40 and Aβ42) were significantly increased in STZ-treated 5XFAD mice as compared with vehicle-treated 5XFAD controls. Importantly, STZ-induced insulin deficiency upregulated levels of both β-site APP cleaving enzyme 1 (BACE1) and full-length APP in 5XFAD mouse brains, which was accompanied by dramatic elevations in the β-cleaved C-terminal fragment (C99). Interestingly, BACE1 mRNA levels were not affected, whereas phosphorylation of the translation initiation factor eIF2α, a mechanism proposed to mediate the post-transcriptional upregulation of BACE1, was significantly elevated in STZ-treated 5XFAD mice. Meanwhile, levels of GGA3, an adapter protein responsible for sorting BACE1 to lysosomal degradation, are indistinguishable between STZ- and vehicle-treated 5XFAD mice. Moreover, STZ treatments did not affect levels of Aβ-degrading enzymes such as neprilysin and insulin-degrading enzyme (IDE) in 5XFAD brains. Taken together, our findings provide a mechanistic foundation for a link between diabetes and AD by demonstrating that insulin deficiency may change APP processing to favor β-amyloidogenesis via the translational upregulation of BACE1 in combination with elevations in its substrate, APP

The effect of community groups and mobile phone messages on the prevention and control of diabetes in rural Bangladesh : study protocol for a three-arm cluster randomised controlled trial

BACKGROUND: Increasing rates of type 2 diabetes mellitus place a substantial burden on health care services, communities, families and individuals living with the disease or at risk of developing it. Estimates of the combined prevalence of intermediate hyperglycaemia and diabetes in Bangladesh vary, and can be as high as 30% of the adult population. Despite such high prevalence, awareness and control of diabetes and its risk factors are limited. Prevention and control of diabetes and its complications demand increased awareness and action of individuals and communities, with positive influences on behaviours and lifestyle choices. In this study, we will test the effect of two different interventions on diabetes occurrence and its risk factors in rural Bangladesh. METHODS/DESIGN: A three-arm cluster randomised controlled trial of mobile health (mHealth) and participatory community group interventions will be conducted in four rural upazillas in Faridpur District, Bangladesh. Ninety-six clusters (villages) will be randomised to receive either the mHealth intervention or the participatory community group intervention, or be assigned to the control arm. In the mHealth arm, enrolled individuals will receive twice-weekly voice messages sent to their mobile phone about prevention and control of diabetes. In the participatory community group arm, facilitators will initiate a series of monthly group meetings for men and women, progressing through a Participatory Learning and Action cycle whereby group members and communities identify, prioritise and tackle problems associated with diabetes and the risk of developing diabetes. Both interventions will run for 18 months. The primary outcomes of the combined prevalence of intermediate hyperglycaemia and diabetes and the cumulative 2-year incidence of diabetes among individuals identified as having intermediate hyperglycaemia at baseline will be evaluated through baseline and endline sample surveys of permanent residents aged 30 years or older in each of the study clusters. Data on blood glucose level, blood pressure, body mass index and hip-to-waist ratio will be gathered through physical measurements by trained fieldworkers. Demographic and socioeconomic data, as well as data on knowledge of diabetes, chronic disease risk factor prevalence and quality of life, will be gathered through interviews with sampled respondents. DISCUSSION: This study will increase our understanding of diabetes and other non-communicable disease burdens and risk factors in rural Bangladesh. By documenting and evaluating the delivery, impact and cost-effectiveness of participatory community groups and mobile phone voice messaging, study findings will provide evidence on how population-level strategies of community mobilisation and mHealth can be implemented to prevent and control noncommunicable diseases and risk factors in this population. TRIAL REGISTRATION: ISRCTN41083256 . Registered on 30 Mar 2016 (Retrospectively Registered). TRIAL ACRONYM: D-Magic: Diabetes Mellitus - Action through Groups or mobile Information for better Control

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer